Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Elin Lehrmann"'
Autor:
Qian Yang, Michael Patrick, Jian Lu, Joseph Chen, Yongqing Zhang, Humza Hemani, Elin Lehrmann, Supriyo De, Nan-ping Weng
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell activation is a tightly controlled process involving both positive and negative regulators. The precise mechanisms governing the negative regulators in T cell proliferation remain incompletely understood. Here, we report that homeodomain-only
Externí odkaz:
https://doaj.org/article/d48f124f5e504222a3d352cb63036beb
Autor:
Ruin Moaddel, Cristan A. Farmer, Mani Yavi, Bashkim Kadriu, Min Zhu, Jinshui Fan, Qinghua Chen, Elin Lehrmann, Giovanna Fantoni, Supriyo De, Caio H. Mazucanti, Elia E. Acevedo-Diaz, Peixiong Yuan, Todd D. Gould, Lawrence T. Park, Josephine M. Egan, Luigi Ferrucci, Carlos A. Zarate, Jr.
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108527- (2023)
Summary: Ketamine is a treatment for both refractory depression and chronic pain syndromes. In order to explore ketamine’s potential mechanism of action and whether ketamine or its metabolites cross the blood brain barrier, we examined the pharmaco
Externí odkaz:
https://doaj.org/article/dd7ad1b3a925423d97ebe742d4f5433a
Autor:
Marina Weiler, Kevin C. Stieger, Kavisha Shroff, Jessie P. Klein, William H. Wood, Yongqing Zhang, Prabha Chandrasekaran, Elin Lehrmann, Simonetta Camandola, Jeffrey M. Long, Mark P. Mattson, Kevin G. Becker, Peter R. Rapp
Publikováno v:
Frontiers in Human Neuroscience, Vol 17 (2023)
IntroductionTranscranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several neurologi
Externí odkaz:
https://doaj.org/article/34f79dae29cb47b98cb8b8caed4990f0
Autor:
Amanda J Stock, Ross A McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G Becker, Elin Lehrmann, William H Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010506 (2022)
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders. One
Externí odkaz:
https://doaj.org/article/42f878754db94ac392eb2d05bf6182d1
Autor:
Yoo Kim, Sudeep Gautam, Kanikkai Raja Aseer, Jaekwan Kim, Prabha Chandrasekaran, Caio Henrique Mazucanti, Paritosh Ghosh, Jennifer F. O’Connell, Máire E. Doyle, Ashley Appleton, Elin Lehrmann, Qing-Rong Liu, Josephine M. Egan
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-13 (2020)
Abstract Cannabinoid 1 receptor (CB1R) expression is upregulated in the liver with viral hepatitis, cirrhosis, and both alcoholic and non-alcoholic fatty liver disease (FLD), whereas its expression is muted under usual physiological conditions. Inhib
Externí odkaz:
https://doaj.org/article/9666fd9589f04fc68c08c674919873b5
Autor:
BreAnna Cameron, Elin Lehrmann, Tien Chih, Joseph Walters, Richard Buksch, Sara Snyder, Joy Goffena, Frances Lefcort, Kevin G. Becker, Lynn George
Publikováno v:
Biology Open, Vol 10, Iss 9 (2021)
Elongator dysfunction is increasingly recognized as a contributor to multiple neurodevelopmental and neurodegenerative disorders including familial dysautonomia, intellectual disability, amyotrophic lateral sclerosis, and autism spectrum disorder. Al
Externí odkaz:
https://doaj.org/article/f10f606d983743c4bc6ad48340bb8bb1
Autor:
Seung Kyu Lee, Yutong Xue, Weiping Shen, Yongqing Zhang, Yuyoung Joo, Muzammil Ahmad, Madoka Chinen, Yi Ding, Wai Lim Ku, Supriyo De, Elin Lehrmann, Kevin G. Becker, Elissa P. Lei, Keji Zhao, Sige Zou, Alexei Sharov, Weidong Wang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced s
Externí odkaz:
https://doaj.org/article/35a40d0fb3f544fea381f448c5f2549b
Autor:
Nicole S Arnold, Nicole Noren Hooten, Yongqing Zhang, Elin Lehrmann, William Wood, Wendy Camejo Nunez, Roland J Thorpe, Michele K Evans, Douglas F Dluzen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239654 (2020)
Socioeconomic status (SES), living in poverty, and other social determinants of health contribute to health disparities in the United States. African American (AA) men living below poverty in Baltimore City have a higher incidence of mortality when c
Externí odkaz:
https://doaj.org/article/9ad6ae479b81423799ac04e4de0c8063
Autor:
Yongqing Zhang, Wen Wei, Victoria Shilova, Natalia N. Petrashevskaya, Valentina I. Zernetkina, Yulia N. Grigorova, Courtney A. Marshall, Rachel C. Fenner, Elin Lehrmann, William H. Wood, Kevin G. Becker, Edward G. Lakatta, Alexei Y. Bagrov, Olga V. Fedorova
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 20 (2019)
Background Elevated levels of an endogenous Na/K‐ATPase inhibitor marinobufagenin accompany salt‐sensitive hypertension and are implicated in cardiac fibrosis. Immunoneutralization of marinobufagenin reduces blood pressure in Dahl salt‐sensitiv
Externí odkaz:
https://doaj.org/article/fb4c877d14ae48b7bffe924ca4b81eff
Autor:
Joy Goffena, Frances Lefcort, Yongqing Zhang, Elin Lehrmann, Marta Chaverra, Jehremy Felig, Joseph Walters, Richard Buksch, Kevin G. Becker, Lynn George
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Familial dysautonomia is linked to mutations in IKBKAP, a scaffolding protein for the Elongator complex, which regulates codon-biased gene translation in yeast. Here the authors show in mammalian neurons that IKBKAP loss alters expression of codon-bi
Externí odkaz:
https://doaj.org/article/b3d0607b35bc41de8e95899931217012