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pro vyhledávání: '"Elinor Cleuvers"'
Autor:
Stefan Gründer, Elinor Cleuvers, Michèle Bachmann, Lilia Leisle, Michael A. Margreiter, Audrey Ortega-Ramírez, Giulia Rossetti
Publikováno v:
Journal of medicinal chemistry. 64(18)
Prolonged acidosis, as it occurs during ischemic stroke, induces neuronal death via acid-sensing ion channel 1a (ASIC1a). Concomitantly, it desensitizes ASIC1a, highlighting the pathophysiological significance of modulators of ASIC1a acid sensitivity