Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elin Rodger"'
Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist
Autor:
Scott Cooper, Gary Calandra, Brent L. Wood, Ron MacFarland, Hal E. Broxmeyer, W. Conrad Liles, Gary Bridger, Elin Rodger, Kai Hübel, David C. Dale, Giao Hangoc, Geoffrey W. Henson
Publikováno v:
Supportive Cancer Therapy. 1:165-172
Stromal cell-derived factor-1 (SDF-1/CXCL12) plays a key regulatory role in the trafficking of hematopoietic cells. AMD3100 is a specific antagonist of the binding of SDF-1 to its receptor, CXCR4. This phase I study assessed the hematological effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7050280472c256c8990fb58c5296b87b
https://doi.org/10.3816/sct.2004.n.008
https://doi.org/10.3816/sct.2004.n.008
Autor:
Cornelia Zeidler, Philip S. Rosenberg, Laurence A. Boxer, David C. Dale, Peter E. Newburger, Mary Ann Bonilla, Bin Zhu, Daniel C. Link, Vahagn Makaryan, Elin Rodger, Karl Welte, Akiko Shimamura, Julia Skokowa, Audrey Anna Bolyard, Merideth L. Kelley
Publikováno v:
Current opinion in hematology. 22(1)
Mutations in the gene for neutrophil elastase, ELANE, cause cyclic neutropenia (CyN) and severe congenital neutropenia (SCN). This study summarized data from the Severe Chronic Neutropenia International Registry (SCNIR) on genotype-phenotype relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57500a3d401e1e0ace784d91f099d557
https://pubmed.ncbi.nlm.nih.gov/25427142
https://pubmed.ncbi.nlm.nih.gov/25427142
Autor:
David C. Dale, Elin Rodger, Emil Y. Chi, Mechthild Jonas, W. Conrad Liles, Andrew A.G. Aprikyan
Publikováno v:
Blood. 97:147-153
Cyclic neutropenia (CN) is a congenital hematopoietic disorder characterized by remarkably regular oscillations of blood neutrophils from near normal to extremely low levels at 21-day intervals. Recurring episodes of severe neutropenia lead to repeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529e2db63f8ca566c4a530eeff2c102a
https://doi.org/10.1182/blood.v97.1.147
https://doi.org/10.1182/blood.v97.1.147
Publikováno v:
Blood. 85:74-79
Grey collie dogs have cyclic fluctuations in their blood cell counts caused by a regulatory defect of hematopoietic stem cells. To examine the role of stem cell factor (SCF) or its receptor in this disorder, we investigated the stimulatory effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c29131d82ae8550938db5711372df74
https://doi.org/10.1182/blood.v85.1.74.bloodjournal85174
https://doi.org/10.1182/blood.v85.1.74.bloodjournal85174
Autor:
Hal E. Broxmeyer, Scott Cooper, David C. Dale, Geoffrey W. Henson, Elin Rodger, Gary Calandra, W. Conrad Liles, Gary Bridger, Kai Hübel, Brent L. Wood, Giao Hangoc
Publikováno v:
Blood. 102:2728-2730
Stromal cell-derived factor 1 (SDF1/CXCL12) and its cognate receptor, CXCR4, play key regulatory roles in CD34+ cell trafficking. We investigated whether AMD3100, a selective CXCR4 antagonist, could mobilize hematopoietic progenitor cells from marrow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22385b35c27272a6f3b24fabb66d472
https://doi.org/10.1182/blood-2003-02-0663
https://doi.org/10.1182/blood-2003-02-0663
Publikováno v:
Transfusion. 40:642-644
BACKGROUND The clinical utility of neutrophil (polymorphonuclear leukocyte, PMN) transfusion therapy has been compromised, in part, by the inability to obtain sufficient quantities of functional neutrophils from donors. Mobilization of PMNs in the pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970c8b744b0934159375f5fb001f718d
https://doi.org/10.1046/j.1537-2995.2000.40060642.x
https://doi.org/10.1046/j.1537-2995.2000.40060642.x
Autor:
Daniel C. Link, Jun Xia, Andrew A. Aprikyan, Steve Stein, Elin Rodger, David C. Dale, Audrey Anna Bolyard
Publikováno v:
British journal of haematology. 147(4)
Severe congenital neutropenia (SCN) is a genetically heterogeneous syndrome associated with mutations of ELANE (ELA2), HAX1, GFI1, WAS, CSF3R or G6PC3. We investigated the prevalence of mutations of ELANE in a cohort of 162 SCN patients for whom bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b6e15063f2e472ff5ace32bb83db68
https://pubmed.ncbi.nlm.nih.gov/19775295
https://pubmed.ncbi.nlm.nih.gov/19775295
Publikováno v:
Transfusion. 45(12)
Background Donor stimulation with granulocyte-colony-stimulating factor (G-CSF) has increased the number of neutrophils (PMNs) that can be collected for granulocyte transfusion therapy. Clinical utility, however, has been limited by the inability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21054227033ef6be552adcb5f2b392f8
https://pubmed.ncbi.nlm.nih.gov/16371040
https://pubmed.ncbi.nlm.nih.gov/16371040
Autor:
Jeffrey Christensen, David C. Dale, Christine Dehner, Brent L. Wood, Elin Rodger, Gary Calandra, Karin Badel, Thomas H. Price, Hal E. Broxmeyer, W. Conrad Liles
Publikováno v:
Transfusion. 45(3)
BACKGROUND: AMD3100, a selective antagonist of CXCR4, rapidly mobilizes CD34+ hematopoietic progenitor cells (HPCs) from marrow to peripheral blood with minimal side effects. STUDY DESIGN AND METHODS: To further investigate potential clinical utility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f817054b89324da1bb4219a60a33ab
https://pubmed.ncbi.nlm.nih.gov/15752146
https://pubmed.ncbi.nlm.nih.gov/15752146
Autor:
W. Conrad Liles, Laurence A. Boxer, Andrew A.G. Aprikyan, Tatyana Kutyavin, David C. Dale, Pavel Aprikian, Steven Stein, Elin Rodger
Publikováno v:
Federal Register
Severe congenital neutropenia (SCN) is a rare hematological disease characterized by a selective decrease in the level of circulating neutrophils in peripheral blood, maturation arrest at the promyelocyte stage of differentiation in the bone marrow,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca92787ff561ac1492e7fa7037d9cb7c
https://pubmed.ncbi.nlm.nih.gov/27737239
https://pubmed.ncbi.nlm.nih.gov/27737239