Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Elina, Ikonen"'
Autor:
Vesa M. Olkkonen, Elina Ikonen
Publikováno v:
Contact, Vol 7 (2024)
This review discusses how research around the oxysterol-binding protein family has evolved. We briefly summarize how this protein family, designated OSBP-related (ORP) or OSBP-like (OSBPL) proteins, was discovered, how protein domains highly conserve
Externí odkaz:
https://doaj.org/article/244e0d6367a847079bcd0ca63f7517d3
Autor:
Shiqian Li, Yafei Wang, Miesje van der Stoel, Xin Zhou, Shrinidhi Madhusudan, Kristiina Kanerva, Van Dien Nguyen, Nazli Eskici, Vesa M. Olkkonen, You Zhou, Taneli Raivio, Elina Ikonen
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Recent developments in auxin-inducible degron (AID) technology have increased its popularity for chemogenetic control of proteolysis. However, generation of human AID cell lines is challenging, especially in human embryonic stem cells (hESCs
Externí odkaz:
https://doaj.org/article/b386292dc07c45e88b124344bcaa5ff8
Autor:
Viola Nähse, Camilla Raiborg, Kia Wee Tan, Sissel Mørk, Maria Lyngaas Torgersen, Eva Maria Wenzel, Mireia Nager, Veijo T. Salo, Terje Johansen, Elina Ikonen, Kay Oliver Schink, Harald Stenmark
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic r
Externí odkaz:
https://doaj.org/article/4b4cc69eb99844d38600776ee09b1dd5
Autor:
Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T. Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Dumesnil et al. report that cholesterol esters (CE), which only melt above body temperature, form supercooled liquid crystalline lipid droplets (LD). Triacylglycerols (TG) solubilize CE to help CE LD nucleation. Through clustering TGs in the ER membr
Externí odkaz:
https://doaj.org/article/1cacaf49d32d4b7a9a98a9bcd3cf7d33
Autor:
Abel Szkalisity, Filippo Piccinini, Attila Beleon, Tamas Balassa, Istvan Gergely Varga, Ede Migh, Csaba Molnar, Lassi Paavolainen, Sanna Timonen, Indranil Banerjee, Elina Ikonen, Yohei Yamauchi, Istvan Ando, Jaakko Peltonen, Vilja Pietiäinen, Viktor Honti, Peter Horvath
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
High-content screening prompted the development of software enabling discrete phenotypic analysis of single cells. Here, the authors show that supervised continuous machine learning can drive novel discoveries in diverse imaging experiments and prese
Externí odkaz:
https://doaj.org/article/f49f0d2d8b5f4b588375e657d0654bfa
Autor:
Behnam Lak, Shiqian Li, Ilya Belevich, Sreesha Sree, Rebeka Butkovic, Elina Ikonen, Eija Jokitalo
Publikováno v:
European Journal of Cell Biology, Vol 100, Iss 7, Pp 151180- (2021)
The endoplasmic reticulum (ER) is a large, single-copy, membrane-bound organelle that comprises an elaborate 3D network of diverse structural subdomains, including highly curved tubules, flat sheets, and parts that form contacts with nearly every oth
Externí odkaz:
https://doaj.org/article/59605b77052f4a69b057ac9413f3faa3
Autor:
Burcin Gungor, Lauri Vanharanta, Maarit Hölttä-Vuori, Juho Pirhonen, Nikolaj H.T. Petersen, Silvia Gramolelli, Päivi M. Ojala, Thomas Kirkegaard, Elina Ikonen
Publikováno v:
Molecular Metabolism, Vol 28, Iss , Pp 135-143 (2019)
Objective: Heat Shock Proteins (HSPs) maintain cellular homeostasis under stress. HSP70 represents a major stress-inducible family member and has been identified as a druggable target in inherited cholesterol-sphingolipid storage diseases. We investi
Externí odkaz:
https://doaj.org/article/2ed7880320f64daea1d5fa9a9ec7e58a
Autor:
Saskia Heybrock, Kristiina Kanerva, Ying Meng, Chris Ing, Anna Liang, Zi-Jian Xiong, Xialian Weng, Young Ah Kim, Richard Collins, William Trimble, Régis Pomès, Gilbert G. Privé, Wim Annaert, Michael Schwake, Joerg Heeren, Renate Lüllmann-Rauch, Sergio Grinstein, Elina Ikonen, Paul Saftig, Dante Neculai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.
Externí odkaz:
https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd
Autor:
Xavier Prasanna, Veijo T Salo, Shiqian Li, Katharina Ven, Helena Vihinen, Eija Jokitalo, Ilpo Vattulainen, Elina Ikonen
Publikováno v:
PLoS Biology, Vol 19, Iss 1, p e3000998 (2021)
Seipin is a disk-like oligomeric endoplasmic reticulum (ER) protein important for lipid droplet (LD) biogenesis and triacylglycerol (TAG) delivery to growing LDs. Here we show through biomolecular simulations bridged to experiments that seipin can tr
Externí odkaz:
https://doaj.org/article/c8f7f019484345a49fecb9938555c2ef
Publikováno v:
Contact, Vol 3 (2020)
Lipid droplets (LDs) are dynamic cellular hubs of lipid metabolism. While LDs contact a plethora of organelles, they have the most intimate relationship with the endoplasmic reticulum (ER). Indeed, LDs are initially assembled at specialized ER subdom
Externí odkaz:
https://doaj.org/article/5528f8e4d29b46eb8fd7a2add66eab3d