Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elin Jerremalm"'
Publikováno v:
Journal of Pharmaceutical Sciences. 98:3879-3885
Oxaliplatin is used primarily in the treatment of metastatic colorectal cancer. In this minireview, we discuss potentially important biotransformation pathways in light of its short elimination half-life in vivo. We also highlight new information ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c8cf9bd474b20612b2c25e42b2d6a8
https://doi.org/10.1002/jps.21732
https://doi.org/10.1002/jps.21732
Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity
Autor:
Emma Hernlund, Staffan Eksborg, Elin Jerremalm, Inger Wallin, Maria C. Shoshan, Sofi E. Eriksson, Maria Berndtsson, Victoria Hellberg, Göran Laurell, Elias S.J. Arnér, Hans Ehrsson
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Cisplatin is a cornerstone anticancer drug with pronounced ototoxicity, whereas oxaliplatin, a platinum derivative with a different clinical profile, is rarely ototoxic. This difference has not been explained. Methods In HCT116 cells, cisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e79bcccfa121c45e9265befcf128b85
https://doi.org/10.1093/jnci/djn418
https://doi.org/10.1093/jnci/djn418
Publikováno v:
European Journal of Pharmaceutical Sciences. 28:278-283
Oxaliplatin undergoes extensive non-enzymatic chemical transformation in the body. Complexes with sulphur-containing compounds have previously been found in plasma from patients treated with oxaliplatin. We have studied the kinetics for the reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48fd97035b352e58555f8a9e1516839
https://doi.org/10.1016/j.ejps.2006.03.001
https://doi.org/10.1016/j.ejps.2006.03.001
Publikováno v:
Journal of Pharmaceutical Sciences. 92:436-438
Alkaline hydrolysis of the platinum anticancer drug oxaliplatin gives the oxalato monodentate complex and the dihydrated oxaliplatin complex in two consecutive steps. The acid dissociation constant for the oxalato monodentate intermediate was determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7461df5b5f5af243ea84ba2a8853232
https://doi.org/10.1002/jps.10306
https://doi.org/10.1002/jps.10306
Publikováno v:
Journal of Negative Results in Biomedicine
Background. Oxaliplatin is a platinum-based chemotherapeutic drug. Neurotoxicity is the dose-limiting side effect. Previous investigations have reported that acute neurotoxicity could be mediated via voltage-gated ion channels. A possible mechanism f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9591dd3cf0060548de78862a7dfc5a
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18758
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18758
Publikováno v:
Free radical biologymedicine. 39(5)
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant defense, and redox signaling. Together with glutathione reductase (GR) it is the main enzyme providing reducing equivalents to many cellular processes. GR and Trx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2197dd7e96922d03aefc03ae30bdbc39
https://pubmed.ncbi.nlm.nih.gov/16085187
https://pubmed.ncbi.nlm.nih.gov/16085187
Publikováno v:
Pharmaceutical research. 21(5)
To study the degradation of oxaliplatin in chloride media and evaluate the cytotoxicity of oxaliplatin in normal and chloride-deficient medium.The products of the reaction of oxaliplatin with chloride were separated on a Hypercarb S column with a mob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff45e8520b5b2b2d7d37fa9cab9cd73
https://pubmed.ncbi.nlm.nih.gov/15180350
https://pubmed.ncbi.nlm.nih.gov/15180350
Autor:
Staffan Eksborg, Tomas Bergman, Gunvor Alvelius, Elin Jerremalm, Pernilla Videhult, William J. Griffiths, Hans Ehrsson
Publikováno v:
Journal of pharmaceutical sciences. 91(10)
The alkaline degradation of the chemotherapeutic agent oxaliplatin has been studied using liquid chromatography. The oxalato ligand is lost in two consecutive steps. First, the oxalato ring is opened, forming an oxalato monodentate intermediate, as i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d9641e81c145e0151d78c0520fbc83
https://pubmed.ncbi.nlm.nih.gov/12226839
https://pubmed.ncbi.nlm.nih.gov/12226839
Publikováno v:
Cancer letters. 180(2)
A new way of synthesizing the dihydrated oxaliplatin complex (DOC) is presented and its cytotoxicity is compared to that of oxaliplatin and cisplatin. By hydrolyzing oxaliplatin in aqueous sodium hydroxide at 70 degrees C, DOC was formed in less than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748a762bf82b21a98b97379c788c44bf
https://pubmed.ncbi.nlm.nih.gov/12175551
https://pubmed.ncbi.nlm.nih.gov/12175551
Publikováno v:
Pharmaceutical Research; May2004, Vol. 21 Issue 5, p891-894, 4p