Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Eliot M Rosen"'
Publikováno v:
Chinese Journal of Lung Cancer, Vol 15, Iss 7, Pp 391-398 (2012)
Background and objective Indole-3-carbinol (I3C) is a naturally occurring phytochemical found in cruciferous vegetables. The aim of the present study is to investigate the influence of I3C on radiosensitivity in epidermal growth factor receptor (EGFR
Externí odkaz:
https://doaj.org/article/c8256527baa14ce689343b9afc513b90
Autor:
Tejaswita M Karve, Anju Preet, Rosie Sneed, Clara Salamanca, Xin Li, Jingwen Xu, Deepak Kumar, Eliot M Rosen, Tapas Saha
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37697 (2012)
Follistatin (FST), a folliculogenesis regulating protein, is found in relatively high concentrations in female ovarian tissues. FST acts as an antagonist to Activin, which is often elevated in human ovarian carcinoma, and thus may serve as a potentia
Externí odkaz:
https://doaj.org/article/61a5b9fb7f064bd1b014131354aa3cce
Supplementary Figures 1-9 from Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8714deaf03704be66c392acf3f35fc0d
https://doi.org/10.1158/0008-5472.22377666.v1
https://doi.org/10.1158/0008-5472.22377666.v1
Supplementary Figure Legends 1-9 from Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d28d85ffd49da2bff4d2fcb72d7821
https://doi.org/10.1158/0008-5472.22377669
https://doi.org/10.1158/0008-5472.22377669
Autor:
Eliot M. Rosen, Anil K. Jaiswal, Itzhak D. Goldberg, Jingwen Xu, Hyo Jin Kang, Hee Jong Kim, Jeong Keun Rih, Qinghui Meng, Saijun Fan, Insoo Bae
Mutations of the breast cancer susceptibility gene 1 (BRCA1), a tumor suppressor, confer an increased risk for breast, ovarian, and prostate cancers. To investigate the function of the BRCA1 gene, we performed DNA microarray and confirmatory reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47efe2bfdb4461a03bde0e736304d39c
https://doi.org/10.1158/0008-5472.c.6493874.v1
https://doi.org/10.1158/0008-5472.c.6493874.v1
Autor:
Yongxian Ma, York Tomita, Eliseu O. De Oliveira, Robert Clarke, Yumi Ueda, Anju Preet, Li Zhang, Milton L. Brown, Eliot M. Rosen
Publikováno v:
Oncotarget
Previous studies indicate that BRCA1 protein binds to estrogen receptor-alpha (ER) and inhibits its activity. Here, we found that BRCA1 over-expression not only inhibits ER activity in anti-estrogen-resistant LCC9 cells but also partially restores th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18257d45baa35653648f7d78f7fa136c
http://europepmc.org/articles/PMC4747340
http://europepmc.org/articles/PMC4747340
Autor:
Eliot M. Rosen, Shyam Nathan, Milton L. Brown, Eliseu O. De Oliveira, York A. Tomita, Yongxian Ma
We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e5108049e0f3c9d56b15e913222d55
https://europepmc.org/articles/PMC5681404/
https://europepmc.org/articles/PMC5681404/
Autor:
Michael J. Pishvaian, Eliot M. Rosen
Publikováno v:
Current Drug Targets. 15:17-31
The breast cancer susceptibility genes BRCA1 and BRCA2 are classic tumor suppressor genes that exhibit an autosomal dominant pattern of inheritance with high penetrance. BRCA carriers inherit one mutant BRCA allele and one wild-type allele; and the w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2e7a50e68c3348cf98438bba41e006
https://doi.org/10.2174/1389450114666140106095432
https://doi.org/10.2174/1389450114666140106095432
Publikováno v:
Molecular and Clinical Oncology. 1:331-336
Vascular endothelial growth factor (VEGF) is a main angiogenic factor which is known to be upregulated in lung cancer. In the present study, it was demonstrated that sanguinarine, an alkaloid obtained from the bloodroot plant, markedly repressed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf76aa891a0fd2288965c9f7fc40991
https://doi.org/10.3892/mco.2012.41
https://doi.org/10.3892/mco.2012.41