Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

Autor: Eline E. van Haaften, Sjeng Quicken, Wouter Huberts, Carlijn V. C. Bouten, Nicholas A. Kurniawan

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

van Haaften et al. show numerical-experimental approach to reconstruct the graft–host response. They interrogate the mechanoregulation in dialysis grafts to solve the disturbed shear stress problem, which can be a cause of neointimal hyperplasia in

Externí odkaz: https://doaj.org/article/5e25773dc2fe4f8d9d8f013fae7a9000

Vascular Mechanobiology: Towards Control of In Situ Regeneration

Autor: Eline E. van Haaften, Carlijn V. C. Bouten, Nicholas A. Kurniawan

Publikováno v: Cells, Vol 6, Iss 3, p 19 (2017)

The paradigm of regenerative medicine has recently shifted from in vitro to in situ tissue engineering: implanting a cell-free, biodegradable, off-the-shelf available scaffold and inducing the development of functional tissue by utilizing the regener

Externí odkaz: https://doaj.org/article/f092dccf724b48b6a8093752b7f7d4df

Impact of Additives on Mechanical Properties of Supramolecular Electrospun Scaffolds

Autor: Carlijn V. C. Bouten, Bastiaan D. Ippel, Eline E. van Haaften, Patricia Y. W. Dankers

Publikováno v: ACS Applied Polymer Materials, 2(9), 3742-3748. American Chemical Society
ACS Applied Polymer Materials

The mechanical properties of scaffolds used for mechanically challenging applications such as cardiovascular implants are unequivocally important. Here, the effect of supramolecular additive functionalization on mechanical behavior of electrospun sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0955b188242dc20b24f8472e0f0ec3
https://research.tue.nl/en/publications/e3b1686d-868c-4b49-ad82-c19ec5252d67

Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

Autor: Carlijn V. C. Bouten, Wouter Huberts, Eline E. van Haaften, Sjeng Quicken, Nicholas A. Kurniawan

Publikováno v: Communications Biology
Communications Biology, 4(1):546. Nature Publishing Group
Communications biology, 4(1):546. Springer Nature
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Disturbed shear stress is thought to be the driving factor of neointimal hyperplasia in blood vessels and grafts, for example in hemodialysis conduits. Despite the common occurrence of neointimal hyperplasia, however, the mechanistic role of shear st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e909eff65c1b30aede3fc40ead9033
http://europepmc.org/articles/PMC8110791

Decoupling the effect of shear stress and stretch on tissue growth and remodeling in a vascular graft

Autor: Jurgen A Bulsink, Anthal I.P.M. Smits, Marcel C. M. Rutten, Nicholas A. Kurniawan, Mathieu A.J. van Kelle, Eline E. van Haaften, Carlijn V. C. Bouten, Tamar B Wissing, Kujtim Gashi

Publikováno v: Tissue Engineering. Part C: Methods, 24(7), 418-429. Mary Ann Liebert Inc.

The success of cardiovascular tissue engineering (TE) strategies largely depends on the mechanical environment in which cells develop a neotissue through growth and remodeling processes. This mechanical environment is defined by the local scaffold ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64925cc7a71c326559ef437319a2a00
http://www.scopus.com/inward/record.url?scp=85050013488&partnerID=8YFLogxK