Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Elisa DeStanchina"'
Autor:
James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model. This is in contrast both to 14C‐labeled gemcitabine, and established expectat
Externí odkaz:
https://doaj.org/article/9a2617618920471fbdb6fb46405f3a90
Autor:
Radha Mukherjee, Kiran Gireesan Vanaja, Malvika Sharma, Yangjingyi Ruan Ruan, Hilla Solomon, Elisa deStanchina, Sarat Chandarlapaty, Neal Rosen
Publikováno v:
Cancer Research. 83:3882-3882
The PI3K pathway is a key regulator of metabolism, cell proliferation and migration and some of its components (e.g. PIK3CA, HER2 and PTEN) are frequently altered in cancer by genetic events that deregulate its output. However, inhibitors of componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5505ce3fe49c717b94409b7e7be2a40
https://doi.org/10.1158/1538-7445.am2023-3882
https://doi.org/10.1158/1538-7445.am2023-3882
Autor:
Rui Liang, Daisuke Tomita, Yusuke Sasaki, John Ginn, Mayako Michino, David J. Huggins, Leigh Baxt, Stacia Kargman, Maaz Shahid, Kazuyoshi Aso, Mark Duggan, Andrew W. Stamford, Elisa DeStanchina, Nigel Liverton, Peter T. Meinke, Michael A. Foley, Richard E. Phillips
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aberrant gene-silencing through dysregulation of polycomb protein activity has emerged as an important oncogenic mechanism in cancer, implicating polycomb proteins as important therapeutic targets. Recently, an inhibitor targeting E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fe1f32f4d2fdd6317d49a02ab86ed4
https://pubmed.ncbi.nlm.nih.gov/35300079
https://pubmed.ncbi.nlm.nih.gov/35300079
Autor:
Michael Offin, Jennifer L. Sauter, Jacklyn V. Egger, Elisa deStanchina, John T. Poirier, Marjorie G. Zauderer, Charles Rudin, Triparna Sen
Publikováno v:
Cancer Research. 82:51-51
Background: Despite recent treatment advances, malignant pleural mesothelioma (MPM) is an aggressive, recalcitrant malignancy. Currently, histologic subtype (epithelioid/non-epithelioid/biphasic) is the primary prognostic factor; other potential biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea9e074a915d10aa386b969bd705b5a
https://doi.org/10.1158/1538-7445.am2022-51
https://doi.org/10.1158/1538-7445.am2022-51
Autor:
Erik Herz, Andrew Burns, Hooisweng Ow, Michelle S. Bradbury, Jedd D. Wolchok, Srikant K. Iyer, David Schaer, Elisa DeStanchina, Valerie A. Longo, Steven M. Larson, Oula Penate-Medina, Pat Zanzonico, Ulrich Wiesner, Miriam Benezra
Publikováno v:
Journal of Clinical Investigation. 121:2768-2780
Nanoparticle-based materials, such as drug delivery vehicles and diagnostic probes, currently under evaluation in oncology clinical trials are largely not tumor selective. To be clinically successful, the next generation of nanoparticle agents should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0590216966f9d6b4e69c619cb42f5934
https://doi.org/10.1172/jci45600
https://doi.org/10.1172/jci45600
Autor:
Kalyani Chadalavada, Neal Rosen, Timour Baslan, Elisa DeStanchina, Gouri Nanjangud, Jorge S. Reis-Filho, Michael F. Berger, Luciano G. Martelotto, Yaohua Xue, Scott W. Lowe, Martha Solomon, Piro Lito, Alberto Vides
Publikováno v:
Molecular Cancer Therapeutics. 17:B015-B015
Tumors evolve as they adapt to environmental cues. The principles governing evolution of tumors under the selective pressure of targeted therapy are not well understood. We aimed to evaluate the evolution of resistance and to identify therapeutic mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32c49fb695255ed8b29fd13fb8e28378
https://doi.org/10.1158/1535-7163.targ-17-b015
https://doi.org/10.1158/1535-7163.targ-17-b015
Autor:
José Baselga, Jaclyn F. Hechtman, Andrea Cercek, Michael F. Berger, Neal Rosen, Elisa DeStanchina, Leonard B. Saltz, David M. Hyman, Zhan Yao, Efsevia Vakiani, David B. Solit, Rona Yaeger
Publikováno v:
Molecular Cancer Therapeutics. 14:C174-C174
Background: RAF and EGFR inhibitor combinations have shown promising clinical activity in patients with BRAF V600E colorectal cancer, but resistance invariably develops. Methods: To define mechanisms of resistance to RAF/EGFR inhibition, we analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e55724a5830276e4ea8b28ca2f51e7b9
https://doi.org/10.1158/1535-7163.targ-15-c174
https://doi.org/10.1158/1535-7163.targ-15-c174
Autor:
Iris Appelmann, Elisa DeStanchina, Gregory Carbonetti, Chong Chen, Scott W. Lowe, Charles J. Sherr
Publikováno v:
Blood. 122:1265-1265
Aggressive Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) that genetically and phenotypically mimics the human disease can be induced by the introduction of cultured p185 (BCR-ABL)-expressing Arf-null pre/pro-B cells into h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e324bf6ef45e96100979121fac5cc8
https://doi.org/10.1182/blood.v122.21.1265.1265
https://doi.org/10.1182/blood.v122.21.1265.1265
Autor:
Poulikos I. Poulikakos, Elisa DeStanchina, Madhavi Tadi, Maytal Gabay, Wai Wong, Eric W. Joseph, S Chandarlapaty, Piro Lito, Christine A. Pratilas, Neal Rosen
Publikováno v:
Cancer Research. 72:1223-1223
Activation of ERK signaling causes feedback inhibition of receptor tyrosine kinase and RAS signaling by multiple mechanisms and limits the steady-state output of the pathway. The V600E BRAF mutant does not depend on RAS-dependent dimerization and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::473314ca4f0a6283f23269d954cb86a8
https://doi.org/10.1158/1538-7445.am2012-1223
https://doi.org/10.1158/1538-7445.am2012-1223