AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model

Autor: Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts‐Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra I Duqué, Cécile Vincke, Yona Levites, Todd E Golde, Takaomi C Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G Holt

Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 4, Pp 1-21 (2022)

Abstract Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous syst

Externí odkaz: https://doaj.org/article/10d3c6ff5fb2440ca2d3a9bf9989e4aa

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Autor: Jef Swerts, Valerie Uytterhoeven, Nuno Apóstolo, Patrik Verstreken, Zsuzsanna Callaerts-Vegh, Pablo Largo-Barrientos, Keimpe D. Wierda, Bart De Strooper, Tara L. Spires-Jones, Caitlin Davies, Eline Creemers, Joris de Wit, Joseph McInnes

Publikováno v: Largo-Barrientos, P, Apostolo, N, Creemers, E, Callaerts-Vegh, Z, Swerts, J, Davies, C, McInnes, J, Wierda, K, De Strooper, B, Spires-Jones, T, de Wit, J, Uytterhoeven, V & Verstreken, P 2021, ' Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation ', Neuron, vol. N/A, pp. 1-11.e1-e5 . https://doi.org/10.1016/j.neuron.2020.12.016
Neuron

Tau is a major driver of neurodegeneration and is implicated in over 20 diseases. Tauopathies are characterized by synaptic loss and neuroinflammation, but it is unclear if these pathological events are causally linked. Tau binds to Synaptogyrin-3 on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac16a252e265e0580a33addcb866c78
https://www.pure.ed.ac.uk/ws/files/188885541/largo_barrientos.pdf

Hypercholesterolemia in young adult APOE−/− mice alters epidermal lipid composition and impairs barrier function

Autor: Eline Creemers, Menno Hoekstra, Gert S. Gooris, Renata Martins Cardoso, Miranda Van Eck, Samira Absalah, Joke A. Bouwstra

Publikováno v: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1864(7), 976-984

Long-term exposure to hypercholesterolemia induces the development of skin xanthoma's characterized by the accumulation of lipid-laden foam cells in humans and in mice. Early skin changes in response to hypercholesterolemia are however unknown. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6302315432675ebb4f9b98dda67b21a2
https://hdl.handle.net/1887/77725

Secreted amyloid-β precursor protein functions as a GABA

Autor: Heather C, Rice, Daniel, de Malmazet, An, Schreurs, Samuel, Frere, Inge, Van Molle, Alexander N, Volkov, Eline, Creemers, Irena, Vertkin, Julie, Nys, Fanomezana M, Ranaivoson, Davide, Comoletti, Jeffrey N, Savas, Han, Remaut, Detlef, Balschun, Keimpe D, Wierda, Inna, Slutsky, Karl, Farrow, Bart, De Strooper, Joris, de Wit

Publikováno v: Science (New York, N.Y.). 363(6423)

Amyloid-β precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating evidence suggests that APP has a synaptic function mediated by an unidentified receptor for secr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a62010093beb8c535651e6903a9c70a7
https://pubmed.ncbi.nlm.nih.gov/30790537