Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study.

Autor: Daniela Basso, Paola Fogar, Massimo Falconi, Elisa Fadi, Cosimo Sperti, Chiara Frasson, Eliana Greco, Domenico Tamburrino, Sara Teolato, Stefania Moz, Dania Bozzato, Michela Pelloso, Andrea Padoan, Giuseppe De Franchis, Elisa Gnatta, Monica Facco, Carlo-Federico Zambon, Filippo Navaglia, Claudio Pasquali, Giuseppe Basso, Gianpietro Semenzato, Sergio Pedrazzoli, Paolo Pederzoli, Mario Plebani

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54824 (2013)

BACKGROUND: Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating and splenic T lymphocyte and IMC subsets in patients with benign and malignant pancreatic diseases.

Externí odkaz: https://doaj.org/article/d81e9ed9c7ba4a3485d367c8f0e637da

Pancreatic tumors and immature immunosuppressive myeloid cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 and CTLA4. An in vivo and in vitro study

Autor: Dania Bozzato, Stefania Moz, Cosimo Sperti, Eliana Greco, Domenico Tamburrino, Massimo Falconi, Sara Teolato, Elisa Fadi, Gianpietro Semenzato, Daniela Basso, Elisa Gnatta, Carlo Federico Zambon, Paolo Pederzoli, Michela Pelloso, Paola Fogar, Mario Plebani, Giuseppe Basso, Sergio Pedrazzoli, Giuseppe De Franchis, Filippo Navaglia, Claudio Pasquali, Monica Facco, Andrea Padoan, Chiara Frasson

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54824 (2013)
PLoS ONE

Background Blood and spleen expansion of immature myeloid cells (IMCs) might compromise the immune response to cancer. We studied in vivo circulating and splenic T lymphocyte and IMC subsets in patients with benign and malignant pancreatic diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c3f728fb194fb81eba406e6fea01c1
http://hdl.handle.net/11577/2572945

Altered Intracellular Calcium Fluxes in Pancreatic Cancer Induced Diabetes Mellitus: Relevance of the S100A8 N-Terminal Peptide (NT-S100A8)

Autor: Filippo Navaglia, Sergio Pedrazzoli, Andrea Padoan, Eliana Greco, Carlo Reggiani, Carlo-Federico Zambon, Anna Valerio, Daniela Basso, Elisa Fadi, Dania Bozzato, Paola Fogar, Mario Plebani, Michele Scorzeto, Eugenio De Carlo, Roberta Seraglia, Stefania Moz

Publikováno v: Journal of cellular physiology
226 (2011): 456–468. doi:10.1002/jcp.22355
info:cnr-pdr/source/autori:Basso D.; Greco E.; Padoan A.; Fogar P.; Scorzeto M.; Fadi E.; Bozzato D.; Moz S.; Navaglia F.; Zambon C.; Seraglia R.; De Carlo E.; Valerio A.; Reggiani C.; Pedrazzoli S.; Plebani M./titolo:Altered Intracellular Calcium Fluxes in Pancreatic Cancer Induced Diabetes Mellitus: Relevance of the S100A8 N-Terminal Peptide (NT-S100A8)/doi:10.1002%2Fjcp.22355/rivista:Journal of cellular physiology (Print)/anno:2011/pagina_da:456/pagina_a:468/intervallo_pagine:456–468/volume:226

After isolating NT-S100A8 from pancreatic cancer (PC) tissue of diabetic patients, we verified whether this peptide alters PC cell growth and invasion and/or insulin release and [Ca(2+)](i) oscillations of insulin secreting cells and/or insulin signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392ab8d79c4be63e5f95aeffb4231399
https://publications.cnr.it/doc/48712

Heat-induced transcription of diphtheria toxin A or its variants, CRM176 and CRM197: implications for pancreatic cancer gene therapy

Autor: Filippo Navaglia, M. Sanzari, Giorgia Pantano, Lidia Moserle, Sergio Pedrazzoli, Paola Fogar, Andrea Padoan, Montecucco C, Mario Plebani, Eliana Greco, Stefano Indraccolo, Elisa Fadi, Daniela Basso, Carlo-Federico Zambon, Alessia Stranges

Publikováno v: Cancer gene therapy. 17(1)

Vectors combining the heat shock proteins (HSPs) promoter with the catalytic subunit A of the diphtheria toxin (DTA) or its variants, cross-reacting material (CRM) 176 and 197, were engineered to investigate the effect of bacterial toxins on pancreat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9d30a70ef5742ef2d987cd39dc6961
https://pubmed.ncbi.nlm.nih.gov/19609296

Clarithromycin Resistance, Tumor Necrosis Factor Alpha Gene Polymorphism and Mucosal Inflammation Affect H. pylori Eradication Success

Autor: Andrea Padoan, Sergio Pedrazzoli, Eliana Greco, Daniela Basso, Carlo-Federico Zambon, Michela Fasolo, Stefania Schiavon, Paola Fogar, Filippo Navaglia, Giacomo Carlo Sturniolo, Elisa Fadi, Alessia Stranges, Anna D'Odorico, Mario Plebani

Several bacterial and host-related factors concur in causing Helicobacter pylori eradication failure. We ascertained the role of bacterial virulence genes (cagA, vacA), clarithromycin resistance [Cla(R), 23S ribosomal RNA (rRNA) mutations], host poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ccdca5d957a5009dfd82fb9fab8506
http://hdl.handle.net/11577/2450819