Výsledky vyhledávání - "Eliezer Falb"

An unusual rearrangement involving 5-bromo-1-phenylpyridone during its methyl cross coupling with turbo-Grignard reagent, leading to a 5-bromopyridone-fused seven-membered carbocyclic ring

Autor: Andrey Tor, Hugo E. Gottlieb, Eliezer Falb, Konstantin Ulanenko, Alfred Hassner, Michal Afri

Publikováno v: Chemistry of Heterocyclic Compounds. 53:979-984

The structure of a cyclohepta[ c ]pyridin-1-one, a product of an unusual transformation, isolated during a turbo-Grignard reagentpromoted methyl cross coupling to 5-bromo-1-phenyl-2-pyridone, was determined by 1 H and 13 C NMR, COSY, and high-resolut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c96b539f7fc9d8e85151ce56e2387a78
https://doi.org/10.1007/s10593-017-2159-9

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A highly efficient Suzuki–Miyaura methylation of pyridines leading to the drug pirfenidone and its CD3 version (SD-560)

Autor: Konstantin Ulanenko, Eliezer Falb, Alfred Hassner, Michal Afri, Hugo E. Gottlieb, Ronen Gottesfeld, Andrey Tor, Michal Weitman

Publikováno v: Green Chem.. 19:5046-5053

Efficient introduction of methyl or methyl-d3 into aromatic and heteroaromatic systems still presents a synthetic challenge. In particular, we were in search of a non-cryogenic synthesis of the 5-CD3 version of pirfenidone (4d, also known as Pirespa�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93fc7cdf226245350ff52af05831af1f
https://doi.org/10.1039/c7gc01740e

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From Amino Acids to Fused Chiral Pyrrolidines and Piperidines via the INOC Route

Autor: Abraham Nudelman, Hugo E. Gottlieb, Eliezer Falb, Alfred Hassner

Publikováno v: European Journal of Organic Chemistry. 2000:645-655

Intramolecular nitrile oxide olefin cycloaddition (INOC) reactions of oximes 1–3 and of 24–27 derived from L-amino acids have been found to proceed stereoselectively, yielding tricyclic fused pyrrolidines and piperidines. Further manipulation led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5b110ba3a8793b29cd84abea22acca5
https://doi.org/10.1002/(sici)1099-0690(200002)2000:4<645::aid-ejoc645>3.0.co

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In situ generation of Fmoc-amino acid chlorides using bis -(trichloromethyl)carbonate and its utilization for difficult couplings in solid-phase peptide synthesis

Autor: Yoseph Salitra, Tamar Yechezkel, Chaim Gilon, Eliezer Falb

Publikováno v: The Journal of Peptide Research. 53:507-517

This paper reports procedures for the straightforward in situ generation of Fmoc-amino acid chlorides using bis-(trichloromethyl)carbonate (BTC) and their utilization for difficult couplings during solid-phase peptide synthesis. The BTC-mediated coup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7686eb2ffe2a0ca9d87715d7a9ca162c
https://doi.org/10.1034/j.1399-3011.1999.00049.x

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IOOC Route to Substituted Chiral Pyrrolidines. Potential Glycosidase Inhibitors

Autor: and Amnon Albeck, Yosi Bechor, Abraham Nudelman, Eliezer Falb, Alfred Hassner, Hugo E. Gottlieb

Publikováno v: The Journal of Organic Chemistry. 64:498-506

Branched-chain five-membered ring aza-sugar analogues, synthesized from amino acids by an intramolecular oxime−olefin cycloaddition reaction, the IOOC route, were found to be selective glycosidase inhibitors. The derivative 2,4(S)-di(hydroxymethyl)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36a86e9f1fdaae4ce316612ed6765f95
https://doi.org/10.1021/jo9815094

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Acetyl Chloride-Methanol as a Convenient Reagent for: A) Quantitative Formation of Amine Hydrochlorides B) Carboxylate Ester Formation C) Mild Removal of N-t-Boc-Protective Group

Autor: Bilha Fischer, Ayelet Nudelman, Eliezer Falb, Barry Arthur Wexler, Yosi Bechor, Abraham Nudelman

Publikováno v: Synthetic Communications. 28:471-474

Hydrogen chloride qualitatively generated in situ by the addition of acetyl chloride to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09d751eeeb53d0885018f13811742a36
https://doi.org/10.1080/00397919808005101

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Utilization of L-serine in an oxime olefin cycloaddition route to a functionalized asymmetric pyrrolidine, a selective α-glucosidase inhibitor

Autor: Eliezer Falb, Hugo E. Gottlieb, Abraham Nudelman, Alfred Hassner, Amnon Albeck

Publikováno v: Tetrahedron Letters. 35:2397-2400

A new route for asymmetric aza-sugar analogs starting with L-serine and utilizing an intramolecular oxime olefin cycloaddition has been successfully developed. A member of this family of branched chain sugar amino di(hydroxymethyl) pyrrolidines ( 1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::504085ab1228d9228902b507a56ab0aa
https://doi.org/10.1016/0040-4039(94)85229-4

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A Convenient Synthesis of Chiral Oxazolidin-2-Ones and Thiazolidin-2-Ones and an Improved Preparation of Triphosgene

Autor: Eliezer Falb, Abraham Nudelman, Alfred Hassner

Publikováno v: Synthetic Communications. 23:2839-2844

Oxazolidin-2-ones and thiazolidin-2-one are conveniently prepared by condensation of L-serine, L-threonine and L-cysteine, respectively with triphosgene. The corresponding methyl esters may be subsequently obtained by quenching the reaction mixture w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d90510cf43376afe8983ead039712fe
https://doi.org/10.1080/00397919308012605

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