Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eliot Sugarman"'
Autor:
Aiste Dobrovolskaite, Holly Moots, Mukund P. Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M. Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel
Publikováno v:
Journal of medicinal chemistry. 65(22)
Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5048172ae7721fd307b0c1dc01dcba9b
https://pubmed.ncbi.nlm.nih.gov/36382923
https://pubmed.ncbi.nlm.nih.gov/36382923
Autor:
Satyamaheshwar Peddibhotla, R. Jason Kirby, Siobhan Malany, E. Hampton Sessions, Eliot Sugarman, Camilo J. Morfa, Layton H. Smith, Patrick R. Maloney, David B. Terry, Daniela B. Divlianska, Anthony B. Pinkerton, Paul Hershberger
Publikováno v:
Bioorg Med Chem Lett
The chemokine system plays an important role in mediating a proinflammatory microenvironment for tumor growth in hepatocellular carcinoma (HCC). The CXCR6 receptor and its natural ligand CXCL16 are expressed at high levels in HCC cell lines and tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62936acf1e6bf674557060824dcd7804
https://pubmed.ncbi.nlm.nih.gov/31882297
https://pubmed.ncbi.nlm.nih.gov/31882297
Autor:
Daniel P. Kelly, Jian Liang Li, Eliot Sugarman, Rick B. Vega, Miao Wang, Gregory P. Roth, Mangala M. Soundarapandian, Jeanne Brooks, Teresa C. Leone, Ada Koo, Byung Yong Ahn, Satyamaheshwar Peddibhotla, Hampton Sessions, Siobhan Malany, Xianlin Han, Kyungmoo Yea
Publikováno v:
Journal of Clinical Investigation. 126:3567-3579
Intramuscular lipid accumulation is a common manifestation of chronic caloric excess and obesity that is strongly associated with insulin resistance. The mechanistic links between lipid accumulation in myocytes and insulin resistance are not complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c3e2dd8a4edf90b872d293d0992ab8
https://doi.org/10.1172/jci87382
https://doi.org/10.1172/jci87382
Autor:
Becky Hood, Larry S. Barak, Glen R. Hanson, Patrick R. Maloney, Kevin Nguyen, Stefan Vasile, Sumeet Salaniwal, Marc G. Caron, Yujie Li, Satyamaheshwar Peddibhotla, Derek Stonich, Alka Mehta, Anthony B. Pinkerton, Susanne Heynen-Genel, Thomas D.Y. Chung, Eigo Suyama, Wilson Gray, Palak Gosalia, Michael Vicchiarelli, Arianna Mangravita-Novo, Gregory P. Roth, Paul Hershberger, Layton H. Smith, Monika Milewski, Michael P Hedrick, Ying Su, Eliot Sugarman, James B. Thomas
Publikováno v:
ACS Medicinal Chemistry Letters. 4:846-851
The neurotensin 1 receptor (NTR1) is an important therapeutic target for a range of disease states including addiction. A high-throughput screening campaign, followed by medicinal chemistry optimization, led to the discovery of a nonpeptidic β-arres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143627f4f81a585cb759eaff5eff0002
https://doi.org/10.1021/ml400176n
https://doi.org/10.1021/ml400176n
Autor:
Anthony B. Pinkerton, Gregory P. Roth, Eigo Suyama, Layton H. Smith, Becky Hood, Danielle McAnally, Esther Jortzik, Thomas D.Y. Chung, Palak Gosalia, Michael Vicchiarelli, Arianna Mangravita-Novo, Satyamaheshwar Peddibhotla, Jena Diwan, Stefan Rahlfs, Eduard Sergienko, Paul Hershberger, Kevin Nguyen, Stefan Vasile, Katja Becker, Patrick R. Maloney, Monika Milewski, Yujie Linda Li, Michael P Hedrick, Eliot Sugarman, Janina Preuss, Lars Bode
Publikováno v:
Journal of Medicinal Chemistry. 55:7262-7272
A high-throughput screen of the NIH’s MLSMR collection of ∼340000 compounds was undertaken to identify compounds that inhibit Plasmodium falciparum glucose-6-phosphate dehydrogenase (PfG6PD). PfG6PD is important for proliferating and propagating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11e75999a27d5c7f27e1368bcea2786e
