Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elisa Ballini"'
Autor:
Wienke Lange, Tianbo Li, Jun Chen, Eleonora Gianti, Elisia Villemure, Matthew Volgraf, Elisa Ballini, Steven Magnuson, Heike Deisemann, Tania Chernov-Rogan, Stuart Ward, Chang Liu, Andrew Peter Cridland, Vincenzo Carnevale, Xiaoyu Hu, Brian Safina, Michael L. Klein, David H. Hackos
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The TRPA1 channel functions as an irritant sensor and is a therapeutic target for treating pain, itch, and respiratory diseases. TRPA1 can be activated by electrophilic compounds via covalent modification or activated by noncovalent agon
Autor:
Marie L. Woolley, Lee A. Dawson, Elisa Ballini, Kerry A. Waters, Mark H Harries, Laura Aldegheri, Simon E. Ward, Joanne Pardoe, Laurent Lacroix, John R. Atack, Kathryn R. Starr, Annette Weil, Andrea M. Bradford
Publikováno v:
J Psychopharmacol
Purpose: There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of ionotropic glutamate receptors as therapeutic agents for a range of cognitive and mood disor
Autor:
Jodie Pang, Lunbin Deng, Girish Bankar, Jun Chen, Sultan Chowdhury, William R Proctor, Philippe Bergeron, Jennifer Vogt, Daniel F. Ortwine, Daniel P. Sutherlin, Jian Payandeh, Lilia Schumann, Shannon D. Shields, Christoph Martin Dehnhardt, Jae H. Chang, David H. Hackos, Elisa Ballini, Teresa Nguyen, Pengfei Ji, Glauco Tarozzo, Charles J. Cohen, Antonio G. DiPasquale, Kwong Wah Lai, Jonathan Maher, Kuldip Khakh, Steven J. McKerrall, Tania Chernov-Rogan, Wenfeng Liu, Brian Safina, Sophia Lin, Abid Hasan, J. P. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 62:4091-4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation
Autor:
Steven J, McKerrall, Teresa, Nguyen, Kwong Wah, Lai, Philippe, Bergeron, Lunbin, Deng, Antonio, DiPasquale, Jae H, Chang, Jun, Chen, Tania, Chernov-Rogan, David H, Hackos, Jonathan, Maher, Daniel F, Ortwine, Jodie, Pang, Jian, Payandeh, William R, Proctor, Shannon D, Shields, Jennifer, Vogt, Pengfei, Ji, Wenfeng, Liu, Elisa, Ballini, Lilia, Schumann, Glauco, Tarozzo, Girish, Bankar, Sultan, Chowdhury, Abid, Hasan, J P, Johnson, Kuldip, Khakh, Sophia, Lin, Charles J, Cohen, Christoph M, Dehnhardt, Brian S, Safina, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 62(8)
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Na
Autor:
Andrew J. Powell, SJ Medhurst, I Lago, YH Chen, Caterina Virginio, Elisa Ballini, A Buson, Laura Aldegheri, Wolfgang Jarolimek, Angelo Giacometti, Scott G. Summerfield, Corrado Carignani
Publikováno v:
British Journal of Pharmacology. 163:1315-1325
BACKGROUND AND PURPOSE P2X3 and P2X2/3 receptors are highly localized on the peripheral and central pathways of nociceptive signal transmission. The discovery of A-317491 allowed their validation as chronic inflammatory and neuropathic pain targets,
Autor:
Bela A. Patel, Yi Cui, B. Lawton, Gemma L. Ward, C. Ellis, Nick McMahon, Chris P. Doe, S. Worton, Elisa Ballini, Bronagh Heath
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:258-268
Introduction Nonclinical in vivo models used for cardiovascular safety testing have not previously been studied for their sensitivity for detection of conduction slowing resulting from cardiac sodium channel block. The goal of this study was to exami
Publikováno v:
SLAS Discovery. 5:255-261
For the identification of modulators of the metabotropic glutamate receptor mGluR7, a functional cell-based high throughput screening (HTS) assay was developed. This assay utilizes the signal transduction pathway of mGluR7, which is negatively couple
Autor:
Elisa Ballini, Benjamin D. Bax, Beatrice Oliosi, Claudette Mookherjee, Daniel Marcus Bradley, Stuart P. Ballantine, Nigel E. Austin, Kevin M. Thewlis, Rosemary A. Melarange, Shahnaz P. Yusaf, Gianni Dal Negro, Andrew Jonathan Harris, J. Mosley, Kathrine J. Smith, Laura Aldegheri, Simon E. Ward, B. Clarke, Stephen A Harrison, Mark H Harries, Patrick M. Woollard
Publikováno v:
Journal of medicinal chemistry. 54(1)
A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized from a high quality starting point hit to afford excellent developability, tolerability, and e
Autor:
Wolfgang Jarolimek, Caterina Virginio, Laura Aldegheri, Anna-Maria Capelli, Laura Castelletti, Elisa Ballini
Publikováno v:
Biophysical Journal. 98(3)
Some clinically used drugs interact via state-dependent inhibition of voltage-gated sodium channels. For example, cocaine, procaine or lidocaine preferentially interact with, and stabilize the inactivated conformation of the channel. Upon repetitive
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:200