Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Elisa De Crignis"'
Autor:
Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat). Following mutagenesis, insertions were map
Externí odkaz:
https://doaj.org/article/2f729d806387452999a3c9f51ee0ea9f
Autor:
Elisa De Crignis, Tanvir Hossain, Shahla Romal, Fabrizia Carofiglio, Panagiotis Moulos, Mir Mubashir Khalid, Shringar Rao, Ameneh Bazrafshan, Monique MA Verstegen, Farzin Pourfarzad, Christina Koutsothanassis, Helmuth Gehart, Tsung Wai Kan, Robert-Jan Palstra, Charles Boucher, Jan NM IJzermans, Meritxell Huch, Sylvia F Boj, Robert Vries, Hans Clevers, Luc JW van der Laan, Pantelis Hatzis, Tokameh Mahmoudi
Publikováno v:
eLife, Vol 10 (2021)
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for
Externí odkaz:
https://doaj.org/article/14b4dd868a334facbdb13052dadd9b22
Autor:
Mateusz Stoszko, Elisa De Crignis, Casper Rokx, Mir Mubashir Khalid, Cynthia Lungu, Robert-Jan Palstra, Tsung Wai Kan, Charles Boucher, Annelies Verbon, Emily C. Dykhuizen, Tokameh Mahmoudi
Publikováno v:
EBioMedicine, Vol 3, Iss C, Pp 108-121 (2016)
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cel
Externí odkaz:
https://doaj.org/article/63201ca417954753afb8c06cb24c4a67
Autor:
Elisa De Crignis, Tokameh Mahmoudi
Publikováno v:
Viruses, Vol 6, Iss 11, Pp 4581-4608 (2014)
The concept of eradication of the Human Immune Deficiency Virus (HIV) from infected patients has gained much attention in the last few years. While combination Anti-Retroviral Therapy (c-ART) has been extremely effective in suppressing viral replicat
Externí odkaz:
https://doaj.org/article/ae2abff7878b4a42841dcba6166a8048
Autor:
Tokameh Mahmoudi, Monique M.A. Verstegen, Tanvir Hossain, Pantelis Hatzis, Robert P. de Vries, Jan Nm IJzermans, Mir M. Khalid, Elisa De Crignis, Shahla Romal, Tsung Wai Kan, Helmuth Gehart, Christina Koutsothanassis, Luc J. W. van der Laan, Shringar Rao, Meritxell Huch, Farzin Pourfarzad, Robert-Jan Palstra, Sylvia F. Boj, Charles A. Boucher, Panagiotis Moulos, Ameneh Bazrafshan, Fabrizia Carofiglio, Hans Clevers
Publikováno v:
eLife, Vol 10 (2021)
eLife, 10. eLife Sciences Publications
eLife, 10
eLife
eLife, 10. eLife Sciences Publications
eLife, 10
eLife
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for
Autor:
Manzhi Zhao, Yvonne M. Mueller, Teun van Gelder, Casper Rokx, Annelies Verbon, Elisa De Crignis, Tokameh Mahmoudi, Peter D. Katsikis
Publikováno v:
Pharmacological Research, 139, 524-534. Academic Press
Combination antiretroviral therapy reduces morbidity and mortality in HIV infected patients. However, the cure of HIV infection is hindered by the persistence of the latent HIV reservoir. Latency reversing agents (LRAs) are developed to target the HI
Autor:
Tanvir Hossain, Hans Clevers, Jan Nm IJzermans, Shahla Romal, Mir M. Khalid, Helmuth Gehart, Christina Koutsothanassis, Elisa De Crignis, Robert P. de Vries, Ameneh Bazrafshan, Tokameh Mahmoudi, Farzin Pourfarzad, Meritxell Huch, Fabrizia Carofiglio, Tsung Wai Kan, Charles A. Boucher, Luc J. W. van der Laan, Pantelis Hatzis, Shringar Rao, Robert-Jan Palstra, Monique M.A. Verstegen, Sylvia F. Boj, Panagiotis Moulos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0a63c6ddd43cf2a084c25ff9ef971c3
https://doi.org/10.7554/elife.60747.sa2
https://doi.org/10.7554/elife.60747.sa2
Autor:
Panagiotis Moulos, Helen Bodmer, Tokameh Mahmoudi, Elisa De Crignis, Maryam Akbarzadeh, Michael D. Röling, Vaggelis Harokopos, Mahsa Mollapour Sisakht, Tsung Wai Kan, Pantelis Hatzis, Mateusz Stoszko, Robert-Jan Palstra, Enrico Ne
To identify novel host factors as putative targets to reverse HIV latency, we performed an insertional mutagenesis genetic screen in a latently HIV-1-infected pseudo-haploid KBM7 cell line (Hap-Lat). Following mutagenesis, insertions were mapped to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14e495d2584fa6cda72b18d226226c1
https://doi.org/10.1101/2021.01.20.427543
https://doi.org/10.1101/2021.01.20.427543
Autor:
Anton Škríba, Abdullah M. S. Al-Hatmi, Annelies Verbon, Vladimír Havlíček, Tokameh Mahmoudi, Elisa De Crignis, Mohammad Javad Najafzadeh, Raquel Crespo, Tsung Wai Kan, Renata Ptackova, Robert-Jan Palstra, Miroslav Sulc, Enrico Ne, Joyce Kang, Michael Roling, Casper Rokx, Elizabeth LeMasters, Peter D. Katsikis, Wilfred F. J. van IJcken, Joyce H.G. Lebbink, Sybren de Hoog, Pritha Biswas, Mateusz Stoszko, Yvonne M. Mueller, Alessia Bertoldi
Publikováno v:
Science Advances, 6
Science Advances, 6, 33
Science Advances
Science advances, 6(33):eaha6617. American Association for the Advancement of Science
Science Advances, 6, 33
Science Advances
Science advances, 6(33):eaha6617. American Association for the Advancement of Science
Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency.
A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently
A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently
Autor:
Pritha Biswas, Mateusz Stoszko, Yvonne M. Mueller, Abdullah M. S. Al-Hatmi, Wilfred F. J. van IJcken, Alessia Bertoldi, Robert-Jan Palstra, Miroslav Sulc, Joyce H.G. Lebbink, Elisa De Crignis, Sybren de Hoog, Raquel Crespo, Enrico Ne, Joyce Kang, Renata Ptackova, Anton Škríba, Peter D. Katsikis, Mohammad Javad Najafzadeh, Tokameh Mahmoudi, Annelies Verbon, Tsung Wai Kan, Vladimír Havlíček, Casper Rokx, Michael Roling
A leading pharmacological strategy towards HIV cure requires “shock” or activation of HIV gene expression in latently infected cells with Latency Reversal Agents (LRAs) followed by their subsequent clearance. In a screen for novel LRAs we used fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be8c0054b95ac123f197d740eab2420
https://doi.org/10.1101/848929
https://doi.org/10.1101/848929