Optimization of the classical oral cancerization protocol in hamster to study oral cancer therapy

Autor: Emiliano C. C. Pozzi, Juan S. Guidobono, Verónica A. Trivillin, David W. Nigg, Iara S Santa Cruz, P. Curotto, Andrea Monti Hughes, Elisa M. Heber, S. Thorp, Marcela A. Garabalino, Maria E. Itoiz, Amanda E. Schwint

Publikováno v: Oral diseasesREFERENCES.

Objective(s) The hamster carcinogenesis model recapitulates oral oncogenesis. Dimethylbenz[a]anthracene (DMBA) cancerization induces early severe mucositis, affecting animal's welfare and causing tissue loss and pouch shortening. "Short" pouches cann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29730501f44c7a72b7ed162d038ea78b
https://pubmed.ncbi.nlm.nih.gov/32297432

Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies

Autor: Elisa M. Heber, Andrea Monti Hughes, Marcela A. Garabalino, Amanda E. Schwint, Verónica A. Trivillin, Emiliano C. C. Pozzi

Publikováno v: Boron-Based Compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67126cfa86759a7a559857365e8aab65
https://doi.org/10.1002/9781119275602.ch3.6

Boron neutron capture therapy (BNCT) translational studies in the hamster cheek pouch model of oral cancer at the new 'B2' configuration of the RA-6 nuclear reactor

Autor: David W. Nigg, Emiliano C. C. Pozzi, Elisa M. Heber, Amanda E. Schwint, Andrea Monti Hughes, Vanina Araceli Medina, Diego José Martinel Lamas, Juan Longhino, Verónica A. Trivillin, Maria E. Itoiz, Marcela A. Garabalino, Esteban Boggio, Romina F. Aromando

Publikováno v: Radiat Environ Biophys Vol.56, No.4, 2017
Repositorio Institucional (UCA)
Pontificia Universidad Católica Argentina
instacron:UCA

Boron neutron capture therapy (BNCT) is based on selective accumulation of B-10 carriers in tumor followed by neutron irradiation. We demonstrated, in 2001, the therapeutic effect of BNCT mediated by BPA (boronophenylalanine) in the hamster cheek pou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9246de1554697784a3802f16be402154
https://pubmed.ncbi.nlm.nih.gov/28871389

Assessing advantages of sequential boron neutron capture therapy (BNCT) in an oral cancer model with normalized blood vessels

Autor: Silva Bortolussi, Andrea Monti Hughes, S. Thorp, Maria E. Itoiz, Marcela A. Garabalino, Agustina Portu, Elisa M. Heber, Verónica A. Trivillin, Ana J. Molinari, Amanda E. Schwint, Romina F. Aromando, Saverio Altieri, Emiliano C. C. Pozzi, Gisela Saint Martin

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

BACKGROUND: We previously demonstrated the therapeutic success of sequential boron neutron capture therapy (Seq-BNCT) in the hamster cheek pouch oral cancer model. It consists of BPA-BNCT followed by GB-10-BNCT 24 or 48 hours later. Additionally, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2129c51e281a8d974c33685af2df9e
https://doi.org/10.3109/0284186x.2014.925140

Biodistribution of sodium borocaptate (BSH) for boron neutron capture therapy (BNCT) in an oral cancer model

Autor: Verónica A. Trivillin, Romina F. Aromando, Andrea Monti Hughes, David W. Nigg, S. Nievas, Emiliano C. C. Pozzi, Sara J. González, Amanda E. Schwint, Ana J. Molinari, Elisa M. Heber, Marcela A. Garabalino, William F. Bauer, Maria E. Itoiz

Publikováno v: Radiation and Environmental Biophysics. 52:351-361

Boron neutron capture therapy (BNCT) is based on selective accumulation of 10B carriers in tumor followed by neutron irradiation. We previously proved the therapeutic success of BNCT mediated by the boron compounds boronophenylalanine and sodium deca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0951247e362c7e654dd5cbb0c2398bf
https://doi.org/10.1007/s00411-013-0467-8