The prognostic relevance of a gene expression signature in MRI-defined highly vascularized glioblastoma

Autor: Víctor Montosa-i-Micó, María del Mar Álvarez-Torres, Rebeca Burgos-Panadero, F. Javier Gil-Terrón, Maria Gómez Mahiques, Carles Lopez-Mateu, Juan M. García-Gómez, Elies Fuster-Garcia

Publikováno v: Heliyon, Vol 10, Iss 11, Pp e31175- (2024)

Background: The vascular heterogeneity of glioblastomas (GB) remains an important area of research, since tumor progression and patient prognosis are closely tied to this feature. With this study, we aim to identify gene expression profiles associate

Externí odkaz: https://doaj.org/article/cdb350ae73874ac5b5eb144d70acd33d

Higher vascularity at infiltrated peripheral edema differentiates proneural glioblastoma subtype.

Autor: Eduard Chelebian, Elies Fuster-Garcia, María Del Mar Álvarez-Torres, Javier Juan-Albarracín, Juan M García-Gómez

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0232500 (2020)

Background and purposeGenetic classifications are crucial for understanding the heterogeneity of glioblastoma. Recently, perfusion MRI techniques have demonstrated associations molecular alterations. In this work, we investigated whether perfusion ma

Externí odkaz: https://doaj.org/article/cbc3fb8c74c64edda91562d5b8269a66

Advanced MR Techniques for Preoperative Glioma Characterization:Part 2

Autor: Gilbert Hangel, Bárbara Schmitz‐Abecassis, Nico Sollmann, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo‐Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernández‐Seara, Julia Furtner, Elies Fuster‐Garcia, Matthew Grech‐Sollars, N. Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Özcan, Esin Ozturk‐Isik, Senol Piskin, Kathleen M. Schmainda, Siri F. Svensson, Chih‐Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes, Lydiane Hirschler, Marion Smits, Jan Petr, Kyrre E. Emblem

Publikováno v: Hangel, G, Schmitz-abecassis, B, Sollmann, N, Pinto, J, Arzanforoosh, F, Barkhof, F, Booth, T, Calvo-imirizaldu, M, Cassia, G, Chmelik, M, Clement, P, Ercan, E, Fernández-seara, M A, Furtner, J, Fuster-garcia, E, Grech-sollars, M, Guven, N T, Hatay, G H, Karami, G, Keil, V C, Kim, M, Koekkoek, J A F, Kukran, S, Mancini, L, Nechifor, R E, Özcan, A, Ozturk-isik, E, Piskin, S, Schmainda, K M, Svensson, S F, Tseng, C, Unnikrishnan, S, Vos, F, Warnert, E, Zhao, M Y, Jancalek, R, Nunes, T, Hirschler, L, Smits, M, Petr, J & Emblem, K E 2023, ' Advanced MR Techniques for Preoperative Glioma Characterization : Part 2 ', Journal of Magnetic Resonance Imaging, vol. 57, no. 6, pp. 1676-1695 . https://doi.org/10.1002/jmri.28663
JOURNAL OF MAGNETIC RESONANCE IMAGING
Hangel, G, Schmitz-Abecassis, B R, Sollmann, N, Pinto, J, Arzanforoosh, F, Barkhof, F, Booth, T, Calvo-Imirizaldu, M, Cassia, G, Chmelik, M, Clement, P, Ercan, E, Fernández-Seara, M A, Furtner, J, Fuster-Garcia, E, Grech-Sollars, M, Guven, N T, Hatay, G H, Karami, G, Keil, V C, Kim, M, Koekkoek, J A F, Kukran, S, Mancini, L, Nechifor, R E, Özcan, A, Ozturk-Isik, E, Piskin, S, Schmainda, K M, Svensson, S F, Tseng, C-H, Unnikrishnan, S, Vos, F, Warnert, E, Zhao, M Y, Jancalek, R, Nunes, T, Hirschler, L, Smits, M, Petr, J & Emblem, K E 2023, ' Advanced MR Techniques for Preoperative Glioma Characterization : Part 2 ', Journal of Magnetic Resonance Imaging, vol. 57, no. 6, pp. 1676-1695 . https://doi.org/10.1002/jmri.28663
Journal of Magnetic Resonance Imaging 57(2023)6, 1676-1695

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1022503bb4aa5e74d26b26d410ee4cac
https://kclpure.kcl.ac.uk/en/publications/ea923c6f-1249-465d-927a-47b0644bbdce

MRI Elastography Identifies Regions of Extracellular Matrix Reorganization Associated with Shorter Survival in Glioblastoma Patients

Autor: Siri Fløgstad Svensson, Skarphéðinn Halldórsson, Anna Latysheva, Elies Fuster-Garcia, Trine Hjørnevik, Jorunn Fraser-Green, Robin Anthony Birkeland Bugge, Jack Grinband, Sverre Holm, Ralph Sinkus, Einar Osland Vik-Mo, Kyrre Eeg Emblem

BackgroundThe biomechanical tissue properties of glioblastoma tumors are heterogeneous, but the molecular mechanisms involved and the biological implications are poorly understood. Here, we combine magnetic resonance elastography (MRE) measurement of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1605764979fbef018f10d15f5bafc297
https://doi.org/10.1101/2022.11.07.22282021

Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival

Autor: Elies Fuster-Garcia, Ivar Thokle Hovden, Siri Fløgstad Svensson, Christopher Larsson, Jonas Vardal, Atle Bjørnerud, Kyrre E. Emblem

Publikováno v: Cancers; Volume 14; Issue 7; Pages: 1725

The compression of peritumoral healthy tissue in brain tumor patients is considered a major cause of the life-threatening neurologic symptoms. Although significant deformations caused by the tumor growth can be observed radiologically, the quantifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c53492e1a78484159484dead3631aa2