Incidence and determinants of adverse events in individuals with HIV commencing Dolutegravir-based antiretroviral therapy in mainland Tanzania

Autor: Adam Fimbo, Yonah H. Mwalwisi, Kissa Mwamwitwa, Damas Matiko, Elirehema Mfinanga, Johnson Lyimo, Amon Sabasaba, Seth Missago, Elias Bukundi, Goodluck Gotora, Dorice Respick, Alex Nkayamba, Emmanuel Masunga, Rajabu Hussein Mnkugwe, Peter P. Kunambi, Castory Munishi, Christine Chiedza Musanhu, Omary M. S. Minzi, Eulambius M. Mlugu

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Tanzania adopted a Dolutegravir (DTG)-based regimen as first-line treatment in 2019 following the World Health Organization recommendation. Data on the DTG safety profile from sub-Saharan Africa including Tanzania are limited. We investigate

Externí odkaz: https://doaj.org/article/ea7b4164469246fb93a1c4f5c70cff76

Pulmonary aspergilloma: a treatment challenge in sub-Saharan Africa.

Autor: Christian Pohl, Levan Jugheli, Fredrick Haraka, Elirehema Mfinanga, Khadija Said, Klaus Reither

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2352 (2013)

Externí odkaz: https://doaj.org/article/d3bac2b1ec4e46e7bc38ef0bbe56a428

Assessment of the novel T-cell activation marker–tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study

Autor: Felicien Moukambi, Fred Lwilla, Elmar Saathoff, Khadija Said, Asli Bauer, Frederick Haraka, Andrea Rachow, Mkunde Chachage, Damien Portevin, Christof Geldmacher, Ben J. Marais, Levan Jugheli, Nyanda E. Ntinginya, Claudia Daubenberger, Klaus Reither, Michael Hoelscher, Petra Clowes, Elirehema Mfinanga, Maximilian Mpina

Publikováno v: The Lancet Infectious Diseases. 14:931-938

Summary Background The diagnosis of paediatric tuberculosis is complicated by non-specific symptoms, difficult specimen collection, and the paucibacillary nature of the disease. We assessed the accuracy of a novel immunodiagnostic T-cell activation m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353733022f1b9cbae265463636d5947e
https://doi.org/10.1016/s1473-3099(14)70884-9

Towards host-directed therapies for tuberculosis

Autor: Abraham Aseffa, Alimuddin Zumla, Leonard Maboko, Gita Ramjee, Timothy D. McHugh, Robert S. Wallis, Marco Schito, Neil A. Martinson, Stefan H. E. Kaufmann, Niaina Rakotosamimanana, Ian Sanne, Sayoki Mfinanga, Roxana Rustomjee, Francine Ntoumi, Voahangy Rasolofo, Cristina Vilaplana, Gibson S. Kibiki, Salim Abdulla, Nathan Kapata, Klaus Reither, Jeremiah Chakaya, Vanya Gant, Sebastien Gagneux, Michael Hoelscher, Bongani M. Mayosi, Mahdad Noursadeghi, Nesri Padayatchi, Giuseppe Ippolito, Tandakha Ndiaye Dieye, Sarah Edwards, Eleni Aklillu, James B.W. Russell, Elirehema Mfinanga, Christian Wejse, Pontiano Kaleebu, Martin Rao, Modest Mulenga, Martin P. Grobusch, Peter Mwaba, Maryline Bonnet, Eskild Petersen, Eusebio Macete, Matthew Bates, Robert J. Wilkinson, Alberto L. García-Basteiro, Thomas Nyirenda, Dorothy Yeboah-Manu, Nalini Singh, Almoustapha Issiaka Maiga, Rajhmun Madansein, Paula Munderi, Clara Menendez, Pere-Joan Cardona, Gavin J. Churchyard, Tumena Corrah, Paul T. Elkington, Aziz Sheikh, Martin Antonio, Andrie Steyn, Leopold D. Tientcheu, Bassirou Diarra, Matt Oliver, Markus Maeurer, Gill Craig, Shreemanta Parida

Publikováno v: Nature reviews. Drug discovery, 14(8), 511-512. Nature Publishing Group
Zumla, A, Chakaya, J, Hoelscher, M, Ntoumi, F, Rustomjee, R, Vilaplana, C, Yeboah-Manu, D, Rasolof, V, Munderi, P, Singh, N, Aklillu, E, Padayatchi, N, Macete, E, Kapata, N, Mulenga, M, Kibiki, G, Mfinanga, S, Nyirenda, T, Maboko, L, Garcia-Basteiro, A, Rakotosamimanana, N, Bates, M, Mwaba, P, Reither, K, Gagneux, S, Edwards, S, Mfinanga, E, Abdulla, S, Cardona, P-J, Russell, J B W, Gant, V, Noursadeghi, M, Elkington, P, Bonnet, M, Menendez, C, Dieye, T N, Diarra, B, Maiga, A, Aseffa, A, Parida, S, Wejse, C, Petersen, E, Kaleebu, P, Oliver, M, Craig, G, Corrah, T, Tientcheu, L, Antonio, M, Rao, M, McHugh, T D, Sheikh, A, Ippolito, G, Ramjee, G, Kaufmann, S H E, Churchyard, G, Steyn, A, Grobusch, M, Sanne, I, Martinson, N, Madansein, R, Wilkinson, R J, Mayosi, B, Schito, M, Wallis, R S & Maeurer, M 2015, ' Towards host-directed therapies for tuberculosis ', Nature Reviews. Drug Discovery, vol. 14, no. 8, pp. 511-2 . https://doi.org/10.1038/nrd4696
Nature reviews. Drug discovery

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.\ud \ud Despite the ava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b666728b4f3be31f147adf7549f0e0ac

Xpert MTB/RIF assay for diagnosis of pulmonary tuberculosis in children: a prospective, multi-centre evaluation

Autor: Christina Manyama, Levan Jugheli, Daniel Mapamba, Andrea Rachow, Amanda Ross, Daniela Maria Cirillo, Fred Lwilla, Elirehema Mfinanga, Mohamed Sasamalo, Klaus Reither, Martin Nsubuga, Andreas Steiner, Francesco Aloi, Petra Clowes

Publikováno v: The Journal of infection. 70(4)

Summary Background Following endorsement by the World Health Organisation, the Xpert MTB/RIF assay has been widely incorporated into algorithms for the diagnosis of adult tuberculosis (TB). However, data on its performance in children remain scarce.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5549f1f72bcdffb93c931a7fbaf4d23b
https://pubmed.ncbi.nlm.nih.gov/25312863