Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Elisa Espinet"'
Autor:
Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Iris Moll, Elisenda Alsina-Sanchis, Hanibal Bohnenberger, Elena Fernandez-Florido, Ronja Mülfarth, Margherita Vacca, Jennifer Gerwing, Lena-Christin Conradi, Philipp Ströbel, Andreas Trumpp, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely
Externí odkaz:
https://doaj.org/article/2e93fce2b3b54b13883ba9d597b21173
Autor:
Hamed Alborzinia, Zhiyi Chen, Umut Yildiz, Florencio Porto Freitas, Felix C E Vogel, Julianna Patricia Varga, Jasmin Batani, Christoph Bartenhagen, Werner Schmitz, Gabriele Büchel, Bernhard Michalke, Jashuo Zheng, Svenja Meierjohann, Enrico Girardi, Elisa Espinet, Andrés F Flórez, Ancely Ferreira dosSantos, Nesrine Aroua, Tasneem Cheytan, Julie Haenlin, Lisa Schlicker, Thamara N Xavier da Silva, Adriana Przybylla, Petra Zeisberger, Giulio Superti‐Furga, Martin Eilers, Marcus Conrad, Marietta Fabiano, Ulrich Schweizer, Matthias Fischer, Almut Schulze, Andreas Trumpp, José Pedro Friedmann Angeli
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp n/a-n/a (2023)
Abstract Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR‐activation screens
Externí odkaz:
https://doaj.org/article/f738f088a5b24d4d84df76ffa09916f9
Autor:
Elyne Backx, Katarina Coolens, Jan-Lars Van den Bossche, Isabelle Houbracken, Elisa Espinet, Ilse Rooman
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1243-1253 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating type of cancer. While many studies have shed light into the pathobiology of PDAC, the nature of PDAC’s cell of origin remains under debate. Studies in adult pancreatic tissue have unveiled a
Externí odkaz:
https://doaj.org/article/672711a25da84b37a2c43cad208150d5
Autor:
Niklas Krebs, Lukas Klein, Florian Wegwitz, Elisa Espinet, Hans Carlo Maurer, Mengyu Tu, Frederike Penz, Stefan Küffer, Xingbo Xu, Hanibal Bohnenberger, Silke Cameron, Marius Brunner, Albrecht Neesse, Uday Kishore, Elisabeth Hessmann, Andreas Trumpp, Philipp Ströbel, Rolf A. Brekken, Volker Ellenrieder, Shiv K. Singh
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Metastatic pancreatic cancer (PDAC) has a poor clinical outcome with a 5-year survival rate below 3%. Recent transcriptome profiling of PDAC biopsies has identified 2 clinically distinct subtypes — the “basal-like” (BL) subtype with poor progno
Externí odkaz:
https://doaj.org/article/f1f4891754d64053be21530accf7b577
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In recent years, the development of ex vivo organoid cultures has gained substantial attention as a model to study regenerative medicine and diseases in several tissues. Diabetes and pancreatic ductal adenocarcinoma (PDAC) are the two major devastati
Externí odkaz:
https://doaj.org/article/61cc6764e70c4832a2d5c9150b521ef3
Autor:
Matthias Bozza, Edward W. Green, Elisa Espinet, Alice De Roia, Corinna Klein, Vanessa Vogel, Rienk Offringa, James A. Williams, Martin Sprick, Richard P. Harbottle
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 957-968 (2020)
We describe herein non-integrating minimally sized nano-S/MAR DNA vectors, which can be used to genetically modify dividing cells in place of integrating vectors. They represent a unique genetic tool, which avoids vector-mediated damage. Previous wor
Externí odkaz:
https://doaj.org/article/c209bacd632e4cabbf2898e259b2e84f
Autor:
Maria Llamazares-Prada, Elisa Espinet, Vedrana Mijošek, Uwe Schwartz, Pavlo Lutsik, Raluca Tamas, Mandy Richter, Annika Behrendt, Stephanie T. Pohl, Naja P. Benz, Thomas Muley, Arne Warth, Claus Peter Heußel, Hauke Winter, Jonathan J. M. Landry, Felix J.F. Herth, Tinne C.J. Mertens, Harry Karmouty-Quintana, Ina Koch, Vladimir Benes, Jan O. Korbel, Sebastian M. Waszak, Andreas Trumpp, David M. Wyatt, Heiko F. Stahl, Christoph Plass, Renata Z. Jurkowska
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Complexity of lung microenvironment and changes in cellular composition during disease make it exceptionally hard to understand molecular mechanisms driving development of chronic lung diseases. Although recent advances in cell type–resolved approa
Externí odkaz:
https://doaj.org/article/4b9ddf2689b3451391994aacacc3f941
Autor:
Matthias Neulinger-Muñoz, Dominik Schaack, Svetlana P. Grekova, Andrea S. Bauer, Thomas Giese, Gabriel A. Salg, Elisa Espinet, Barbara Leuchs, Anette Heller, Jürg P. F. Nüesch, Miriam Schenk, Michael Volkmar, Nathalia A. Giese
Publikováno v:
Viruses, Vol 13, Iss 6, p 1019 (2021)
Although the oncolytic parvovirus H-1PV has entered clinical trials, predicting therapeutic success remains challenging. We investigated whether the antiviral state in tumor cells determines the parvoviral oncolytic efficacy. The interferon/interfero
Externí odkaz:
https://doaj.org/article/5d5ce1a759fd45638411f8ab7d8bf8e3
Autor:
Alexandre Calon, Elisa Espinet, Sergio Palomo-Ponce, Daniele Tauriello, Mar Iglesias, María Céspedes, Marta Sevillano, Cristina Nadal, Peter Jung, Xiang Zhang, Daniel Byrom, Antoni Riera, David Rossell, Ramón Mangues, Joan Massague, Elena Sancho, Eduard Batlle
Publikováno v:
Bio-Protocol, Vol 4, Iss 9 (2014)
Metastasis depends on a gene program expressed by the tumor microenvironment upon TGF-beta stimulation. CRC (Colorectal cancer) cell lines did not induce robust stromal TGF-beta responses when injected into nude mice as shown by lack of p-SMAD2 accum
Externí odkaz:
https://doaj.org/article/6cc39bbe3e3440febc0c004e15972986
Autor:
Andreas Trumpp, Martin R. Sprick, Wilko Weichert, Oliver Strobel, Janel L. Kopp, Ilse Rooman, H. Efsun Arda, Dieter Weichenhan, Katja Steiger, Benedikt Brors, Christoph Plass, Thilo Hackert, Nicole Pfarr, Matthias Schlesner, Roland Eils, Hsi-Yu Yen, Elisa Donato, Manuel Rodríguez-Paredes, Matthias M. Gaida, Soheila Zarei, Elyne Backx, Alex Y.L. Lee, Karnjit Sarai, Alexander Muckenhuber, Steffi O. Kossi, Vera Thiel, Manuel Reitberger, Jacob Insua-Rodríguez, Mattia Falcone, Vanessa Vogel, Corinna Klein, Silke Weisenburger, Mariam Safavi, Magdalena Büscher, Nathalia A. Giese, Charles D. Imbusch, Zuguang Gu, Elisa Espinet
Supplementary Figures S1 to S15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6bcfdd799ab0ad68bc5c33c677dcd0
https://doi.org/10.1158/2159-8290.22536175.v1
https://doi.org/10.1158/2159-8290.22536175.v1