Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elisé P. Wright"'
Autor:
Mahmoud A. S. Abdelhamid, Nicole M. Smith, Melanie C Grigg, Zoë A. E. Waller, Michelle O Ehiabor, Kelly L. Irving, Elisé P. Wright
Publikováno v:
Nucleic Acids Research
i-Motifs are widely used in nanotechnology, play a part in gene regulation and have been detected in human nuclei. As these structures are composed of cytosine, they are potential sites for epigenetic modification. In addition to 5-methyl- and 5-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e2239fe6770170f97d617be589752d
https://doi.org/10.1093/nar/gkz1082
https://doi.org/10.1093/nar/gkz1082
Publikováno v:
Biochemistry. 56(36)
Both 5-aza-2'-deoxycytidine (decitabine) and its primary breakdown product, 2'-deoxyriboguanylurea (GuaUre-dR), have been shown to act as mutagens and epimutagens that cause replication stress and alter both DNA methylation and gene expression patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2801ae8008c55a9879f36cbf028052a5
https://pubmed.ncbi.nlm.nih.gov/28853563
https://pubmed.ncbi.nlm.nih.gov/28853563
Publikováno v:
Nucleic Acids Research
i-Motifs are alternative DNA secondary structures formed in cytosine-rich sequences. Particular examples of these structures, traditionally assumed to be stable only at acidic pH, have been found to form under near-physiological conditions. To determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a2adbd79f0b8be79dada0caf1ad26c
https://ueaeprints.uea.ac.uk/id/eprint/62822/
https://ueaeprints.uea.ac.uk/id/eprint/62822/
Autor:
Zoë A. E. Waller, Henry A. Day, Klaus Pors, Leo J. E. Boswell, Ali Ibrahim, Clare E. M. Stevenson, Elisé P. Wright, Jeethendra Kumar, Camille Huguin
Publikováno v:
Scientific Reports
There are hundreds of ligands which can interact with G-quadruplex DNA, yet very few which target i-motif. To appreciate an understanding between the dynamics between these structures and how they can be affected by intervention with small molecule l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47e824e542ac473b93d1081bc77d99b
https://doi.org/10.1038/srep39456
https://doi.org/10.1038/srep39456
Publikováno v:
Chemical Communications (Cambridge, England)
i-Motif forming DNA sequences have previously been used for many different nanotechnological applications, but all have used changes in pH to fold the DNA. Here it is shown that Cu(ii) cations can be used to re-fold i-motifs into hairpin structures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6adafacb1e3906d0b88b42e0c082aa
https://pubmed.ncbi.nlm.nih.gov/26252811
https://pubmed.ncbi.nlm.nih.gov/26252811
Autor:
Elise P. Wright, Matthew P. Padula, Vincent J. Higgins, Janice R. Aldrich-Wright, Jens R. Coorssen
Publikováno v:
Proteomes, Vol 2, Iss 4, Pp 501-526 (2014)
Many clinically available anticancer compounds are designed to target DNA. This commonality of action often yields overlapping cellular response mechanisms and can thus detract from drug efficacy. New compounds are required to overcome resistance mec
Externí odkaz:
https://doaj.org/article/b182f5a1d6ba4678b379498d1c20d156