Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Elisa, Gruppioni"'
Autor:
Thais Maloberti, Antonio De Leo, Sara Coluccelli, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Francesca Comito, Barbara Melotti, Paola Valeria Marchese, Emi Dika, Federico Venturi, Barbara Corti, Giulia Ciccimarra, Crina Adriana Ciceu, Giovanni Tallini, Dario de Biase
Publikováno v:
Diagnostics, Vol 14, Iss 8, p 800 (2024)
Cutaneous melanoma is one of the most lethal tumors among skin cancers, characterized by complex genetic and molecular alterations that result in uncontrolled cell proliferation and metastatic spread. Next-generation sequencing (NGS) enables the simu
Externí odkaz:
https://doaj.org/article/2d80f900fd1f4f3f8feac42790d15777
Autor:
Thais Maloberti, Antonio De Leo, Viviana Sanza, Lidia Merlo, Michela Visani, Giorgia Acquaviva, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Stefano Zagnoni, Daniela Turchetti, Sara Miccoli, Michelangelo Fiorentino, Antonietta D’Errico, Dario de Biase, Giovanni Tallini
Publikováno v:
Journal of Molecular Pathology, Vol 3, Iss 3, Pp 115-124 (2022)
Several causes may lead to CRC, either extrinsic (sporadic forms) or genetic (hereditary forms), such as Lynch syndrome (LS). Most sporadic deficient mismatch repair (dMMR) CRC cases are characterized by the methylation of the MLH1 promoter gene and/
Externí odkaz:
https://doaj.org/article/3450d41abacb4cdbbad985255de255c7
Autor:
Dario de Biase, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Marco Grillini, Martina Ruscelli, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Daniela Turchetti, Andrea Galuppi, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Antonio De Leo
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionThe European Society of Gynecologic Oncology/European Society of Radiation Therapy and Oncology/European Society of Pathology (ESGO/ESTRO/ESP) committee recently proposed a new risk stratification system for endometrial carcinoma (EC) pat
Externí odkaz:
https://doaj.org/article/636a6ccb0216497ab54dc7a9845d8fa7
Autor:
Thais Maloberti, Antonio De Leo, Sara Coluccelli, Viviana Sanza, Elisa Gruppioni, Annalisa Altimari, Stefano Zagnoni, Francesca Giunchi, Francesco Vasuri, Michelangelo Fiorentino, Veronica Mollica, Simona Ferrari, Sara Miccoli, Michela Visani, Daniela Turchetti, Francesco Massari, Giovanni Tallini, Dario de Biase
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8940 (2023)
Despite significant therapeutic advances, metastatic CRPC (mCRPC) remains a lethal disease. Mutations in homologous recombination repair (HRR) genes are frequent in mCRPC, and tumors harboring these mutations are known to be sensitive to PARP inhibit
Externí odkaz:
https://doaj.org/article/829456da970f4a4cbb0c9c4831f630b8
Autor:
Maria A. Pantaleo, Milena Urbini, Angela Schipani, Margherita Nannini, Valentina Indio, Antonio De Leo, Bruno Vincenzi, Antonella Brunello, Giovanni Grignani, Mariaelena Casagrande, Elena Fumagalli, Elena Conca, Maristella Saponara, Elisa Gruppioni, Annalisa Altimari, Dario De Biase, Giovanni Tallini, Gloria Ravegnini, Daniela Turchetti, Marco Seri, Andrea Ardizzoni, Paola Secchiero, Annalisa Astolfi
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundSDH-deficient gastrointestinal stromal tumors (GIST) account for 20–40% of all KIT/PDGFRA-negative GIST and are due to mutations in one of the four SDH-complex subunits, with SDHA mutations as the most frequent. Here we sought to evaluate
Externí odkaz:
https://doaj.org/article/2b333e1899ab413d8278b59ee9ae4ebf
Autor:
Antonio De Leo, Daniela Serban, Thais Maloberti, Viviana Sanza, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Federico Chiarucci, Angelo Gianluca Corradini, Andrea Repaci, Alessandra Colapinto, Margherita Nannini, Maria A. Pantaleo, Dario de Biase, Giovanni Tallini
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4057 (2023)
The BRAF p.V600E mutation represents the most specific marker for papillary thyroid carcinoma and is potentially related to aggressive behavior and persistent disease. BRAF alterations other than the p.V600E are less common in thyroid carcinoma and r
Externí odkaz:
https://doaj.org/article/a9bf3e1dbdd64db0be456f820e6d7eff
Autor:
Valentina Indio, Gloria Ravegnini, Annalisa Astolfi, Milena Urbini, Maristella Saponara, Antonio De Leo, Elisa Gruppioni, Giuseppe Tarantino, Sabrina Angelini, Andrea Pession, Maria Abbondanza Pantaleo, Margherita Nannini
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in only about 5–7% of gastrointestinal stromal tumors (GIST), notably with alterations on exons 12/14/18. The most frequent PDGFRA mutation is the exon 18 D842V, which is correl
Externí odkaz:
https://doaj.org/article/0803a25f2aaf4f31ae3595789764c091
Autor:
Margherita Nannini, Di Scioscio Valerio, Elisa Gruppioni, Annalisa Altimari, Benedetta Chiusole, Maristella Saponara, Maria Abbondanza Pantaleo, Antonella Brunello
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 13 (2020)
Up to 13% of KIT and PDGFRA wild-type (WT) gastrointestinal stromal tumours (GIST) harbour a BRAF mutation, mostly involving the exon 15 V600E hot spot. Even if BRAF mutation is recognized as druggable target in other solid tumours, currently advance
Externí odkaz:
https://doaj.org/article/70147d386f204f1cb5e8945b3790b6d3
Unusual bilateral ovarian metastases from ileal gastrointestinal stromal tumor (GIST): a case report
Autor:
Antonio De Leo, Margherita Nannini, Giulia Dondi, Donatella Santini, Milena Urbini, Elisa Gruppioni, Pierandrea De Iaco, Anna Myriam Perrone, Maria Abbondanza Pantaleo
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-5 (2018)
Abstract Background Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare. Case Presentation A
Externí odkaz:
https://doaj.org/article/16ec0bdff5434d42a7ba2029887c0805
Autor:
Francesca Ruzzi, Stefania Angelicola, Lorena Landuzzi, Elena Nironi, Maria Sofia Semprini, Laura Scalambra, Annalisa Altimari, Elisa Gruppioni, Michelangelo Fiorentino, Francesca Giunchi, Manuela Ferracin, Annalisa Astolfi, Valentina Indio, Andrea Ardizzoni, Francesco Gelsomino, Patrizia Nanni, Pier-Luigi Lollini, Arianna Palladini
Publikováno v:
Translational Lung Cancer Research. 11:2216-2229
(NSCLCs). Several tyrosine kinase inhibitors (TKIs) have shown high efficacy in patients whose tumors harbour a ROS1 fusion. However, the limited availability of preclinical models of ROS1-positive NSCLC hinders the discovery of new drugs and the und