Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Autor: Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito

Publikováno v: Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-19 (2019)

Abstract Background Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer’s disease. However, the molecular mechanisms underlying the synaptic and memory dys

Externí odkaz: https://doaj.org/article/084b3937ac594b9fa5e7ee6ff4bbe1d7

Tau is not necessary for amyloid-β-induced synaptic and memory impairments

Autor: Elentina K. Argyrousi, Erica Acquarone, Mauro Fa, Domenica Donatella Li Puma, Ottavio Arancio, Claudio Grassi, Hong Zhang, Elisa Calcagno, Daniela Puzzo, Luciano D'Adamio, Nicholas M. Kanaan, Elisa Zuccarello, Paul E. Fraser, Agnieszka Staniszewski

Publikováno v: J Clin Invest

The amyloid hypothesis posits that the amyloid-beta (Aβ) protein precedes and requires microtubule-associated protein tau in a sort of trigger-bullet mechanism leading to Alzheimer's disease (AD) pathology. This sequence of events has become dogmati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc239dca531de383b659778da6528b3c
https://pubmed.ncbi.nlm.nih.gov/32544084

Histone Acetyltransferase (HAT) Activator, YF2, Modulates the p53:BCL6 Axis and Antigen Presentation in Diffuse Large B-Cell Lymphomas

Autor: Edd C Ricker, Elisa Zuccarello, Brian Estrella, Jennifer E Amengual, Elisa Calcagno, Jole Fiorito, Ottavio Arancio, Yuxuan Liu, Manuel A Pazos, Barry Honig

Publikováno v: Blood. 138:2254-2254

A hallmark of DLBCL is epigenetic derangements characterized by monoallelic mutations in histone acetyltransferases (HATs); EP300 (p300) and CREBBP (CBP). The intact allele offers the opportunity for targeted therapies designed to overcome mutational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2934dbf7d87b87f2c9bc0d2329483186
https://doi.org/10.1182/blood-2021-151442

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Autor: Agnieszka Staniszewski, Erica Acquarone, Elisa Zuccarello, Jole Fiorito, Luciano D'Adamio, Shi Xian Deng, Elentina K. Argyrousi, Walter Gulisano, Mauro Fa, Manon Van Den Berg, Elisa Calcagno, Ottavio Arancio, Daniela Puzzo

Publikováno v: Molecular Neurodegeneration, 14:26. BioMed Central Ltd
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-19 (2019)

Background Soluble aggregates of oligomeric forms of tau protein (oTau) have been associated with impairment of synaptic plasticity and memory in Alzheimer’s disease. However, the molecular mechanisms underlying the synaptic and memory dysfunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5e50eb9ffec124a6f69d514f692e28
https://doi.org/10.1186/s13024-019-0326-4

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells

Autor: Mario Passalacqua, Francesca Caudano, Elisa Calcagno, Ernesto Fedele, Maria Adelaide Pronzato, Roberta Ricciarelli

Publikováno v: Mechanisms of ageing and development. 166

Long-term potentiation (LTP) and the process of memory formation require activation of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. Notably, recent evidence indicated that both cyclic nucleotides boost the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd436e5ce6c6b4940e48a3ee129e15d7
https://pubmed.ncbi.nlm.nih.gov/28789837