Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elina Ekokoski"'
Autor:
Milla Summanen, Niko Granqvist, Raimo K Tuominen, Marjo Yliperttula, C Theo Verrips, Johannes Boonstra, Christophe Blanchetot, Elina Ekokoski
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35630 (2012)
Dysregulation of PKCε is involved in several serious diseases such as cancer, type II diabetes and Alzheimer's disease. Therefore, specific activators and inhibitors of PKCε hold promise as future therapeutics, in addition to being useful in resear
Externí odkaz:
https://doaj.org/article/9b60389161564e70bffc909754728330
Publikováno v:
PLoS ONE, Vol 6, Iss 6 (2011)
Externí odkaz:
https://doaj.org/article/e41a481fc557426d9181fc2460a2043a
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20053 (2011)
Diacylglycerol (DAG)-mediated signaling pathways, such as those mediated by protein kinase C (PKC), are central in regulating cell proliferation and apoptosis. DAG-responsive C1 domains are therefore considered attractive drug targets. Our group has
Externí odkaz:
https://doaj.org/article/e3685c5f959d4ba7b7a7922827e33017
Autor:
Marja Ahti, Gergana Gateva, Virpi Talman, Raimo K. Tuominen, Pekka Lappalainen, Elina Ekokoski
Publikováno v:
European Journal of Pharmaceutical Sciences. 55:46-57
Diacylglycerol (DAG) is a central mediator of signaling pathways that regulate cell proliferation, survival and apoptosis. Therefore, C1 domain, the DAG binding site within protein kinase C (PKC) and other DAG effector proteins, is considered a poten
Autor:
Gustav Boije af Gennäs, Salla Sorvari, Marialaura Amadio, Virpi Talman, Raimo K. Tuominen, Stefano Govoni, Elina Ekokoski, Cecilia Osera, Jari Yli-Kauhaluoma, Alessia Pascale, Daniela Rossi, Simona Collina
Publikováno v:
Pharmacological Research. 73:44-54
Protein kinase C (PKC) is a family of serine/threonine phosphotransferases ubiquitously expressed and involved in multiple cellular functions, such as proliferation, apoptosis and differentiation. The C1 domain of PKC represents an attractive drug ta
Autor:
Virpi Talman, Heinrich Lang, Jari Yli-Kauhaluoma, Irene Kylänlahti, Raimo K. Tuominen, Henri Xhaard, Elina Ekokoski, Timo Ruotsalainen, Gustav Boije af Gennäs, Tobias Rüffer, Gloria Wissel, Alexandros Kiriazis
Publikováno v:
Tetrahedron. 67:8665-8670
Protein kinase C (PKC) is a widely studied molecular target for the treatment of cancer and other diseases. We have approached the issue of modifying PKC function by targeting the C1 domain in the regulatory region of the enzyme. By using the X-ray c
Publikováno v:
Cellular Signalling. 18:1671-1678
Several sphingolipid derivatives, including sphingosylphosphorylcholine (SPC), regulate a multitude of biological processes. In the present study we show that both human thyroid cancer cells (FRO cells) and normal human thyroid cells express G protei
Autor:
Raimo K. Tuominen, Kid Törnquist, Elina Ekokoski, Cia Ramström, Michael Pasternack, Hugh Chapman
Publikováno v:
Cellular Signalling. 16:1417-1424
Tumor necrosis factor alpha (TNFalpha) alters the electrophysiological properties of many cell types. In thyroid cells however, the effects have not yet been elucidated. Here, we report the effect of TNFalpha and its second messenger ceramide on the
Autor:
Arturo Garcia-Horsman, Moshe Finel, Päivi Tammela, Pia Vuorela, Raimo K. Tuominen, Elina Ekokoski, Virpi Talman
Publikováno v:
Drug Development Research. 63:76-87
Protein kinase C (PKC) isozymes are important signal transducers in a number of cellular responses that makes PKC inhibition a topical target for drug discovery. In this study, a set of natural compounds and their derivatives (43 in total) were scree
Publikováno v:
Journal of Cellular Physiology. 187:166-175
The expression of the P2 receptors and their functional responses were studied in rat thyroid FRTL-5 cells. RT-PCR analysis revealed transcripts for the G protein-coupled P2Y(2), P2Y(4) and P2Y(6) receptors, and for the transmitter-gated ion channel