Výsledky vyhledávání - "Elin Bergseng"

Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides

Autor: Chu-Young Kim, Elin Bergseng, Mallur S. Madhusudhan, Priya Jayaraman, Ludvig M. Sollid, Thanh Binh Nguyen

Publikováno v: Journal of Biological Chemistry. 292:9218-9228

Human leukocyte antigen (HLA)-DQ2.5 (DQA1*05/DQB1*02) is a class-II major histocompatibility complex protein associated with both type 1 diabetes and celiac disease. One unusual feature of DQ2.5 is its high class-II-associated invariant chain peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efb059e7dcdc145cedb13b8136f69c5
https://doi.org/10.1074/jbc.m117.785139

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Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease

Autor: Knut E.A. Lundin, Ludvig M. Sollid, Shuo-Wang Qiao, Elin Bergseng, Asbjørn Christophersen, Louise Fremgaard Risnes

Publikováno v: The Journal of Immunology. 196:2819-2826

Celiac disease (CD) is an HLA-associated disorder characterized by a harmful T cell response to dietary gluten. It is not understood why most individuals who carry CD-associated HLA molecules, such as HLA-DQ2.5, do not develop CD despite continuous g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966dfccf180a4fbba130b81dfa751a68
https://doi.org/10.4049/jimmunol.1501152

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Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires

Autor: Ludvig M. Sollid, Søren Buus, Magnus Ø. Arntzen, Gustavo A. de Souza, Ståle Nygård, Siri Dørum, Morten Nielsen, Elin Bergseng

Publikováno v: Bergseng, E, Dørum, S, Arntzen, M Ø, Nielsen, M, Nygård, S, Buus, S, de Souza, G A & Sollid, L M 2014, ' Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires ', Immunogenetics, vol. 67, no. 2, pp. 73-84 . https://doi.org/10.1007/s00251-014-0819-9
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Immunogenetics

Celiac disease is caused by intolerance to cereal gluten proteins, and HLA-DQ molecules are involved in the disease pathogenesis by presentation of gluten peptides to CD4+ T cells. The α- or β-chain sharing HLA molecules DQ2.5, DQ2.2, and DQ7.5 dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021ab1917748593700a41af8fe83faf2
https://doi.org/10.1007/s00251-014-0819-9

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A TCRα framework–centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions

Autor: Elin Bergseng, Inger Sandlie, Knut E.A. Lundin, Lene Støkken Høydahl, Louise Fremgaard Risnes, M. Fleur du Pré, Shiva Dahal-Koirala, Ralf Stefan Neumann, Rahel Frick, Geir Åge Løset, Kristin Støen Gunnarsen, Bjørn Dalhus, Shuo-Wang Qiao, Terje Frigstad, Ludvig M. Sollid

Publikováno v: JCI Insight. 2

Selection of biased T cell receptor (TCR) repertoires across individuals is seen in both infectious diseases and autoimmunity, but the underlying molecular basis leading to these shared repertoires remains unclear. Celiac disease (CD) occurs primaril

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a795ac939ebcb3eee73f3887f1d468f5
https://doi.org/10.1172/jci.insight.95193

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Tetramer‐visualized gluten‐specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge

Autor: Knut Ea Lundin, Jørgen Jahnsen, Shuo-Wang Qiao, Asbjørn Christophersen, Elin Bergseng, Melinda Ráki, Ludvig M. Sollid

Publikováno v: United European Gastroenterology Journal. 2:268-278

Background: Diagnosing coeliac disease (CD) can be challenging, despite highly specific autoantibodies and typical mucosal changes in the small intestine. The T-cell response to gluten is a hallmark of the disease that has been hitherto unexploited i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6ec07f8abcf56395a83d4d05f94d08
https://doi.org/10.1177/2050640614540154

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Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease

Autor: Jørgen Jahnsen, Michael Bodd, Ludvig M. Sollid, Elin Bergseng, Knut E.A. Lundin, Melinda Ráki

Publikováno v: European Journal of Immunology. 43:2605-2612

Knowledge of the frequency of disease-driving CD4⁺ T cells in lesions of chronic human inflammatory diseases is limited. In celiac disease (CD), intestinal gluten-reactive CD4⁺ T cells, which recognize gluten peptides only in the context of the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28266de0e5d2da40d0740065452746b7
https://doi.org/10.1002/eji.201343382

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Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes

Autor: Elin Bergseng, Magnus Ø. Arntzen, Siri Dørum, Ludvig M. Sollid, Øyvind Steinsbø, Gustavo A. de Souza

Publikováno v: Scientific Reports

This study aimed to identify proteolytic fragments of gluten proteins recognized by recombinant IgG1 monoclonal antibodies generated from single IgA plasma cells of celiac disease lesions. Peptides bound by monoclonal antibodies in complex gut-enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6668eb0ddb72967291aace7f060054
https://doi.org/10.1038/srep25565

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Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells

Autor: Stig Tollefsen, Ludvig M. Sollid, Michael Bodd, Knut E.A. Lundin, Elin Bergseng

Publikováno v: Human Immunology. 73:376-381

We describe the gluten T-cell response of a DR7DQ2/DR9DQ9 heterozygous celiac disease patient (CD555). Interestingly, this patient had T cells recognizing gluten in the context of human leukocyte antigen (HLA) molecules of both haplotypes. For the DR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6856e7fb0514097c1f9ab6f154cf5610
https://doi.org/10.1016/j.humimm.2012.01.016

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Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation

Autor: Chu-Young Kim, Ludvig M. Sollid, Elin Bergseng, Axel Berg-Larsen, Lars Egil Fallang, Kinya Hotta

Publikováno v: Nature Immunology. 10:1096-1101

Celiac disease driven by an antigluten T cell response is strongly associated with the histocompatibility antigen HLA-DQ2.5 but is barely associated with HLA-DQ2.2. Yet these molecules have very similar peptide-binding motifs and both present gluten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3f16ced407cb15af5afb04ccaeef30
https://doi.org/10.1038/ni.1780

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