Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Elisa M. Crombie"'
Publikováno v:
Royal Society Open Science, Vol 11, Iss 9 (2024)
The transcriptional machinery is essential for gene expression and regulation; dysregulation of transcription can result in a range of pathologies, including neurodegeneration, cancer, developmental disorders and cardiovascular disease. A key compone
Externí odkaz:
https://doaj.org/article/73a308574cb149d0b9df95ea024d723e
Autor:
Elisa M. Crombie, Andrea J. Korecki, Karen Cleverley, Bethany A. Adair, Thomas J. Cunningham, Weaverly Colleen Lee, Tess C. Lengyell, Cheryl Maduro, Victor Mo, Liam M. Slade, Ines Zouhair, Elizabeth M. C. Fisher, Elizabeth M. Simpson
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/9121673d743d4e96a21019e14ea29d93
Autor:
Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 1, Pp 198-213 (2023)
Abstract Background Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal
Externí odkaz:
https://doaj.org/article/4d1f09455d51452bad1e1f064452da26
Autor:
Seok-Ting J. Ang, Elisa M. Crombie, Han Dong, Kuan-Ting Tan, Adriel Hernando, Dejie Yu, Stuart Adamson, Seonyoung Kim, Dominic J. Withers, Hua Huang, Shih-Yin Tsai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The group of Shih-Yin Tsai observed age-associated neuromuscular junction structural instability in male but not female mice which is driven by dysregulation of mTOR complex 1 activity. Genetic activation of the downstream phosphorylation target 4EBP
Externí odkaz:
https://doaj.org/article/eda0b3d0d84b4f68a117977871132f65
Autor:
Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Publikováno v:
Crombie, E M, Kim, S, Adamson, S, Dong, H, Lu, T C, Wu, Y, Wu, Y, Levy, Y, Stimple, N, Lam, W M R, Hey, H W D, Withers, D J, Hsu, A L, Bay, B H, Ochala, J & Tsai, S Y 2023, ' Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity ', Journal of Cachexia, Sarcopenia and Muscle, vol. 14, pp. 198–213 . https://doi.org/10.1002/jcsm.13121
Background: Chronic mTORC1 activation in skeletal muscle is linked with age-associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal muscle acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06101ab26f9a9e231a7eb21cd4c471a2
https://doi.org/10.1002/jcsm.13121
https://doi.org/10.1002/jcsm.13121