Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Elisa, Toropainen"'
Autor:
Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 1-12 (2019)
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat
Externí odkaz:
https://doaj.org/article/623c13f35ca24a70a5117e36da09403d
Autor:
Eva Kicková, Amir Sadeghi, Jooseppi Puranen, Shirin Tavakoli, Merve Sen, Veli-Pekka Ranta, Blanca Arango-Gonzalez, Sylvia Bolz, Marius Ueffing, Stefano Salmaso, Paolo Caliceti, Elisa Toropainen, Marika Ruponen, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 12 (2021)
The treatment of retinal diseases by intravitreal injections requires frequent administration unless drug delivery systems with long retention and controlled release are used. In this work, we focused on pullulan (≈67 kDa) conjugates of dexamethaso
Externí odkaz:
https://doaj.org/article/612633861f1142a38420b60bad55386f
Autor:
Marco Bassetto, Daniel Ajoy, Florent Poulhes, Cathy Obringer, Aurelie Walter, Nadia Messadeq, Amir Sadeghi, Jooseppi Puranen, Marika Ruponen, Mikko Kettunen, Elisa Toropainen, Arto Urtti, Hélène Dollfus, Olivier Zelphati, Vincent Marion
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1650 (2021)
Barded-Biedl syndrome (BBS) is a rare genetic disorder with an unmet medical need for retinal degeneration. Small-molecule drugs were previously identified to slow down the apoptosis of photoreceptors in BBS mouse models. Clinical translation was not
Externí odkaz:
https://doaj.org/article/dcfef7fae1b1475e9c5cd6030b0df436
Autor:
Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 658 (2021)
Ocular drug absorption after eye drop instillation has been widely studied, but partitioning phenomena and spatial drug distribution are poorly understood. We investigated partitioning of seven beta-blocking drugs in corneal epithelium, corneal strom
Externí odkaz:
https://doaj.org/article/162eda48723a475a9751d6954d92caef
Autor:
Elisa Toropainen, Sara J. Fraser-Miller, Dunja Novakovic, Eva M. Del Amo, Kati-Sisko Vellonen, Marika Ruponen, Tapani Viitala, Ossi Korhonen, Seppo Auriola, Laura Hellinen, Mika Reinisalo, Unni Tengvall, Stephanie Choi, Mohammad Absar, Clare Strachan, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 452 (2021)
Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated
Externí odkaz:
https://doaj.org/article/2af1e0b88b534519bb185694d6e37fe4
Autor:
Vijayabhaskarreddy Junnuthula, Amir Sadeghi Boroujeni, Shoupeng Cao, Shirin Tavakoli, Roxane Ridolfo, Elisa Toropainen, Marika Ruponen, Jan C. M. van Hest, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 445 (2021)
Posterior eye tissues, such as retina, are affected in many serious eye diseases, but drug delivery to these targets is challenging due to various anatomical eye barriers. Intravitreal injections are widely used, but the intervals between invasive in
Externí odkaz:
https://doaj.org/article/5b4451b8b75c415c89a4c0dc5880d5fe
Autor:
Anusha Balla, Marika Ruponen, Annika Valtari, Elisa Toropainen, Marjo Tuomainen, Carmen Alvarez-Lorenzo, Eva M. del Amo, Arto Urtti, Kati-Sisko Vellonen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
Rapid precorneal loss of topically applied eye drops limits ocular drug absorption. Controlling release and precorneal residence properties of topical formulations may improve ocular drug bioavailability and duration of action. In this study, we eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d61780c7a6a2786e2d1339de42dda4
https://doi.org/10.1016/j.ejpb.2022.01.005
https://doi.org/10.1016/j.ejpb.2022.01.005
Autor:
Jaakko Itkonen, Ada Annala, Shirin Tavakoli, Blanca Arango-Gonzalez, Marius Ueffing, Elisa Toropainen, Marika Ruponen, Marco G. Casteleijn, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 611 (2020)
Ciliary neurotrophic factor (CNTF) is one of the most studied neuroprotective agents with acknowledged potential in treating diseases of the posterior eye segment. Although its efficacy and mechanisms of action in the retina have been studied extensi
Externí odkaz:
https://doaj.org/article/99494c923b1149c0bd613a2461e20a9c
Autor:
Iain Gardner, Anam Fayyaz, Kati-Sisko Vellonen, Veli-Pekka Ranta, Mika Reinisalo, Arto Urtti, Giuseppe D'Amico Ricci, Elisa Toropainen, Marika Ruponen, Jooseppi Puranen, Masoud Jamei, Emma M. Heikkinen, Eva M. del Amo, Annika Valtari
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
Quantitative understanding of pharmacokinetics of topically applied ocular drugs requires more research to further understanding and to eventually allow predictive in silico models to be developed. To this end, a topical cocktail of betaxolol, timolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071106857dbd82f3ec50430483a317c2
https://doi.org/10.1016/j.ejpb.2021.06.003
https://doi.org/10.1016/j.ejpb.2021.06.003
Autor:
Pasi Kallio, Arto Urtti, Samu Hemmilä, Marika Ruponen, Elisa Toropainen, Unni Tengvall-Unadike
Publikováno v:
Slas Technology
This paper presents a novel microflow-based concept for studying the permeability of in vitro cell models or ex vivo tissues. Using the proposed concept, we demonstrate how to maintain physiologically relevant test conditions and produce highly repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf7544ffe1b678a8f76597bb4601d0d
http://europepmc.org/articles/PMC7509603
http://europepmc.org/articles/PMC7509603