Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Elirosa Minniti"'
Autor:
Emanuele Porru, Filomena Piro, Rossana Comito, Anastasiia Mosendz, Elirosa Minniti, Matteo Conti, Alessandra Stancari, Francesco Saverio Violante
Publikováno v:
Separations, Vol 10, Iss 9, p 517 (2023)
Idebenone (IDB) (2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone) is a compound synthesized in the early 1980s. Initially developed for the treatment of cognitive disturbances and Alzheimer’s disease, IDB is now studied for Friedreich
Externí odkaz:
https://doaj.org/article/5d4b921cb0c14d529dcfa57b9f5fc9f7
Autor:
Marco De Vivo, Jose M. Arencibia, Vito Genna, Maria Summa, Sine Mandrup Bertozzi, Elirosa Minniti, Andrea Armirotti, Sebastian Franco-Ulloa, Jo Ann W. Byl, Claudia Sissi, Rosalia Bertorelli, Neil Osheroff, Marco Borgogno, Anna Minarini, Jose Antonio Ortega
Publikováno v:
J Med Chem
We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In contrast to topoII-targeted drugs currently in clinical use, these compounds do not act as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bc28cb9ef7c7a4bbe71fd55bf4856c
http://hdl.handle.net/11577/3367154
http://hdl.handle.net/11577/3367154
Autor:
Maria Luisa Di Paolo, Giorgio Cozza, Andrea Milelli, Francesca Zonta, Stefania Sarno, Elirosa Minniti, Michela Rosini, Anna Minarini
Benextramine is a well kown tetraamine disulfide acting as irreversible α-adrenergic antagonist and able to hit additional targets involved in neurodegeneration, such as nicotinic and muscarinic receptors and acetylcholinesterase enzyme. The disulfi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4094::5e3fef7527396d95af4b066bb530c4a1
http://hdl.handle.net/11585/675870
http://hdl.handle.net/11585/675870
Autor:
Marco De Vivo, Jose M. Arencibia, Anna Minarini, Elirosa Minniti, Laura Riccardi, José-Antonio Ortega, Maria Laura Greco, Marco Borgogno, Claudia Sissi
Publikováno v:
Journal of medicinal chemistry 61(3), 1375-1379 (2018). doi:10.1021/acs.jmedchem.7b01388
We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b64610b2730c846caff92ffb359ac
https://doi.org/10.1021/acs.jmedchem.7b01388
https://doi.org/10.1021/acs.jmedchem.7b01388
Autor:
Andrea Milelli, Maria Luisa Di Paolo, Elirosa Minniti, Francesca Zonta, Michela Rosini, Anna Minarini, Giorgio Cozza, Stefania Sarno, Fulvio Ursini
Publikováno v:
The FEBS journalReferences. 286(24)
The two human monoamine oxidase isoforms (namely MAO A and MAO B) are enzymes involved in the catabolism of monoamines, including neurotransmitters, and for this reason are well-known and attractive pharmacological targets in neuropsychiatric and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345cb12cfd04a4963c050112fef35092
https://pubmed.ncbi.nlm.nih.gov/31291696
https://pubmed.ncbi.nlm.nih.gov/31291696
Autor:
Princess Onuorah, Anna Minarini, Marco De Vivo, Kendra R. Vann, Elirosa Minniti, Neil Osheroff, Alexandria A. Oviatt, Jissy A. Kuriappan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Etoposide is an anticancer drug that acts by inducing topoisomerase II-mediated DNA cleavage. Despite its wide use, etoposide is associated with some very serious side-effects including the development of treatment-related acute myelogenous leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b736d6f326afa297697b207c664276de
https://europepmc.org/articles/PMC6097886/
https://europepmc.org/articles/PMC6097886/
Autor:
Neil Osheroff, Jo Ann W. Byl, Elirosa Minniti, Anna Minarini, Michela Rosini, Marco De Vivo, Laura Riccardi, Claudia Sissi
It has been proposed that xanthone derivatives with anticancer potential act as topoisomerase II inhibitors because they interfere with the ability of the enzyme to bind its ATP cofactor. In order to further characterize xanthone mechanism and genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ef951f9950872efd38dc218d081c99
http://hdl.handle.net/11585/616539
http://hdl.handle.net/11585/616539
Autor:
Maria Laura Greco, Marino Convertino, Michela Rosini, Elena Simoni, Claudia Sissi, Laura Riccardi, Elirosa Minniti, Chiara Marchetti, Giulia Palermo, Anna Minarini, Marco De Vivo
Publikováno v:
Chemical communications 51(76), 14310-14313 (2015). doi:10.1039/C5CC05065K
Combined computational-experimental analyses explain and quantify the spermine-vectorized F14512's boosted potency as a topoII poison. We found that an optimized polyamine moiety boosts drug binding to the topoII/DNA cleavage complex, rather than to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c233e50de5002b899b16b97ae47d4aad
https://pubmed.ncbi.nlm.nih.gov/26234198
https://pubmed.ncbi.nlm.nih.gov/26234198