Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elif Tunc-Ozcan"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Rawat et al. demonstrate that activation of adult-born immature hippocampal neurons is necessary and sufficient for the acute antidepressant effects of low-dose ketamine in mice.
Externí odkaz:
https://doaj.org/article/603e7e0a9e5d473ea53124ab66c8e56e
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
It is unclear if there is a causal link between increased neurogenesis and altered affective behaviors in major depressive disorders. Here, the authors show that selectively suppressing the excitability of newborn neurons, without altering neurogenes
Externí odkaz:
https://doaj.org/article/97472875d4a74b7fa186df11b37d1767
Autor:
Jacqueline A. Bonds, Elif Tunc-Ozcan, Sara R. Dunlop, Radhika Rawat, Chian-Yu Peng, John A. Kessler
Publikováno v:
eNeuro.
Inbred mice (C57Bl/6) display wide variability in performance on hippocampal-dependent cognitive tasks. Examination of microdissected dentate gyrus (DG) after cognitive testing showed a highly significant negative correlation between levels of bone m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a33ce446634d3e01090cf096b077afb
https://pubmed.ncbi.nlm.nih.gov/36596594
https://pubmed.ncbi.nlm.nih.gov/36596594
Autor:
Elif Tunc-Ozcan, Sarah M. Brooker, Jacqueline A. Bonds, Yung-Hsu Tsai, Radhika Rawat, Tammy L. McGuire, Chian-Yu Peng, John A. Kessler
Publikováno v:
Cell Mol Life Sci
The benefits of current treatments for depression are limited by low response rates, delayed therapeutic effects, and multiple side effects. Antidepressants affect a variety of neurotransmitter systems in different areas of the brain, and the mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd007db243953cabcb501bb07325fb31
https://doi.org/10.1007/s00018-021-04026-y
https://doi.org/10.1007/s00018-021-04026-y
Publikováno v:
Hormones and Behavior. 82:1-10
The neurodevelopmental fetal alcohol spectrum disorder (FASD) is characterized by cognitive and behavioral deficits in the offspring. Conferring the deficits to the next generation would increase overall FASD disease burden and prevention of this tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d55ddcef145402505fdf069104a1ff
https://doi.org/10.1016/j.yhbeh.2016.04.002
https://doi.org/10.1016/j.yhbeh.2016.04.002
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The etiology of major depressive disorder (MDD), the leading cause of worldwide disability, is unknown. The neurogenic hypothesis proposes that MDD is linked to impairments of adult neurogenesis in the hippocampal dentate gyrus (DG), while the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08a9436270bd009a75c166f5a0dbc49
https://pubmed.ncbi.nlm.nih.gov/31434877
https://pubmed.ncbi.nlm.nih.gov/31434877
Autor:
Eva E. Redei, Stephanie L. Wert, Elif Tunc-Ozcan, Patrick H. Lim, Robert A. Marr, Adriana Ferreira
Publikováno v:
Behavioural brain research. 353
Aging and major depressive disorder are risk factors for dementia , including Alzheimer’s Disease (AD), but the mechanism(s) linking depression and dementia are not known. Both AD and depression show greater prevalence in women. We began to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45fc2bca63d770bd7c3a0e2fa38463c
https://pubmed.ncbi.nlm.nih.gov/29490235
https://pubmed.ncbi.nlm.nih.gov/29490235
Publikováno v:
Molecular psychiatry. 23(7)
Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2-11% of children worldwide, with no effective treatments. Hippocampus-based learning and memory deficits are key symptoms of FASD. Our previous studies show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c6c809b63d2a10f1852e29dd3380c6
https://pubmed.ncbi.nlm.nih.gov/28727687
https://pubmed.ncbi.nlm.nih.gov/28727687
Publikováno v:
Psychoneuroendocrinology. 45:187-191
Insulin-like growth factor 2 (Igf2) regulates development, memory and adult neurogenesis in the hippocampus. Calorie restriction (CR) is known to modulate non-neuronal Igf2 expression intergenerationally, but its effect has not been evaluated on brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab1d1b3e6aecdafa16db03d575d1f06
https://doi.org/10.1016/j.psyneuen.2014.04.002
https://doi.org/10.1016/j.psyneuen.2014.04.002
Background Fetal alcohol spectrum disorder (FASD) is the leading nongenetic cause of mental retardation. There are no treatments for FASD to date. Preclinical in vivo and in vitro studies could help in identifying novel drug targets as for other dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c750d07742c7ba16bba48ac2ed5f09
https://europepmc.org/articles/PMC4889522/
https://europepmc.org/articles/PMC4889522/
