Convolutional Neural Networks Enable Robust Automatic Segmentation of the Rat Hippocampus in MRI After Traumatic Brain Injury

Autor: Riccardo De Feo, Elina Hämäläinen, Eppu Manninen, Riikka Immonen, Juan Miguel Valverde, Xavier Ekolle Ndode-Ekane, Olli Gröhn, Asla Pitkänen, Jussi Tohka

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

Registration-based methods are commonly used in the automatic segmentation of magnetic resonance (MR) brain images. However, these methods are not robust to the presence of gross pathologies that can alter the brain anatomy and affect the alignment o

Externí odkaz: https://doaj.org/article/c850e16bb8b54a38ab7a0292a30b4aec

MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post−Traumatic Epilepsy—Challenges and Gains

Autor: Xavier Ekolle Ndode-Ekane, Riikka Immonen, Elina Hämäläinen, Eppu Manninen, Pedro Andrade, Robert Ciszek, Tomi Paananen, Olli Gröhn, Asla Pitkänen

Publikováno v: Biomedicines, Vol 10, Iss 9, p 2295 (2022)

Brain atrophy induced by traumatic brain injury (TBI) progresses in parallel with epileptogenesis over time, and thus accurate placement of intracerebral electrodes to monitor seizure initiation and spread at the chronic postinjury phase is challengi

Externí odkaz: https://doaj.org/article/91d84f0b118949bdb0f83b57d7cff234

Acute Hippocampal Damage as a Prognostic Biomarker for Cognitive Decline but Not for Epileptogenesis after Experimental Traumatic Brain Injury

Autor: Pitkänen, Eppu Manninen, Karthik Chary, Riccardo De Feo, Elina Hämäläinen, Pedro Andrade, Tomi Paananen, Alejandra Sierra, Jussi Tohka, Olli Gröhn, Asla

Publikováno v: Biomedicines; Volume 10; Issue 11; Pages: 2721

It is necessary to develop reliable biomarkers for epileptogenesis and cognitive impairment after traumatic brain injury when searching for novel antiepileptogenic and cognition-enhancing treatments. We hypothesized that a multiparametric magnetic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::1e12d06a0f0b3d9a0580270eb7830d49

Acute hippocampal damage as a prognostic biomarker for cognitive decline but not for epileptogenesis after experimental traumatic brain injury

Autor: Eppu, Manninen, Karthik, Chary, Riccardo, De Feo, Elina, Hämäläinen, Pedro, Andrade, Tomi, Paananen, Alejandra, Sierra, Jussi, Tohka, Olli, Gröhn, Asla, Pitkänen

It is necessary to develop reliable biomarkers for epileptogenesis and cognitive impairment after traumatic brain injury when searching for novel antiepileptogenic and cognition-enhancing treatments. We hypothesized that a multiparametric magnetic re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::259273eb07d3bd71dbbe4f7d6b318e06
https://hdl.handle.net/11573/1670674

Targeting Oxidative Stress with Antioxidant Duotherapy after Experimental Traumatic Brain Injury

Autor: Jenni, Kyyriäinen, Natallie, Kajevu, Ivette, Bañuelos, Leonardo, Lara, Anssi, Lipponen, Silvia, Balosso, Elina, Hämäläinen, Shalini, Das Gupta, Noora, Puhakka, Teemu, Natunen, Teresa, Ravizza, Annamaria, Vezzani, Mikko, Hiltunen, Asla, Pitkänen

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10555, p 10555 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug N-acetylcysteine (NAC) or sulforaphane (SFN) as monotherapies or duotherapy in vitro in neuron-BV2 microglial co-cultures and validated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6435ead3cc31fc05aac0e1276438e929
https://www.mdpi.com/1422-0067/22/19/10555