IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence.

Autor: Ellen J Wehrens, Kurt A Wong, Ankan Gupta, Ayesha Khan, Chris A Benedict, Elina I Zuniga

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0201249 (2018)

The role of IL-27 in antiviral immunity is still incompletely understood, especially in the context of chronic viruses that induce a unique environment in their infected host. Cytomegalovirus (CMV) establishes a persistent, tissue localized infection

Externí odkaz: https://doaj.org/article/d8da03e7e8734d7987c2c0f4beff227f

Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infection

Autor: Carolina Chiale, Trever T. Greene, Elina I. Zuniga

Publikováno v: Immunological reviews. 309(1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has caused millions of deaths in the past two years. Although initially little was understood about this virus, recent research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b0c3830dc5d5b2ba1594f50a213203
https://pubmed.ncbi.nlm.nih.gov/35775361

Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting

Autor: Roland El Ghazal, So Young Kim, Scott C. Johns, Purva Gupta, Mark M. Fuster, Elina I. Zuniga

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 86-97 (2020)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.), vol 22, iss 2

While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other tumors, anti-tumor immunity is suppressed; and while some recent therapies boost T-cell mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7e0acb8a762ad1ad8ad75a631c6062
http://www.sciencedirect.com/science/article/pii/S1476558619303045

Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response

Autor: Melisa Gorosito Serrán, Facundo Fiocca Vernengo, Laura Almada, Cristian G. Beccaria, Yamila Gazzoni, Pablo F. Canete, Jonathan A. Roco, Jimena Tosello Boari, Maria Cecilia Ramello, Ellen Wehrens, Yeping Cai, Elina I. Zuniga, Carolina L. Montes, Ian A. Cockburn, Eva V. Acosta Rodriguez, Carola G. Vinuesa, Adriana Gruppi

Publikováno v: Frontiers in immunology. 13

During infections with protozoan parasites or some viruses, T cell immunosuppression is generated simultaneously with a high B cell activation. It has been described that, as well as producing antibodies, plasmablasts, the differentiation product of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e6a40ecd2c1421852e92c17229cf20
https://pubmed.ncbi.nlm.nih.gov/35651611

Group A Streptococcal S Protein Utilizes Red Blood Cells as Immune Camouflage and Is a Critical Determinant for Immune Evasion

Autor: Kit Pogliano, Man Ying, Xiaoli Wei, David Gonzalez, Liangfang Zhang, Ronnie H. Fang, Maya Holay, Trever T Greene, Diana Dehaini, Jenna S. Sands, Igor H. Wierzbicki, Christopher N. LaRock, Anaamika Campeau, Anne Lamsa, Elina I. Zuniga

Publikováno v: Cell Reports, Vol 29, Iss 10, Pp 2979-2989.e15 (2019)
Cell reports
Cell reports, vol 29, iss 10

SUMMARY Group A Streptococcus (GAS) is a human-specific pathogen that evades the host immune response through the elaboration of multiple virulence factors. Although many of these factors have been studied, numerous proteins encoded by the GAS genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3127f9f92ab741b1b4e2ff27f57f2daf
http://www.sciencedirect.com/science/article/pii/S221112471931472X