Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Elinor, Hortle"'
Autor:
Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that th
Externí odkaz:
https://doaj.org/article/c49c73a4f4614f95ae1cab28b0686048
Autor:
Julia Y. Kam, Elinor Hortle, Elizabeth Krogman, Sherridan E. Warner, Kathryn Wright, Kaiming Luo, Tina Cheng, Pradeep Manuneedhi Cholan, Kazu Kikuchi, James A. Triccas, Warwick J. Britton, Matt D. Johansen, Laurent Kremer, Stefan H. Oehlers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The pathogen Mycobacterium abscessus can switch from a smooth colony form (S) into a highly inflammatory, rough colony form (R) during infection. Here, Kam et al. use an adult zebrafish model of M. abscessus chronic infection to illustrate difference
Externí odkaz:
https://doaj.org/article/21538f5988d2474e8bf1b3bb89145259
Autor:
Chantal Donovan, Richard Y Kim, Izabela Galvao, Andrew G Jarnicki, Alexandra C Brown, Bernadette Jones‐Freeman, Henry M Gomez, Ridhima Wadhwa, Elinor Hortle, Ranjith Jayaraman, Haroon Khan, Sophie Pickles, Priyanka Sahu, Vrushali Chimankar, Xiaofan Tu, Md Khadem Ali, Jemma R Mayall, Duc H Nguyen, Kurtis F Budden, Vinod Kumar, Kate Schroder, Avril AB Robertson, Matthew A Cooper, Peter AB Wark, Brian G Oliver, Jay C Horvat, Philip M Hansbro
Publikováno v:
Immunology & Cell Biology. 100:235-249
Increased inflammasome responses are strongly implicated in inflammatory diseases; however, their specific roles are incompletely understood. Therefore, we sought to examine the roles of nucleotide-binding oligomerization domain-like receptor (NLR) f
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Autor:
Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers
Pathogenic mycobacteria inhibit inflammasome activation to establish infection. Although it is known that potassium efflux is a trigger for inflammasome activation, the interaction between mycobacterial infection, potassium efflux, and inflammasome a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2d21d783a7bf9d3ed4aa37d022a788
https://hdl.handle.net/10453/158662
https://hdl.handle.net/10453/158662
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Uropathogenic Escherichia coli (UPEC) causes urinary tract infections that can result in sepsis. The haemostatic system is protective in the pyelonephritis stage of ascending UPEC infection, but the role of the haemostatic system has not been investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af307f5b7cf11f03399dc7239ce4f955
https://hdl.handle.net/10453/165970
https://hdl.handle.net/10453/165970
Autor:
Paul K. Witting, Amandeep Kaur, Warwick J. Britton, Sonia I. Robertson, Stefan H. Oehlers, Harrison D. Black, Wenbo Xu, Elinor Hortle, Belal Chami, Elizabeth J. New
Publikováno v:
Free Radical Biology and Medicine. 135:157-166
Tuberculosis is a chronic inflammatory disease caused by persistent infection with Mycobacterium tuberculosis. The rise of antibiotic resistant strains necessitates the design of novel treatments. Recent evidence shows that not only is M. tuberculosi
Autor:
Justin J.-L. Wong, Natalia Pinello, Tran Lv, Elinor Hortle, Stefan H. Oehlers, Fontaine Ar, Warwick J. Britton
SummaryPathogenic mycobacteria inhibit inflammasome activation as part of their pathogenesis. While it is known that potassium efflux is a trigger for inflammasome activation, the interaction between mycobacterial infection, potassium efflux and infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8143110d3372d0671815d1484da73a5f
https://doi.org/10.1101/2021.04.21.440692
https://doi.org/10.1101/2021.04.21.440692