Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Elin S. Gray"'
Autor:
Jin-Soo Kim, Dennis R. Taaffe, Daniel A. Galvão, Timothy D. Clay, Andrew D. Redfern, Elin S. Gray, Robert U. Newton
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Introduction Physical activity is associated with improved disease progression and cancer-specific survival in patients with prostate cancer (PCa). However, the mechanisms underlying these associations remain unclear, while the relative impa
Externí odkaz:
https://doaj.org/article/6526fa2a1d1f48f19bb60a8a65bf2bbd
Autor:
Elena Denisenko, Leanne de Kock, Adeline Tan, Aaron B. Beasley, Maria Beilin, Matthew E. Jones, Rui Hou, Dáithí Ó Muirí, Sanela Bilic, G. Raj K. A. Mohan, Stuart Salfinger, Simon Fox, Khaing P. W. Hmon, Yen Yeow, Youngmi Kim, Rhea John, Tami S. Gilderman, Emily Killingbeck, Elin S. Gray, Paul A. Cohen, Yu Yu, Alistair R. R. Forrest
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract High-grade serous ovarian carcinoma (HGSOC) is genetically unstable and characterised by the presence of subclones with distinct genotypes. Intratumoural heterogeneity is linked to recurrence, chemotherapy resistance, and poor prognosis. Her
Externí odkaz:
https://doaj.org/article/e74fdf5a18e94838a46beb1421419119
Autor:
Brendan J. Crosby, Robert U. Newton, Daniel A. Galvão, Dennis R. Taaffe, Pedro Lopez, Tarek M. Meniawy, Muhammad A. Khattak, Wei‐Sen Lam, Elin S. Gray, Favil Singh
Publikováno v:
Cancer Medicine, Vol 12, Iss 13, Pp 14694-14706 (2023)
Abstract Purpose To determine the feasibility, safety and preliminary efficacy of a telehealth supervised exercise programme in patients with advanced melanoma receiving checkpoint inhibitor therapy. Methods A 8‐week non‐randomised feasibility pi
Externí odkaz:
https://doaj.org/article/49605488641649d1bf952aa39fa47199
Autor:
Du-Bois Asante, Ganendra R. K. A. Mohan, Emmanuel Acheampong, Melanie Ziman, Leslie Calapre, Tarek M. Meniawy, Elin S. Gray, Aaron B. Beasley
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Circulating tumour cells (CTCs) are heterogenous and contain genetic information from the tumour of origin. They bear specific intra- and extra-cellular protein markers aiding in their detection. However, since these markers may be shared wi
Externí odkaz:
https://doaj.org/article/81216f2939a1476ea52d02ede55fda82
Autor:
Leslie Calapre, Tindaro Giardina, Aaron B. Beasley, Anna L. Reid, Colin Stewart, Benhur Amanuel, Tarek M. Meniawy, Elin S. Gray
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Plasma circulating tumour DNA (ctDNA) has been suggested to be a viable biomarker of response to treatment in patients with high grade serous ovarian carcinoma (HGSOC). TP53 mutations are present in more than 90% of HGSOCs but somatic varian
Externí odkaz:
https://doaj.org/article/4563136ea8714a7294842de73f101b88
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 691-704 (2021)
The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is known about its structure and drug-binding sites. In this study, we
Externí odkaz:
https://doaj.org/article/2fc1352c0ec24d699769e56989ee6736
Autor:
Peter A. Johansson, Kelly Brooks, Felicity Newell, Jane M. Palmer, James S. Wilmott, Antonia L. Pritchard, Natasa Broit, Scott Wood, Matteo S. Carlino, Conrad Leonard, Lambros T. Koufariotis, Vaishnavi Nathan, Aaron B. Beasley, Madeleine Howlie, Rebecca Dawson, Helen Rizos, Chris W. Schmidt, Georgina V. Long, Hayley Hamilton, Jens F. Kiilgaard, Timothy Isaacs, Elin S. Gray, Olivia J. Rolfe, John J. Park, Andrew Stark, Graham J. Mann, Richard A. Scolyer, John V. Pearson, Nicolas van Baren, Nicola Waddell, Karin W. Wadt, Lindsay A. McGrath, Sunil K. Warrier, William Glasson, Nicholas K. Hayward
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Uveal melanoma has a propensity to metastasise. Here, the authors report the whole genome sequence of 103 uveal melanomas and find that the tumour mutational burden is variable and that two subsets of tumours are characterised by MBD4 mutations and a
Externí odkaz:
https://doaj.org/article/58e3d3d357e64515ab52e5174e676c01
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-5 (2019)
Abstract Background Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. The presence of ctDNA in the blood is a result of biological processes, namely tumour
Externí odkaz:
https://doaj.org/article/433a27cffbff4fd893b486a62b330e15
Autor:
Brendan J. Crosby BSc, Pedro Lopez MSc, Daniel A. Galvão PhD, Robert U. Newton PhD, DSc, Dennis R. Taaffe PhD, DSc, MPH, Tarek M. Meniawy MBBS, PhD, Lydia Warburton MBBS, Muhammad A. Khattak MBBS, Elin S. Gray PhD, Favil Singh PhD
Publikováno v:
Integrative Cancer Therapies, Vol 20 (2021)
Purpose: Although exercise medicine is recommended to counter treatment-related side-effects and improve health-related outcomes of patients affected by different cancers, no specific recommendations exist for patients with melanoma. As a result, we
Externí odkaz:
https://doaj.org/article/93f3a1cdd741487f932bf059f519d164
Autor:
Leslie Calapre, Tindaro Giardina, Cleo Robinson, Anna L. Reid, Zeyad Al‐Ogaili, Michelle R. Pereira, Ashleigh C. McEvoy, Lydia Warburton, Nicholas K. Hayward, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Benhur Amanuel, Melanie Ziman, Elin S. Gray
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 171-184 (2019)
Circulating tumor DNA (ctDNA) may serve as a surrogate to tissue biopsy for noninvasive identification of mutations across multiple genetic loci and for disease monitoring in melanoma. In this study, we compared the mutation profiles of tumor biopsie
Externí odkaz:
https://doaj.org/article/98c3acf65a924037b07e2a94d106762e