Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.

Autor: Werfel TA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Chemical Engineering, University of Mississippi, Oxford, Mississippi., Hicks DJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Rahman B; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Bendeman WE; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Duvernay MT; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Maeng JG; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Hamm H; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Lavieri RR; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Joly MM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Pulley JM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Elion DL; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Brantley-Sieders DM; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Cook RS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee. rebecca.cook@vanderbilt.edu.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Dec; Vol. 19 (12), pp. 2454-2464. Date of Electronic Publication: 2020 Oct 08.

Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler.

Autor: Woodley CM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Romer AS; Department of Biology, Middle Tennessee State University, Murfreesboro, TN, USA., Wang J; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Guarnaccia AD; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Elion DL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Maxwell JN; Department of Biology, Middle Tennessee State University, Murfreesboro, TN, USA., Guerrazzi K; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., McCann TS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Popay TM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Matlock BK; Vanderbilt University Medical Center Flow Cytometry Shared Resource, Vanderbilt University Medical Center, Nashville, TN, USA., Flaherty DK; Vanderbilt University Medical Center Flow Cytometry Shared Resource, Vanderbilt University Medical Center, Nashville, TN, USA., Lorey SL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Liu Q; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Tansey WP; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA., Weissmiller AM; Department of Biology, Middle Tennessee State University, Murfreesboro, TN, USA. april.weissmiller@mtsu.edu.

Publikováno v: Oncogene [Oncogene] 2021 May; Vol. 40 (20), pp. 3593-3609. Date of Electronic Publication: 2021 Apr 30.

Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers.

Autor: Williams MM; Program in Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA., Elion DL; Program in Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA., Rahman B; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA., Hicks DJ; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA., Sanchez V; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Cook RS; Program in Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37232, USA.; The Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Publikováno v: Oncotarget [Oncotarget] 2019 Oct 09; Vol. 10 (52), pp. 5389-5402. Date of Electronic Publication: 2019 Oct 09 (Print Publication: 2019).

Treatment-Induced Tumor Cell Apoptosis and Secondary Necrosis Drive Tumor Progression in the Residual Tumor Microenvironment through MerTK and IDO1.

Autor: Werfel TA; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Elion DL; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Rahman B; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Hicks DJ; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Sanchez V; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Gonzales-Ericsson PI; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Nixon MJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., James JL; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Balko JM; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Scherle PA; Preclinical Biology, Incyte Corporation, Experimental Station, Wilmington, Delaware., Koblish HK; Preclinical Biology, Incyte Corporation, Experimental Station, Wilmington, Delaware., Cook RS; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee. Rebecca.cook@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee.

Publikováno v: Cancer research [Cancer Res] 2019 Jan 01; Vol. 79 (1), pp. 171-182. Date of Electronic Publication: 2018 Nov 09.

Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations.

Autor: Elion DL; Cancer Biology Program, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Cook RS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: Rebecca.cook@vanderbilt.edu.

Publikováno v: Trends in molecular medicine [Trends Mol Med] 2018 Aug; Vol. 24 (8), pp. 655-656. Date of Electronic Publication: 2018 Jun 28.