A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell patients

Autor: Evrim Goksel, Elif Ugurel, Elie Nader, Camille Boisson, Ingrid Muniansi, Philippe Joly, Celine Renoux, Alexandra Gauthier, Philippe Connes, Ozlem Yalcin

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the mechanical obstruction of the microcirculation by poorly deformable red blood

Externí odkaz: https://doaj.org/article/696fcdb0ef6c44958115c59db77ec523

Proteomic Analysis of the Role of the Adenylyl Cyclase–cAMP Pathway in Red Blood Cell Mechanical Responses

Autor: Elif Ugurel, Evrim Goksel, Neslihan Cilek, Elif Kaga, Ozlem Yalcin

Publikováno v: Cells, Vol 11, Iss 7, p 1250 (2022)

Red blood cell (RBC) deformability is modulated by the phosphorylation status of the cytoskeletal proteins that regulate the interactions of integral transmembrane complexes. Proteomic studies have revealed that receptor-related signaling molecules a

Externí odkaz: https://doaj.org/article/b3c29e09d8984aaca4e74bc11208680e

Alterations of erythrocyte rheology and cellular susceptibility in end stage renal disease: Effects of peritoneal dialysis.

Autor: Nesrin Zeynep Ertan, Semra Bozfakioglu, Elif Ugurel, Mukaddes Sinan, Ozlem Yalcin

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171371 (2017)

In this study, we investigated the effects of peritoneal dialysis on hemorheological and hematological parameters and their relations with oxidant and antioxidant status of uremic patients. Hemorheological parameters (erythrocyte deformability, eryth

Externí odkaz: https://doaj.org/article/0026fc827966431ba3cb8325a23cb778

Nitrite may serve as a combination partner and a biomarker for the anti-cancer activity of RRx-001

Autor: Elif Ugurel, Bryan Oronsky, Pedro Cabrales, Ozlem Yalcin, Ali Cenk Aksu, Selma Cirrik

Publikováno v: Biorheology. 56:221-235

BACKGROUND RRx-001 is an anti-cancer immunotherapeutic that increases the sensitivity of drug resistant tumors via multiple mechanisms which involve binding to hemoglobin and enhancing nitrite reductase activity of deoxyhemoglobin. OBJECTIVE In the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23812f326cf78fd2db2ed48fadb22a33
https://doi.org/10.3233/bir-190213

Differential effects of adenylyl cyclase-protein kinase A cascade on shear-induced changes of sickle cell deformability

Autor: Gokce Yavas, Philippe Joly, Giovanna Cannas, Yves Bertrand, Philippe Connes, Céline Renoux, Mine Turkay, Alexandra Gauthier, Buse Eglenen, Ozlem Yalcin, Arnaud Hot, Elif Ugurel, Ali Cenk Aksu

Publikováno v: Clinical Hemorheology and Microcirculation
Clinical Hemorheology and Microcirculation, IOS Press, 2020, 73 (4), pp.531-543. ⟨10.3233/CH-190563⟩

BACKGROUND Erythrocyte deformability is impaired in sickle cell disease (SCD). The regulation of cytoskeletal protein organization plays a key role in erythrocyte deformability. The activation of adenylyl cyclase (AC)/cAMP/Protein kinase A (PKA) sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2d5b8dbfeb7174e079f9ffb3fdc907
https://hal-univ-lyon1.archives-ouvertes.fr/hal-02459229