Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Elina Pathak"'
Autor:
Jieqiong Zhang, Zhenhua Hu, Hwa Hwa Chung, Yun Tian, Kah Weng Lau, Zheng Ser, Yan Ting Lim, Radoslaw M. Sobota, Hwei Fen Leong, Benjamin Jieming Chen, Clarisse Jingyi Yeo, Shawn Ying Xuan Tan, Jian Kang, Dennis Eng Kiat Tan, Ieng Fong Sou, Urszula Lucja McClurg, Manikandan Lakshmanan, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Esther Sook Miin Wong, Vinay Tergaonkar, Ravisankar Rajarethinam, Elina Pathak, Wai Leong Tam, Ern Yu Tan, Wee-Wei Tee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits bre
Externí odkaz:
https://doaj.org/article/cb2e731233234766a276c66996f09b7a
Autor:
Frances Karla Kusuma, Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmed, Pushkar Dakle, Wai Khang Yong, Elina Pathak, Vikas Madan, Yan Yi Jiang, Wai Leong Tam, Dennis Kappei, Peter Dröge, H. Phillip Koeffler, Maya Jeitany
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The kinase inhibitor Ponatinib inhibits an ABL1-JUN signalling axis and alters telomere homeostasis, reduces telomere synthesis, and provokes telomere dysfunction in cancer cells which employ the alternative lengthening of telomeres mechanisms.
Externí odkaz:
https://doaj.org/article/bc2741f3057b451aadd3c9a301ac079d
Autor:
Jing Lin, Jia Hui Jane Lee, Kathirvel Paramasivam, Elina Pathak, Zhenxun Wang, Zacharias Aloysius Dwi Pramono, Bing Lim, Keng Boon Wee, Uttam Surana
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 263-273 (2017)
Self-renewing tumor-initiating cells (TICs) are thought to be responsible for tumor recurrence and chemo-resistance. Glycine decarboxylase, encoded by the GLDC gene, is reported to be overexpressed in TIC-enriched primary non-small-cell lung carcinom
Externí odkaz:
https://doaj.org/article/14979fe742534762afeed8b2e3cefe64
Autor:
Dennis Kappei, Aishvaryaa Prabhu, Vineeth T. Mukundan, Vikas Madan, Pushkar Dakle, Maya Jeitany, Yan-Yi Jiang, Elina Pathak, H. Phillip Koeffler, Deepika Kanojia, Yosef Landesman, Wai Leong Tam
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 78, iss 4
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences
Proteasome inhibitors, such as bortezomib and carfilzomib, have shown efficacy in anti-cancer therapy in hematological diseases but not in solid cancers. Here, we found that liposarcomas (LPS) are susceptible to proteasome inhibition, and identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7553d35f00b8dce203b8533f611be40
https://doi.org/10.1007/s00018-020-03620-w
https://doi.org/10.1007/s00018-020-03620-w
Autor:
May Yin Lee, S. Shatishwaran, Roger Foo, Magendran Muniandy, Benita Tan, Joanna Zhen Zhen Yeo, Soo-Chin Lee, Chow Yin Wong, Elina Pathak, Preetha Madhukumar, Li Ping Toh, William Haowei Xie, Wai Leong Tam, Esther Kai Lay Peh, Ju Yuan, Yirong Sim, Veronique Kiak Mien Tan, Lih-Wen Deng, Wilson Wei Sheng Tan, Yin Ying Ho, Elaine Hsuen Lim, Rebecca Dent, Markus R. Wenk, Puay Hoon Tan, Ying Swan Ho, Jack Chan, Siming Ma, Federico Torta, Ser Yue Loo, Yoon Sim Yap, Tira Jing Ying Tan, Wei Sean Yong, Kong Wee Ong
Publikováno v:
Science Advances
Description
Fatty acid oxidation is a metabolic gateway that regulates cellular plasticity and supports metastasis in breast cancer.
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transitio
Fatty acid oxidation is a metabolic gateway that regulates cellular plasticity and supports metastasis in breast cancer.
Cell state transitions control the functional behavior of cancer cells. Epithelial-to-mesenchymal transitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e6a08d9c6618541c5462a65d49345a
https://hdl.handle.net/10356/154360
https://hdl.handle.net/10356/154360
Autor:
Jia Hui Jane Lee, Kathirvel Paramasivam, Elina Pathak, Bing Lim, Keng Boon Wee, Jing Lin, Zacharias A.D. Pramono, Uttam Surana, Zhenxun Wang
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 263-273 (2017)
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 263-273 (2017)
Self-renewing tumor-initiating cells (TICs) are thought to be responsible for tumor recurrence and chemo-resistance. Glycine decarboxylase, encoded by the GLDC gene, is reported to be overexpressed in TIC-enriched primary non-small-cell lung carcinom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0bf467dd0a6756e5cf513dbd9b9d3d
https://pubmed.ncbi.nlm.nih.gov/29246305
https://pubmed.ncbi.nlm.nih.gov/29246305
Autor:
Joseph H. Holthoff, Horace J. Spencer, Elina Pathak, Zhen Wang, Neriman Gokden, Philip R. Mayeux, Kathryn A. Seely
Publikováno v:
The American Journal of Pathology. 180(2):505-516
Acute kidney injury is a frequent and serious complication of sepsis. To better understand the development of sepsis-induced acute kidney injury, we performed the first time-dependent studies to document changes in renal hemodynamics and oxidant gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ea90576dec5ebd9f43173fcd8e1f82
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 340:192-201
Oxidative stress has been implicated to play a major role in multiorgan dysfunction during sepsis. To study the mechanism of oxidant generation in acute kidney injury (AKI) during sepsis, we developed an in vitro model of sepsis using primary culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801fa7193c6301b5e34f75fd731ec2c4
https://doi.org/10.1124/jpet.111.183756
https://doi.org/10.1124/jpet.111.183756
Autor:
Ju Yuan, Elina Pathak, Siming Ma, Roger Foo, Yirong Sim, Preetha Madhukumar, Elaine Lim, Wai Leong Tam, Markus R. Wenk, Jack Chan, Kong Wee Ong, Chow Yin Wong, Benita Tan, Wilson Lek Wen Tan, Giridharan Periyasamy, Liping Toh, Veronique Kiak Mien Tan, Federico Torta, Ser Yue Loo, Yoon Sim Yap, Tira Jing Ying Tan, Wei Sean Yong
Publikováno v:
Molecular Cancer Research. 16:B22-B22
Triple-negative breast cancer (TNBC), as immunohistochemically defined by its estrogen receptor (ER)-negative, progesterone receptor (PR)-negative and human epidermal growth factor receptor-2 (HER2)-negative status, is an important subtype due to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b35397c8f81837862a9e7a0aaf1f05
https://doi.org/10.1158/1557-3125.advbc17-b22
https://doi.org/10.1158/1557-3125.advbc17-b22
Autor:
Philip R. Mayeux, Elina Pathak
Publikováno v:
Toxicological Sciences. 115:475-481
Sepsis-induced acute kidney injury (AKI) is a complex disease characterized by generation of inducible nitric oxide synthase (iNOS)-derived reactive nitrogen species (RNS) by the renal tubular epithelium. While most in vitro models of sepsis use comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56317101ec90a59a1f1749b4a920ca3
https://doi.org/10.1093/toxsci/kfq058
https://doi.org/10.1093/toxsci/kfq058