https://doi.org/10.1021/jm300833h
https://doi.org/10.1021/jm300833h
Autor:
Anthony J. Milici, Feng Gao, Francesca Zimetti, Patricia-Ann Bourassa, George H. Rothblat, Eliot Sugarman, Thomas Sand, Lee A. Morehouse
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1263-1272 (2007)
Cholesteryl ester transfer protein (CETP) inhibitors increase high density lipoprotein-cholesterol (HDL-C) in animals and humans, but whether CETP inhibition will be antiatherogenic is still uncertain. We tested the CETP inhibitor torcetrapib in rabb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd184fdfc8ce3e488737745c46610e
http://www.sciencedirect.com/science/article/pii/S0022227520425544
http://www.sciencedirect.com/science/article/pii/S0022227520425544
Autor:
Linda S. Wood, Maruja E. Lira, Thomas B. Freeman, David B. Lloyd, Gregory M. Preston, L. Kathryn Durham, Patrice M. Milos, Anthony J. Lanzetti, Peter C. Bonnette, Xiayang Qiu, John F. Thompson, Eliot Sugarman
Publikováno v:
Journal of Biological Chemistry. 280:14918-14922
Cholesteryl ester transfer protein (CETP) is an important modulator of high density lipoprotein cholesterol in humans and thus considered to be a therapeutic target for preventing cardiovascular disease. The gene encoding CETP has been shown to be hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaf58c993324f1feb8b32720e84e401
https://doi.org/10.1074/jbc.m500523200
https://doi.org/10.1074/jbc.m500523200
Autor:
Patricia G. Cosgrove, Ronald W. Clark, Ann T. Willauer, John A. Williams, Michael Ellis Perlman, Roger B. Ruggeri, Eliot Sugarman, Thomas Sand, Mark J. Bamberger, Tamara Sutfin, Wester Ronald Thure, Magnus-Aryitey George Tetteh
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 24:490-497
Objective— The ability of the potent cholesteryl ester transfer protein (CETP) inhibitor torcetrapib (CP-529,414) to raise high-density lipoprotein cholesterol (HDL-C) levels in healthy young subjects was tested in this initial phase 1 multidose st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba7d87eaf94371bd7a185926d08c037
https://doi.org/10.1161/01.atv.0000118278.21719.17
https://doi.org/10.1161/01.atv.0000118278.21719.17
Autor:
Lawrence M. Zaccaro, Theresa C. Wilson, Mccarthy Peter A, Faan-Wen Bangerter, Charles E. Chandler, Michael P. DeNinno, R.W. Wilkins, Heidi A. Woody, Lee A. Morehouse, Judith L. Pettini, Yvette E. Savoy, Philip B. Inskeep, Eliot Sugarman
Publikováno v:
Journal of Lipid Research. 40:464-474
The hypocholesterolemic activities of pamaqueside and tiqueside, two structurally similar saponins, were evaluated in cholesterol-fed rabbits. The pharmacological profiles of the saponins were virtually identical: both dose-dependently decreased the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b43d4f032357a817090b9979fccd35df
https://doi.org/10.1016/s0022-2275(20)32451-2
https://doi.org/10.1016/s0022-2275(20)32451-2
Autor:
Charles E. Chandler, Michael P. Zawistoski, R.W. Wilkins, Heidi A. Woody, Michael P. DeNinno, Eliot Sugarman, John B. Etienne, Cynthia Eller, Kimberly C. Duplantier, Mccarthy Peter A, Lawrence M. Zaccaro, F.W. Bangerter, Lee A. Morehouse
Publikováno v:
Journal of Medicinal Chemistry. 40:2547-2554
We have explored the use of steroidal glycosides as cholesterol absorption inhibitors which act through an unknown mechanism. The lead for this program was tigogenin cellobioside (1, tiqueside) which is a weak inhibitor (ED50 = 60 mg/kg) as measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf6347bb2d2ceba68223277c4f5158
https://doi.org/10.1021/jm9702600
https://doi.org/10.1021/jm9702600