Výsledky vyhledávání - "Elisa Leimgruber"

Akademický článek

Identification of CIITA regulated genetic module dedicated for antigen presentation.

Autor: Michal Krawczyk, Queralt Seguín-Estévez, Elisa Leimgruber, Peter Sperisen, Christoph Schmid, Philipp Bucher, Walter Reith

Publikováno v: PLoS Genetics, Vol 4, Iss 4, p e1000058 (2008)

The class II trans-activator CIITA is a transcriptional co-activator required for the expression of Major Histocompatibility Complex (MHC) genes. Although the latter function is well established, the global target-gene specificity of CIITA had not be

Externí odkaz: https://doaj.org/article/ab7f558434414761a7fba6cc16602506

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Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes

Autor: Isabelle Dunand-Sauthier, Walter Reith, Marie-Laure Santiago-Raber, Carla Lippens, Vishal Agrawal, Beatris Mastelic-Gavillet, Kerstin Sarter, Claire-Anne Siegrist, Fernanda V. Duraes, Florian Gobet, Giovanni Magistrelli, Ulla Ravn, Elisa Leimgruber, Stéphanie Hugues, Nicolas Fischer, Arun T. Kamath, Paola Fontannaz, Emmanuèle Barras, Leslie Guéry

Publikováno v: J Exp Med
The Journal of Experimental Medicine
The Journal of experimental medicine
Journal of Experimental Medicine, Vol. 213, No 2 (2016) pp. 177-187

Butyrophilins are proteins secreted during lactation and thought to influence immune function. Sarter et al. generated butyrophilin-2a2–deficient mice to show enhanced effector T cell responses, antitumor responses, and exacerbated EAE due to the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2a8ebd0cd6f9beb1ba6325bb8ac172
https://doi.org/10.1084/jem.20150435

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The Transcription Factor RFX Protects MHC Class II Genes against Epigenetic Silencing by DNA Methylation

Autor: Michal Krawczyk, Gianfranco Abbate, Arcangelo Nocera, Jean Villard, A. Tagliamacco, Elisa Leimgruber, Capucine Picard, Raffaele De Palma, Queralt Seguín-Estévez, Jack Gorski, Walter Reith

Publikováno v: Journal of Immunology, Vol. 183, No 4 (2009) pp. 2545-2553

Classical and nonclassical MHC class II (MHCII) genes are coregulated by the transcription factor RFX (regulatory factor X) and the transcriptional coactivator CIITA. RFX coordinates the assembly of a multiprotein “enhanceosome” complex on MHCII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b61edaf02972284ec59498b82955ec9
https://doi.org/10.4049/jimmunol.0900376

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Nucleosome eviction from MHC class II promoters controls positioning of the transcription start site

Autor: Elisa Leimgruber, Natalia Rybtsova, Queralt Seguín-Estévez, Walter Reith, Philipp Bucher, Giovanna Ambrosini, Isabelle Dunand-Sauthier, Christoph D. Schmid

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Vol. 37, No 8 (2009) pp. 2514-2528

Nucleosome depletion at transcription start sites (TSS) has been documented genome-wide in multiple eukaryotic organisms. However, the mechanisms that mediate this nucleosome depletion and its functional impact on transcription remain largely unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4099270a6678b4081bd84b2451f3e08
http://europepmc.org/articles/PMC2677874

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The dual control of TFIIB recruitment by NC2 is gene specific

Autor: Patrick Marc David Masson, Martine A. Collart, Sandrine Yolande Germaine Creton, Elisa Leimgruber

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Vol. 36, No 2 (2008) pp. 539-49

Negative co-factor 2 (NC2) is a conserved eukaryotic complex composed of two subunits, NC2alpha (Drap1) and NC2beta (Dr1) that associate through a histone-fold motif. In this work, we generated mutants of NC2, characterized target genes for these mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaa06499d18f6a0bc233c233cc5f23c
https://doi.org/10.1093/nar/gkm1078

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Transcription-coupled deposition of histone modifications during MHC class II gene activation

Autor: Walter Reith, Elisa Leimgruber, Natalia Rybtsova, Queralt Seguín-Estévez, Michal Krawczyk, Isabelle Dunand-Sauthier

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Vol. 35, No 10 (2007) pp. 3431-3441

Posttranslational histone modifications associated with actively expressed genes are generally believed to be introduced primarily by histone-modifying enzymes that are recruited by transcription factors or their associated co-activators. We have per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bc845ba5f3661b106ed2eaa92bc357
http://europepmc.org/articles/PMC1904273

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Identification of CIITA regulated genetic module dedicated for antigen presentation

Autor: Walter Reith, Peter Sperisen, Christoph D. Schmid, Michal Krawczyk, Queralt Seguín-Estévez, Elisa Leimgruber, Philipp Bucher

Publikováno v: PLoS Genetics, Vol 4, Iss 4, p e1000058 (2008)
PLoS Genetics
PLOS Genetics, Vol. 4, No 4 (2008) P. e1000058

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8113522961e7d7ba75f1008261a6799c
http://europepmc.org/articles/PMC2278383?pdf=render

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Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes

Autor: Isabelle Dunand-Sauthier, Walter Reith, Emmanuèle Barras, Michal Krawczyk, Elisa Leimgruber, Queralt Seguín-Estévez

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Vol. 35, No 2 (2007) pp. 595-605

The small GTPase RAB4 regulates endocytic recycling, a process that contributes to Major Histocompatibility Complex (MHC)-mediated antigen presentation by specialized antigen presenting cells (APC) of the immune system. The gene encoding the RAB4B is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55dd106804d8738340c151ad5a77f43
https://pubmed.ncbi.nlm.nih.gov/17175541

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