Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Elisa Alvarez-Curto"'
Autor:
Paulius Viskaitis, Elaine E. Irvine, Mark A. Smith, Agharul I. Choudhury, Elisa Alvarez-Curto, Justyna A. Glegola, Darran G. Hardy, Silvia M.A. Pedroni, Maria R. Paiva Pessoa, Anushka B.P. Fernando, Loukia Katsouri, Alessandro Sardini, Mark A. Ungless, Graeme Milligan, Dominic J. Withers
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3559-3572 (2017)
Summary: Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in
Externí odkaz:
https://doaj.org/article/81e3234bc5b2496cb0686f51772bf269
Autor:
Kian Fan Chung, Chantal Donovan, Martha R. Tyas, Graeme Milligan, Philip M. Hansbro, Elisa Alvarez-Curto, Latifa Chachi, Davinder Kaur, Coen Wiegman, Zhaoyang Dong, Abdulrahman Ghali M. Alharbi, Andrew B. Tobin, Trond Ulven, Christopher E. Brightling, Eloise Euston, Richard Kim, Rudi Prihandoko, Jack G. Lowe
Publikováno v:
Prihandoko, R, Kaur, D, Wiegman, C H, Alvarez-Curto, E, Donovan, C, Chachi, L, Ulven, T, Tyas, M R, Euston, E, Dong, Z, Alharbi, A G M, Kim, R Y, Lowe, J G, Hansbro, P M, Chung, K F, Brightling, C E, Milligan, G & Tobin, A B 2020, ' Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 ', Science Translational Medicine, vol. 12, no. 557, 9009 . https://doi.org/10.1126/scitranslmed.aaw9009
Increased prevalence of inflammatory airway diseases including asthma and chronic obstructive pulmonary disease (COPD) together with a significant number of patients being inadequately controlled by current frontline treatments means that there is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ec3c16cfc0be37561e10eb3daf21bc
https://eprints.gla.ac.uk/225258/1/225258.pdf
https://eprints.gla.ac.uk/225258/1/225258.pdf
Autor:
Ashley M. Miller, Andrew B. Tobin, Elisa Alvarez-Curto, Graeme Milligan, Brian D. Hudson, Rudi Prihandoko, Adrian J. Butcher, Trond Ulven
Publikováno v:
Prihandoko, R, Alvarez-Curto, E, Hudson, B D, Butcher, A J, Ulven, T, Miller, A M, Tobin, A B & Milligan, G 2016, ' Distinct Phosphorylation Clusters Determine the Signaling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120 ', Molecular Pharmacology, vol. 89, no. 5, pp. 505-520 . https://doi.org/10.1124/mol.115.101949
It is established that long-chain free fatty acids includingω-3 fatty acids mediate an array of biologic responses through members of the free fatty acid (FFA) receptor family, which includes FFA4. However, the signaling mechanisms and modes of regu
Autor:
Sara Marsango, Graeme Milligan, Elisa Alvarez-Curto, Richard J. Ward, Gianluigi Caltabiano, María José Varela Liste
Publikováno v:
Molecular Pharmacology. 87:936-953
G protein-coupled receptors, including the M3 muscarinic acetylcholine receptor, can form homo-oligomers. However, the basis of these interactions and the overall organizational structure of such oligomers are poorly understood. Combinations of site-
Publikováno v:
British Journal of Pharmacology. 172:3254-3265
The free fatty acid receptors (FFA) 1 (previously designated GPR40) and FFA4 (previously GPR120) are two GPCRs activated by saturated and unsaturated longer-chain free fatty acids. With expression patterns and functions anticipated to directly or ind
Autor:
Elisa Alvarez-Curto, Suparna Patowary, Valerica Raicu, Julie A. Oliver, Graeme Milligan, Tian-Rui Xu, Jessica D. Holz
Publikováno v:
Biochemical Journal. 452:303-312
The literature on GPCR (G-protein-coupled receptor) homo-oligomerization encompasses conflicting views that range from interpretations that GPCRs must be monomeric, through comparatively newer proposals that they exist as dimers or higher-order oligo
Autor:
Elisa, Alvarez-Curto, Asuka, Inoue, Laura, Jenkins, Sheikh Zahir, Raihan, Rudi, Prihandoko, Andrew B, Tobin, Graeme, Milligan
Publikováno v:
The Journal of Biological Chemistry
G protein-coupled receptors (GPCRs) can initiate intracellular signaling cascades by coupling to an array of heterotrimeric G proteins and arrestin adaptor proteins. Understanding the contribution of each of these coupling options to GPCR signaling h
Autor:
Elisa, Alvarez-Curto, Graeme, Milligan
Publikováno v:
Biochemical pharmacology. 114
There are significant numbers of nutrient sensing G protein-coupled receptors (GPCRs) that can be found in cells of the immune system and in tissues that are involved in metabolic function, such as the pancreas or the intestinal epithelium. The famil
Autor:
Sabine Schlyer, Graeme Milligan, Laura Jenkins, Meritxell Canals, Kate Campbell, Elisa Alvarez-Curto, Sabrina de Munnik
Publikováno v:
British Journal of Pharmacology. 162:733-748
BACKGROUND AND PURPOSE GPR35 is a poorly characterized G protein-coupled receptor at which kynurenic acid has been suggested to be the endogenous ligand. We wished to test this and develop assays appropriate for the study of this receptor. EXPERIMENT
Autor:
Graeme Milligan, Gianluigi Caltabiano, Sara Marsango, Elisa Alvarez-Curto, María José Varela Liste
Publikováno v:
ResearcherID
SpringerPlus
SpringerPlus
G protein-coupled receptors, including the M3 muscarinic acetylcholine receptor and the dopamine D3 receptor, can form homo-oligomers. However, the basis of these interactions and the overall organizational structure of such oligomers are poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7410447d9e0e6723b28de6584c6015b4
https://eprints.gla.ac.uk/122348/1/122348.pdf
https://eprints.gla.ac.uk/122348/1/122348.pdf