Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elisa Leung"'
Autor:
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the relat
Externí odkaz:
https://doaj.org/article/d148e9686840428483903862c1681076
Autor:
Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa-Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, Marta Haniszewski, Noha Miah, Sadhna Phanse, Zoran Minic, Sukyeong Lee, Julio Diaz Caballero, Mohan Babu, Francis T. F. Tsai, Tomohide Saio, Walid A. Houry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
ClpXP is the main ATP-dependent proteolytic complex in bacteria, is essential for maintaining cellular protein homeostasis and is also critical for bacterial pathogenesis. Here, the authors establish a functional link between ClpXP and trigger actor,
Externí odkaz:
https://doaj.org/article/bb669bad02bc48fc84564ad981954599
Autor:
Kamran Rizzolo, Angela Yeou Hsiung Yu, Adedeji Ologbenla, Sa Rang Kim, Haojie Zhu, Koichiro Ishimori, Guillaume Thibault, Elisa Leung, Yi Wen Zhang, Mona Teng, Marta Haniszewski, Noha Miah, Sadhna Phanse, Zoran Minic, Sukyeong Lee, Julio Diaz Caballero, Mohan Babu, Francis T. F. Tsai, Tomohide Saio, Walid A. Houry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/48ed5bf4e8a048a39dcda55f24f8469f
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9934 (2010)
Hsp90 is an essential molecular chaperone that is also a novel anti-cancer drug target. There is growing interest in developing new drugs that modulate Hsp90 activity.Using a virtual screening approach, 4-hydroxytamoxifen, the active metabolite of th
Externí odkaz:
https://doaj.org/article/d51dbe0b7e584f53987af0ccf4de3a0a
Autor:
Emily M. J. Fennell, Lucas J. Aponte‐Collazo, Joshua D. Wynn, Kristina Drizyte‐Miller, Elisa Leung, Yoshimi Endo Greer, Paul R. Graves, Andrew A. Iwanowicz, Hani Ashamalla, Ekhson Holmuhamedov, Henk Lang, Donald S. Karanewsky, Channing J. Der, Walid A. Houry, Stanley Lipkowitz, Edwin J. Iwanowicz, Lee M. Graves
Publikováno v:
Pharmacology Research & Perspectives. 10
We recently described the identification of a new class of small-molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound
Autor:
Mark F. Mabanglo, Keith S. Wong, Marim M. Barghash, Elisa Leung, Stephanie H.W. Chuang, Afshan Ardalan, Emily M. Majaesic, Cassandra J. Wong, Shen Zhang, Henk Lang, Donald S. Karanewsky, Andrew A. Iwanowicz, Lee M. Graves, Edwin J. Iwanowicz, Anne-Claude Gingras, Walid A. Houry
Publikováno v:
Structure. 31:185-200.e10
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells to eliminate reactive
Autor:
Walid A. Houry, Boxi Song, Funing Lin, Michele Cossette, Marim M Barghash, Elisa Leung, Emil F. Pai, Scott D. Gray-Owen, Gursonika Binepal, Robert A. Batey, Jazmin Bansagi, Vitor Serrão, Jordan D. Goodreid, Mark F. Mabanglo, Keith S. Wong
Publikováno v:
ACS Infectious Diseases. 6:3224-3236
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and becaus
Autor:
Adedeji Ologbenla, Noha Miah, Kamran Rizzolo, Walid A. Houry, Francis T.F. Tsai, Koichiro Ishimori, Marta Haniszewski, Sukyeong Lee, Sadhna Phanse, Julio Diaz Caballero, Elisa Leung, Yi Wen Zhang, Guillaume Thibault, Mona Teng, Zoran Minic, Haojie Zhu, Tomohide Saio, Mohan Babu, Angela Yeou Hsiung Yu, Sa Rang Kim
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
A functional association is uncovered between the ribosome-associated trigger factor (TF) chaperone and the ClpXP degradation complex. Bioinformatic analyses demonstrate conservation of the close proximity of tig, the gene coding for TF, and genes co
Autor:
Gursonika, Binepal, Mark F, Mabanglo, Jordan D, Goodreid, Elisa, Leung, Marim M, Barghash, Keith S, Wong, Funing, Lin, Michele, Cossette, Jazmin, Bansagi, Boxi, Song, Vitor Hugo, Balasco Serrão, Emil F, Pai, Robert A, Batey, Scott D, Gray-Owen, Walid A, Houry
Publikováno v:
ACS Infect Dis
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential for bacterial fitness, and becaus
Autor:
Siavash Vahidi, Elisa Leung, Emil F. Pai, Bryan T. Eger, Sadhna Phanse, Yu-Qian Mao, Vaibhav Bhandari, Mark F. Mabanglo, Jin Lin Zhou, Marim M Barghash, Robert A. Batey, Mohan Babu, Kamran Rizzolo, Thiago V. Seraphim, Steve Bryson, Walid A. Houry, Carlos H.I. Ramos, Lewis E. Kay, Leandro R.S. Barbosa, Jordan D. Goodreid
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Bacterial ClpP is a highly conserved, cylindrical, self-compartmentalizing serine protease required for maintaining cellular proteostasis. Small molecule acyldepsipeptides (ADEPs) and activators of self-compartmentalized proteases 1 (ACP1s) cause dys