Výsledky vyhledávání - "Elijah H. Gold"

Angiotensin converting enzyme inhibitors: spirapril and related compounds

Autor: Thomas Baum, Gerald F. Swiss, Elijah H. Gold, Paul McNamara, Elizabeth M. Smith, Neustadt Bernard R, Edmund J. Sybertz

Publikováno v: Journal of Medicinal Chemistry. 32:1600-1606

The synthesis of spirapril (5), spiraprilat (25), their RSS stereoisomers, and their glycyl (18b) and lysyl (36, 37) analogues is described. These compounds were evaluated in vivo for inhibition of angiotensin converting enzyme (ACE), and selected co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a31d9e1ab6425deb4e66336ea82c74
https://doi.org/10.1021/jm00127a033

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Synthesis and pharmacological activity of angiotensin-converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines

Autor: Arthur Brown, Rosa Moran, Gerald F. Swiss, Elizabeth M. Smith, Thomas Baum, Peter J.S. Chiu, Edmund J. Sybertz, Elijah H. Gold, Jane A. Sommer, Neustadt Bernard R

Publikováno v: Journal of Medicinal Chemistry. 31:875-885

The synthesis of a series of N-(mercaptoacyl)-4-substituted-(S)-prolines (2 and 3) is described. These compounds were evaluated in vitro for inhibition of angiotensin-converting enzyme (ACE), and selected compounds were evaluated in vivo for ACE inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c69020f4bf676536af2d65370664e9
https://doi.org/10.1021/jm00399a033

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ChemInform Abstract: SYNTHESIS AND COMPARISON OF SOME CARDIOVASCULAR PROPERTIES OF THE STEREOISOMERS OF LABETALOL

Autor: Nicholas Prioli, Elijah H. Gold, Wei Chang, Thomas Baum, Marvin P. Cohen, Stewart Ehrreich, Gordon Johnson, Edmund J. Sybertz

Publikováno v: Chemischer Informationsdienst. 14

A useful method for the separation of labetalol into its two racemic diastereomers, as well as a stereoselective synthesis of its four stereoisomers, is described. The absolute stereochemistry of each isomer was determined by analysis of the DC spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f22d7d32e4f9cd1bf8147f07467458a8
https://doi.org/10.1002/chin.198317161

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Benzazepines: Structure-Activity Relationships Between D1 Receptor Blockade and Selected Pharmacological Effects

Autor: Allen Barnett, William Billard, Louis C. Iorio, Elijah H. Gold

Publikováno v: Neurobiology of Central D1-Dopamine Receptors ISBN: 9781468451931

SCH 23390 is (R)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepine. Its synthesis was based on the benzazepine series synthesized more than 15 years ago by Dr. Lewis Walter and Mr. Wei Chang at Schering Research Laboratori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0fddb5b31f60773e264002293500a4b
https://doi.org/10.1007/978-1-4684-5191-7_1

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