Výsledky vyhledávání - "Elin, Eneberg"

Practical Application of Rodent Transporter Knockout Models to Assess Brain Penetration in Drug Discovery

Autor: Elin, Eneberg, Christopher R, Jones, Thomas, Jensen, Kristine, Langthaler, Christoffer, Bundgaard

Publikováno v: Drug Metabolism and Bioanalysis Letters. 15:12-21

Background & Objective: Compound X is a drug candidate for the treatment of neurodegenerative diseases. Its brain distribution was evaluated as part of the lead identification and optimization activities undertaken in early drug discovery. Methods: T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95428b4988e820ca3e970fb9b656fb8
https://doi.org/10.2174/1872312815666220222091032

Zobrazit plný text záznamu

Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established

Autor: Kristine, Langthaler, Christopher R, Jones, Rasmus B, Christensen, Elin, Eneberg, Birger, Brodin, Christoffer, Bundgaard

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 52(6)

The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::584417b35aa014d2d8c0f47b083d03df
https://pubmed.ncbi.nlm.nih.gov/36000364

Zobrazit plný text záznamu

Plný text ve formátu HTML

Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies

Autor: Kristine Langthaler, Christopher R. Jones, Rasmus B. Christensen, Elin Eneberg, Birger Brodin, Christoffer Bundgaard

Publikováno v: Langthaler, K, Jones, C R, Christensen, R B, Eneberg, E, Brodin, B & Bundgaard, C 2022, ' Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies ', Xenobiotica, vol. 52, no. 6, pp. 591-607 . https://doi.org/10.1080/00498254.2022.2115425

1. The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study was to evaluate in vitro to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9a985090dc52f86a8ea6da97f6ab96
https://curis.ku.dk/portal/da/publications/characterisation-of-intravenous-pharmacokinetics-in-goettingen-minipig-and-clearance-prediction-using-established-in-vitro-to-in-vivo-extrapolation-methodologies(04651409-04f2-4166-9cde-13f0f77f14d0).html

Zobrazit plný text záznamu

Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

Autor: Lassina Badolo, Burak Ozgür, Kristine Langthaler, Dino Montanari, Anne-Marie Jacobsen, Elin Eneberg, Christian Janfelt, Birger Brodin, Lasse Saaby

Publikováno v: Ozgür, B, Saaby, L, Janfelt, C, Langthaler, K, Eneberg, E, Jacobsen, A-M, Badolo, L, Montanari, D & Larsen, B B 2021, ' Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp : In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 169, pp. 211-219 . https://doi.org/10.1016/j.ejpb.2021.10.006

Drug efflux by P-glycoprotein (P-gp, ABCB1) is considered as a major obstacle for brain drug delivery for small molecules. P-gp-expressing cell monolayers are used for screening of new drug candidates during early states of drug development. It is, h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c43f647fb9c083c0f9285ad5c8463e
https://pubmed.ncbi.nlm.nih.gov/34756975

Zobrazit plný text záznamu

Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

Autor: Lars Kyhn Rasmussen, Jan Kehler, Elin Eneberg, Todor V. Gerdjikov, Jesper F. Bastlund, Jessica Hayes, Morten Langgård, Bettina Laursen

Publikováno v: Neuropharmacology. 186

Positive modulation of cAMP signalling by phosphodiesterase (PDE) inhibitors has recently been explored as a potential target for the reversal of cognitive and behavioural deficits implicating the corticoaccumbal circuit. Previous studies show that P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b597c388792164dc058ff27f11820f7f
https://pubmed.ncbi.nlm.nih.gov/33444639

Zobrazit plný text záznamu

P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in vivo

Autor: Christoffer Bundgaard, Connie Sanchez, Elin Eneberg

Publikováno v: Neuropharmacology. 103

P-glycoprotein (P-gp)-mediated brain efflux of xenobiotics is a well-known process, which may result in suboptimal target engagement and consequently reduced efficacy of drugs exerting their therapeutic effects in the central nervous system. In the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3903f3198adeddb0dd01cc35380e5a
https://pubmed.ncbi.nlm.nih.gov/26700248

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání