Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo.

Autor: Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramaugé Parra, Etienne Kornobis, Eliette Bonnefoy, Xavier Montagutelli

Publikováno v: PLoS Pathogens, Vol 19, Iss 9, p e1011446 (2023)

Zika virus (ZIKV) is a Flavivirus responsible for recent epidemics in Pacific Islands and in the Americas. In humans, the consequences of ZIKV infection range from asymptomatic infection to severe neurological disease such as Guillain-Barré syndrome

Externí odkaz: https://doaj.org/article/4f14a3acc343497b9372e77d19cad9d9

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Autor: Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas

Publikováno v: Neurobiology of Disease, Vol 82, Iss , Pp 540-551 (2015)

The accumulation of DNA and RNA oxidative damage is observed in cortical and hippocampal neurons from Alzheimer's disease (AD) brains at early stages of pathology. We recently reported that Tau is a key nuclear player in the protection of neuronal nu

Externí odkaz: https://doaj.org/article/fbab0ea2d1634afd808af6d99773df9c

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced byIrf3deficiencyin vitrobut requires other variantsin vivo, not linked to the type I interferon response

Autor: Marie Bourdon, Caroline Manet, Laurine Conquet, Corentin Ramauge-Parra, Etienne Kornobis, Eliette Bonnefoy, Xavier Montagutelli

Zika virus (ZIKV) is a Flavivirus responsible for recent epidemics in Pacific Islands and in the Americas. In humans, the consequences of ZIKV infection range from asymptomatic infection to severe neurological disease such as Guillain-Barré syndrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::229d68c118b003b0b5dc72727d40b804
https://doi.org/10.1101/2023.03.27.534491

Emerging Connections Between Tau and Nucleic Acids

Autor: Marie-Christine, Galas, Eliette, Bonnefoy, Luc, Buee, Bruno, Lefebvre

Publikováno v: Advances in experimental medicine and biology. 1184

Connections between tau and nucleic acids have been largely underestimated until recently when several reports highlighted new key roles of tau in relation with DNA and RNA structure, metabolism and integrity, and their implications in the context of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6f5baa7b1823e49e3b467318651ed7c
https://pubmed.ncbi.nlm.nih.gov/32096035

Tau/DDX6 interaction increases microRNA activity

Autor: Hervé Drobecq, Dominique Weil, Melissa Gilles, Luc Buée, Raphaëlle Caillierez, Maggy Chwastyniak, Bruno Lefebvre, Michel Kress, Alban Chauderlier, Eliette Bonnefoy, Andrea Spolcova, Marie-Christine Galas, Florence Pinet

Publikováno v: Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 2018, 1861 (8), pp.762-772. ⟨10.1016/j.bbagrm.2018.06.006⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2018, 1861 (8), pp.762-772. ⟨10.1016/j.bbagrm.2018.06.006⟩
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, Elsevier, 2018, 1861 (8), pp.762-772. ⟨10.1016/j.bbagrm.2018.06.006⟩

International audience; Tauopathies, such as Alzheimer's disease, are characterized by intracellular aggregates of insoluble Tau proteins. Originally described as a microtubule binding protein, recent studies demonstrated additional physiological rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9dc1d4faa617c410e950b14f39fc09c
https://hal.science/hal-02251328