Zobrazeno 1 - 10
of 605
pro vyhledávání: '"Elisa, De Stanchina"'
Autor:
Tanaya Roychowdhury, Seth W. McNutt, Chiranjeevi Pasala, Hieu T. Nguyen, Daniel T. Thornton, Sahil Sharma, Luke Botticelli, Chander S. Digwal, Suhasini Joshi, Nan Yang, Palak Panchal, Souparna Chakrabarty, Sadik Bay, Vladimir Markov, Charlene Kwong, Jeanine Lisanti, Sun Young Chung, Stephen D. Ginsberg, Pengrong Yan, Elisa De Stanchina, Adriana Corben, Shanu Modi, Mary L. Alpaugh, Giorgio Colombo, Hediye Erdjument-Bromage, Thomas A. Neubert, Robert J. Chalkley, Peter R. Baker, Alma L. Burlingame, Anna Rodina, Gabriela Chiosis, Feixia Chu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The intricate network of protein-chaperone interactions is crucial for maintaining cellular function. Recent discoveries have unveiled the existence of specialized chaperone assemblies, known as epichaperomes, which serve as scaffolding plat
Externí odkaz:
https://doaj.org/article/2f7ed5a1fa2f46d69f151277d59c0181
Autor:
Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-8 (2024)
Externí odkaz:
https://doaj.org/article/72dc812c45684b82a3cf97701d1a5efe
Autor:
Esther Redin, Harsha Sridhar, Yingqian A. Zhan, Barbara Pereira Mello, Hong Zhong, Vidushi Durani, Amin Sabet, Parvathy Manoj, Irina Linkov, Juan Qiu, Richard P. Koche, Elisa de Stanchina, Maider Astorkia, Doron Betel, Álvaro Quintanal-Villalonga, Charles M. Rudin
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Introduction Small Cell Lung Cancer (SCLC) can be classified into transcriptional subtypes with distinct degrees of neuroendocrine (NE) differentiation. Recent evidence supports plasticity among subtypes with a bias toward adoption of low-NE
Externí odkaz:
https://doaj.org/article/863d3755b2ea4eb2a85f6bb551cf6172
Autor:
Alvaro Quintanal-Villalonga, Kenta Kawasaki, Esther Redin, Fathema Uddin, Swanand Rakhade, Vidushi Durani, Amin Sabet, Moniquetta Shafer, Wouter R. Karthaus, Samir Zaidi, Yingqian A. Zhan, Parvathy Manoj, Harsha Sridhar, Dennis Kinyua, Hong Zhong, Barbara P. Mello, Metamia Ciampricotti, Umesh K. Bhanot, Irina Linkov, Juan Qiu, Radhika A. Patel, Colm Morrissey, Sanjoy Mehta, Jesse Barnes, Michael C. Haffner, Nicholas D. Socci, Richard P. Koche, Elisa de Stanchina, Sonia Molina-Pinelo, Sohrab Salehi, Helena A. Yu, Joseph M. Chan, Charles M. Rudin
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurren
Externí odkaz:
https://doaj.org/article/501fe4c8a5e9423ca573e0d9f455d0b2
Autor:
Hidenori Kitai, Philip H. Choi, Yu C. Yang, Jacob A. Boyer, Adele Whaley, Priya Pancholi, Claire Thant, Jason Reiter, Kevin Chen, Vladimir Markov, Hirokazu Taniguchi, Rui Yamaguchi, Hiromichi Ebi, James Evans, Jingjing Jiang, Bianca Lee, David Wildes, Elisa de Stanchina, Jacqueline A. M. Smith, Mallika Singh, Neal Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Current KRASG12C (OFF) inhibitors that target inactive GDP-bound KRASG12C cause responses in less than half of patients and these responses are not durable. A class of RASG12C (ON) inhibitors that targets active GTP-bound KRASG12C blocks ERK
Externí odkaz:
https://doaj.org/article/7ad6de68f66945a2a3cb9c50ceaaf9b5
Autor:
Christopher S. Hackett, Daniel Hirschhorn, Meixian S. Tang, Terence J. Purdon, Yacine Marouf, Alessandra Piersigilli, Narasimhan P. Agaram, Cailian Liu, Sara E. Schad, Elisa de Stanchina, Sarwish Rafiq, Sebastien Monette, Jedd D. Wolchok, Taha Merghoub, Renier J. Brentjens
Publikováno v:
Molecular Therapy: Oncology, Vol 32, Iss 3, Pp 200862- (2024)
Despite therapeutic efficacy observed with immune checkpoint blockade in advanced melanoma, many tumors do not respond to treatment, representing a need for new therapies. Here, we have generated chimeric antigen receptor (CAR) T cells targeting TYRP
Externí odkaz:
https://doaj.org/article/50d77f52a8984498bb99701a99596c2c
Autor:
Alan W Long, Hong Xu, Brian H Santich, Hongfen Guo, Sayed Shahabuddin Hoseini, Elisa de Stanchina, Nai-Kong V Cheung
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-17 (2024)
Abstract Background EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR or HER2xHER2) and heterodimeric (EGFRxHER2) T cell-engaging bispecific antibodies (T-BsAbs) to direct polyclo
Externí odkaz:
https://doaj.org/article/dcaf158cf6e446219ea7f5cc9f7a96cb
Autor:
Yanping Yang, Huan Yang, Yago Alcaina, Janusz Puc, Alyssa Birt, Yogindra Vedvyas, Michael Gallagher, Srinija Alla, Maria Cristina Riascos, Jaclyn E. McCloskey, Karrie Du, Juan Gonzalez-Valdivieso, Irene M. Min, Elisa de Stanchina, Matt Britz, Eric von Hofe, Moonsoo M. Jin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The limited number of targetable tumor-specific antigens and the immunosuppressive nature of the microenvironment within solid malignancies represent major barriers to the success of chimeric antigen receptor (CAR)-T cell therapies. Here, us
Externí odkaz:
https://doaj.org/article/1773c1a113ad431dbfb194f4da0fc107
Autor:
Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Genomic instability occurs infrequently in in diffuse large B cell lymphoma (DLBCL), suggesting a therapeutic vulnerability. Here, the authors identify a synergistic combination between the induction of polyploidy by a PLK4 inhibitor and a BCL-2 inhi
Externí odkaz:
https://doaj.org/article/10d2ea4c9cf4467884462bb93e66c548
Autor:
Walid K. Chatila, Henry Walch, Jaclyn F. Hechtman, Sydney M. Moyer, Valeria Sgambati, David M. Faleck, Amitabh Srivastava, Laura Tang, Jamal Benhamida, Dorina Ismailgeci, Carl Campos, Fan Wu, Qing Chang, Efsevia Vakiani, Elisa de Stanchina, Martin R. Weiser, Maria Widmar, Rhonda K. Yantiss, Manish A. Shah, Adam J. Bass, Zsofia K. Stadler, Lior H. Katz, Ingo K. Mellinghoff, Nilay S. Sethi, Nikolaus Schultz, Karuna Ganesh, David Kelsen, Rona Yaeger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Colitis-associated cancers (CACs) develop in patients with inflammatory bowel disease and have distinct genomic features compared to sporadic colorectal cancers. Here, the authors characterize the genomic alterations of CAC tumors and dysplasia, find
Externí odkaz:
https://doaj.org/article/a4643e58f86e4dc1a8afd07151be6e8c