Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Eliezer Mendel Van Allen"'
1
Circulating tumor DNA and homologous recombination deficiency in bone-predominant mCRPC prior to radium-223 therapy
Autor: David Dewei Yang, Jiaming Huang, Jett Crowdis, Irbaz Bin Riaz, Micah Rickles-Young, Junko Tsuji, Carrie Cibulskis, Mark Fleharty, Bridget Whelpley, Kaitlin Kelleher, Julie Fishman, Brendan Michael Reardon, Jihye Park, Franklin W. Huang, Eliezer Mendel Van Allen, Atish Dipankar Choudhury
Publikováno v: Journal of Clinical Oncology. 41:203-203
203 Background: Radium-223 (Ra-223) is a bone-seeking alpha emitter that induces double-stranded DNA breaks, and the homologous recombination (HR) pathway is critical for repairing these breaks. While prior studies suggested that metastatic castrate-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a298961a0b8a0bb949f64ce855d4a5a
https://doi.org/10.1200/jco.2023.41.6_suppl.203
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2
Association of DNA damage repair (DDR) mutations (mts) and clinical outcomes in CALGB 90601 (Alliance)
Autor: Gopa Iyer, Susan Halabi, Bin Luo, Jonathan E. Rosenberg, Woonyoung Choi, Hikmat A. Al-Ahmadie, Jack Mountain, Ashley Marie Regazzi, Megan Fong, Kent William Mouw, Eliezer Mendel Van Allen, David James McConkey, Yujia Wen, Linda McCart, Karla V. Ballman, Himisha Beltran, Michael J. Morris
Publikováno v: Journal of Clinical Oncology. 40:4521-4521
4521 Background: Platinum-based chemotherapy is the standard 1st-line therapy for metastatic urothelial cancer (mUC). C90601 was a randomized phase III trial testing gemcitabine and cisplatin (GC) with bevacizumab (B) or placebo (P) in patients (pts)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53e96ec49863e663cf6b742e88252bf6
https://doi.org/10.1200/jco.2022.40.16_suppl.4521
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3
Cross-trial validation of molecular subtypes in patients with metastatic clear cell renal cell carcinoma (RCC): The JAVELIN Renal 101 experience
Autor: Renee Maria Saliby, Tejas Jammihal, Chris Labaki, Wanling Xie, Robert J. Motzer, Thomas Powles, Brian I. Rini, Laurence Albiges, Sumanta K. Pal, Rana R. McKay, Sabina Signoretti, Sachet A. Shukla, Eliezer Mendel Van Allen, David A. Braun, Toni K. Choueiri
Publikováno v: Journal of Clinical Oncology. 40:4531-4531
4531 Background: Vascular endothelial growth factor (VEGF) and immune checkpoint inhibitors (IO) combinations are a standard in mRCC. Molecular clusters of patients have been identified and correlated with outcomes in the phase 3 IMmotion151 (IM151)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49827a6a848bd839626664ae3803b99d
https://doi.org/10.1200/jco.2022.40.16_suppl.4531
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4
Expanding clinical actionability in individual patient profiles with the Molecular Oncology Almanac
Autor: Brendan Michael Reardon, Eliezer Mendel Van Allen
Publikováno v: Journal of Clinical Oncology. 40:3015-3015
3015 Background: The clinical care of oncology patients is routinely informed by tumor and inherited genetic profiles. This is accomplished by molecular pathologists synthesizing the growing body of clinical guidelines and scientific evidence that as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd95e99108e39e08ed4452e29985aa50
https://doi.org/10.1200/jco.2022.40.16_suppl.3015
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5
Overcoming barriers to tumor genomic profiling through direct patient social media outreach
Autor: Seyram Adjoa Doe-Tetteh, Sabrina Yvonne Camp, Jett Crowdis, Anne Marie Noronha, Dalicia Reales, Tina Alano, Agnes Viale, Mark Donoghue, Nicholas D. Socci, Michael F. Berger, Hikmat A. Al-Ahmadie, Samuel Aaron Funt, Darren R. Feldman, Eli L. Diamond, Eliezer Mendel Van Allen, David B. Solit
Publikováno v: Journal of Clinical Oncology. 40:6532-6532
6532 Background: Tumor genomic profiling is increasingly used to identify actionable genomic alterations as a guide to therapy selection. To overcome barriers to genomic testing for patients with rare cancers, we initiated a program to offer free cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c4b35602511d1a553cf6b813f4f2430
https://doi.org/10.1200/jco.2022.40.16_suppl.6532
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8
A phase Ia/Ib study of talazoparib in combination with tazemetostat in metastatic castration-resistant prostate cancer (mCRPC)
Autor: Atish Dipankar Choudhury, Wanling Xie, Alok Tewari, David Tomoaki Miyamoto, Bose Kochupurakkal, Leigh Ellis, Matthew Bandel, Claire Leisner, Geoffrey Shapiro, Alan D. D'Andrea, Eliezer Mendel Van Allen, Matthew Freedman, Myles Brown, Mary-Ellen Taplin, Himisha Beltran
Publikováno v: Journal of Clinical Oncology. 40:TPS5098-TPS5098
TPS5098 Background: Enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in metastatic castration-resistant prostate cancer (mCRPC), and is linked to lineage plasticity and therapy resistance. In pre-clinical studies, EZH2 directly regulate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34152fe0e6a460e52cfcd29e9c201d40
https://doi.org/10.1200/jco.2022.40.16_suppl.tps5098
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10
A phase Ia/Ib study of talazoparib in combination with tazemetostat in metastatic castration-resistant prostate cancer (mCRPC)
Autor: Atish Dipankar Choudhury, Wanling Xie, Alok Tewari, David Tomoaki Miyamoto, Bose Kochupurakkal, Leigh Ellis, Matthew Bandel, Claire Leisner, Geoffrey Shapiro, Alan D. D'Andrea, Eliezer Mendel Van Allen, Matthew Freedman, Mary-Ellen Taplin, Himisha Beltran
Publikováno v: Journal of Clinical Oncology. 40:TPS195-TPS195
TPS195 Background: Enhancer of zeste homolog 2 (EZH2) is frequently overexpressed in metastatic castration-resistant prostate cancer (mCRPC), and is linked to lineage plasticity and therapy resistance. In pre-clinical studies, EZH2 directly regulates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80b0b2011a6bb6ca054bf0c3fe570613
https://doi.org/10.1200/jco.2022.40.6_suppl.tps195
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