Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Eliezer J, Barreiro"'
Autor:
Amanda Aparecida Ribeiro Andrade, Fernanda Pauli, Carolina Girotto Pressete, Bruno Zavan, João Adolfo Costa Hanemann, Marta Miyazawa, Rafael Fonseca, Ester Siqueira Caixeta, Julia Louise Moreira Nacif, Alexandre Ferro Aissa, Eliezer J. Barreiro, Marisa Ionta
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 892 (2024)
Liver cancer is the second leading cause of cancer-related death in males. It is estimated that approximately one million deaths will occur by 2030 due to hepatic cancer. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer subty
Externí odkaz:
https://doaj.org/article/d692f5991bff4e02bffce40c1293145b
Autor:
Raysa Magali Pillpe-Meza, Wesley Leandro Gouveia, Gisele Barbosa, Carlos A. M. Fraga, Eliezer J. Barreiro, Lidia Moreira Lima
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 389 (2024)
Inappropriate expression of histone deacetylase (HDAC-6) and deregulation of the phosphatidylinositol 3-kinase (PI3K) signalling pathway are common aberrations observed in cancers. LASSBio-2208, has been previously described as a dual inhibitor in th
Externí odkaz:
https://doaj.org/article/15b92ae3e49e46bdb0dc5ade07c73801
Autor:
Hygor M. R. de Souza, Jéssica S. Guedes, Rosana H. C. N. Freitas, Luis G. V. Gelves, Harold H. Fokoue, Carlos Mauricio R. Sant’Anna, Eliezer J. Barreiro, Lidia M. Lima
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 718-727 (2022)
Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. Their presence is often associated with hydrolytic lability. In this paper, we describe a comparative chemical and biological stability of ho
Externí odkaz:
https://doaj.org/article/fbb8bd8c8d3b4bd2995cecac8995a8b1
Autor:
Celina de Jesus Guimarães, Teiliane Rodrigues Carneiro, Marisa Jadna Silva Frederico, Guilherme G. C. de Carvalho, Matthew Little, Valder N. Freire, Victor L. B. França, Daniel Nascimento do Amaral, Jéssica de Siqueira Guedes, Eliezer J. Barreiro, Lídia Moreira Lima, Francisco W. A. Barros-Nepomuceno, Claudia Pessoa
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1282 (2023)
LASSBio-1920 was synthesized due to the poor solubility of its natural precursor, combretastatin A4 (CA4). The cytotoxic potential of the compound against human colorectal cancer cells (HCT-116) and non-small cell lung cancer cells (PC-9) was evaluat
Externí odkaz:
https://doaj.org/article/0cb56bf39fb1423e89a6bf25dc372494
Autor:
Gisele Barbosa, Luis Gabriel Valdivieso Gelves, Caroline Marques Xavier Costa, Lucas Silva Franco, João Alberto Lins de Lima, Cristiane Aparecida-Silva, John Douglas Teixeira, Claudia dos Santos Mermelstein, Eliezer J. Barreiro, Lidia Moreira Lima
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 913 (2022)
Combretastatin A-4 (CA-4, 1) is an antimicrotubule agent used as a prototype for the design of several synthetic analogues with anti-tubulin activity, such as LASSBio-1586 (2). A series of branched and unbranched homologs of the lead-compound 2, and
Externí odkaz:
https://doaj.org/article/8fe7ce838ac14269812abfc874254714
Publikováno v:
Molecules, Vol 26, Iss 23, p 7364 (2021)
In this work, we evaluated the conformational effect promoted by the isosteric exchange of sulfur by selenium in the heteroaromatic ring of new N-acylhydrazone (NAH) derivatives (3–8, 13, 14), analogues of the cardioactive compounds LASSBio-294 (1)
Externí odkaz:
https://doaj.org/article/99b7d1246289408a9b533731cfa72663
Autor:
Jéssica de Siqueira Guedes, Teiliane Rodrigues Carneiro, Pedro de Sena Murteira Pinheiro, Carlos Alberto Manssour Fraga, Carlos Mauricio R. Sant′Anna, Eliezer J. Barreiro, Lídia Moreira Lima
Publikováno v:
ACS Omega. 7:38752-38765
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::379577c4b5a866123e17bc4a39d5b4d0
https://doi.org/10.1021/acsomega.2c04368
https://doi.org/10.1021/acsomega.2c04368
Autor:
Lidia Moreira Lima, Tiago Fernandes da Silva, Carlos Eduardo da Silva Monteiro, Cristiane Aparecida-Silva, Walfrido Bispo Júnior, Aline Cavalcanti de Queiroz, Magna Suzana Alexandre-Moreira, Gisele Zapata-Sudo, Eliezer J. Barreiro
Publikováno v:
Molecules, Vol 26, Iss 16, p 4828 (2021)
Acylhydrazones are still an important framework to the design of new bioactive compounds. As treatment of chronic pain represents a clinical challenge, we decided to modify the structure of LASSBio-1514 (1), previously described as anti-inflammatory
Externí odkaz:
https://doaj.org/article/c0a533780ffc4ea1a2d6a027150272ec
Autor:
Rafaela R. Silva, Lucas T. Parreiras-e-Silva, Thais E.T. Pompeu, Diego A. Duarte, Carlos A.M. Fraga, Eliezer J. Barreiro, Ricardo Menegatti, Claudio M. Costa-Neto, François Noël
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
LASSBio-579, an N-phenylpiperazine antipsychotic lead compound, has been previously reported as a D2 receptor (D2R) ligand with antipsychotic-like activities in rodent models of schizophrenia. In order to better understand the molecular mechanism of
Externí odkaz:
https://doaj.org/article/f45cf0135861424db33630b83e2d0e5f
Autor:
Allan K Alencar, Fábio I Carvalho, Ananssa M Silva, Sabrina T Martinez, Jorge A Calasans-Maia, Carlos M Fraga, Eliezer J Barreiro, Gisele Zapata-Sudo, Roberto T Sudo
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195047 (2018)
Pulmonary hypertension (PH) is characterized by enhanced pulmonary vascular resistance, which causes right ventricle (RV) pressure overload and results in right sided heart failure and death. This work investigated the effectiveness of a combined the
Externí odkaz:
https://doaj.org/article/6f26495eb6ac41b2a7cebda365ef1c25