Twinfilin-2a is dispensable for mouse development.

Autor: Elisa M Nevalainen, Attila Braun, Maria K Vartiainen, Martina Serlachius, Leif C Andersson, Markus Moser, Pekka Lappalainen

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e22894 (2011)

Twinfilins are evolutionarily conserved regulators of cytoskeletal dynamics. They inhibit actin polymerization by binding both actin monomers and filament barbed ends. Inactivation of the single twinfilin gene from budding yeast and fruit fly results

Externí odkaz: https://doaj.org/article/8b7f49b563d64fc0a167c068b669cb85

Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene

Autor: Elisa M. Nevalainen, Osmo Hakosalo, Janelle M. Belanger, Ranno Viitmaa, Lotta L. E. Koskinen, Meharji Arumilli, Tarja S. Jokinen, Anita M. Oberbauer, Päivi Jokinen, Eija H. Seppälä, Hannes Lohi

Publikováno v: BMC genomics, vol 16, iss 1
BMC Genomics
Koskinen, LLE; Seppälä, EH; Belanger, JM; Arumilli, M; Hakosalo, O; Jokinen, P; et al.(2015). Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene. BMC Genomics, 16(1). doi: 10.1186/s12864-015-1651-9. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5zw98611

Background Idiopathic epilepsy is a common neurological disease in human and domestic dogs but relatively few risk genes have been identified to date. The seizure characteristics, including focal and generalised seizures, are similar between the two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5a2d1295fc25512ddee309b34910b3
https://escholarship.org/uc/item/5zw98611

Novel origins of copy number variation in the dog genome

Autor: Christophe Hitte, Michael C. Zody, Michele Perloski, Jonas Berglund, Matthew T. Webster, Hannes Lohi, Ted Sharpe, Elisa M. Nevalainen, Anna-Maja Molin, Catherine André, Kerstin Lindblad-Toh

Publikováno v: Genome Biology
Genome Biology, BioMed Central, 2012, 13 (8), pp.R73. ⟨10.1186/gb-2012-13-8-r73⟩
Genome Biology, 2012, 13 (8), pp.R73. ⟨10.1186/gb-2012-13-8-r73⟩
Genome Biology; Vol 13

BACKGROUND: Copy number variants (CNVs) account for substantial variation between genomes and are a major source of normal and pathogenic phenotypic differences. The dog is an ideal model to investigate mutational mechanisms that generate CNVs as its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6940c9d90481540c54df38d332886a4e
https://www.hal.inserm.fr/inserm-00728391

MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear

Autor: Haydn M. Prosser, Agnieszka K. Rzadzinska, Elisa M. Nevalainen, Pekka Lappalainen, Karen P. Steel

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e7097 (2009)
PLoS ONE

In vertebrates hearing is dependent upon the microvilli-like mechanosensory stereocilia and their length gradation. The staircase-like organization of the stereocilia bundle is dynamically maintained by variable actin turnover rates. Two unconvention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc573411c50cde2f5925ee9bf972773f
http://europepmc.org/articles/PMC2743196?pdf=render

Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage

Autor: Markus Moser, Pekka Lappalainen, Aneta Skwarek-Maruszewska, Elisa M. Nevalainen, Attila Braun

Publikováno v: Biochemical Journal
Biochemical Journal, Portland Press, 2008, 417 (2), pp.593-600. ⟨10.1042/BJ20080608⟩

International audience; Twinfilin is an evolutionarily conserved regulator of actin dynamics composed of two actin-depolymerizing factor homology (ADF-H) domains. Twinfilin binds actin monomers and heterodimeric capping protein with high affinity. Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb609d75f60c1d0140c6a20a3545b2f
https://pubmed.ncbi.nlm.nih.gov/18837697