Interpreting deep learning models for glioma survival classification using visualization and textual explanations

Autor: Michael Osadebey, Qinghui Liu, Elies Fuster-Garcia, Kyrre E. Emblem

Publikováno v: BMC Medical Informatics and Decision Making, Vol 23, Iss 1, Pp 1-12 (2023)

Abstract Background Saliency-based algorithms are able to explain the relationship between input image pixels and deep-learning model predictions. However, it may be difficult to assess the clinical value of the most important image features and the

Externí odkaz: https://doaj.org/article/87ef5160b36a40ea958482c093e27f95

Advanced MR Techniques for Preoperative Glioma Characterization:Part 2

Autor: Gilbert Hangel, Bárbara Schmitz‐Abecassis, Nico Sollmann, Joana Pinto, Fatemehsadat Arzanforoosh, Frederik Barkhof, Thomas Booth, Marta Calvo‐Imirizaldu, Guilherme Cassia, Marek Chmelik, Patricia Clement, Ece Ercan, Maria A. Fernández‐Seara, Julia Furtner, Elies Fuster‐Garcia, Matthew Grech‐Sollars, N. Tugay Guven, Gokce Hale Hatay, Golestan Karami, Vera C. Keil, Mina Kim, Johan A. F. Koekkoek, Simran Kukran, Laura Mancini, Ruben Emanuel Nechifor, Alpay Özcan, Esin Ozturk‐Isik, Senol Piskin, Kathleen M. Schmainda, Siri F. Svensson, Chih‐Hsien Tseng, Saritha Unnikrishnan, Frans Vos, Esther Warnert, Moss Y. Zhao, Radim Jancalek, Teresa Nunes, Lydiane Hirschler, Marion Smits, Jan Petr, Kyrre E. Emblem

Publikováno v: Hangel, G, Schmitz-abecassis, B, Sollmann, N, Pinto, J, Arzanforoosh, F, Barkhof, F, Booth, T, Calvo-imirizaldu, M, Cassia, G, Chmelik, M, Clement, P, Ercan, E, Fernández-seara, M A, Furtner, J, Fuster-garcia, E, Grech-sollars, M, Guven, N T, Hatay, G H, Karami, G, Keil, V C, Kim, M, Koekkoek, J A F, Kukran, S, Mancini, L, Nechifor, R E, Özcan, A, Ozturk-isik, E, Piskin, S, Schmainda, K M, Svensson, S F, Tseng, C, Unnikrishnan, S, Vos, F, Warnert, E, Zhao, M Y, Jancalek, R, Nunes, T, Hirschler, L, Smits, M, Petr, J & Emblem, K E 2023, ' Advanced MR Techniques for Preoperative Glioma Characterization : Part 2 ', Journal of Magnetic Resonance Imaging, vol. 57, no. 6, pp. 1676-1695 . https://doi.org/10.1002/jmri.28663
JOURNAL OF MAGNETIC RESONANCE IMAGING
Hangel, G, Schmitz-Abecassis, B R, Sollmann, N, Pinto, J, Arzanforoosh, F, Barkhof, F, Booth, T, Calvo-Imirizaldu, M, Cassia, G, Chmelik, M, Clement, P, Ercan, E, Fernández-Seara, M A, Furtner, J, Fuster-Garcia, E, Grech-Sollars, M, Guven, N T, Hatay, G H, Karami, G, Keil, V C, Kim, M, Koekkoek, J A F, Kukran, S, Mancini, L, Nechifor, R E, Özcan, A, Ozturk-Isik, E, Piskin, S, Schmainda, K M, Svensson, S F, Tseng, C-H, Unnikrishnan, S, Vos, F, Warnert, E, Zhao, M Y, Jancalek, R, Nunes, T, Hirschler, L, Smits, M, Petr, J & Emblem, K E 2023, ' Advanced MR Techniques for Preoperative Glioma Characterization : Part 2 ', Journal of Magnetic Resonance Imaging, vol. 57, no. 6, pp. 1676-1695 . https://doi.org/10.1002/jmri.28663
Journal of Magnetic Resonance Imaging 57(2023)6, 1676-1695

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1022503bb4aa5e74d26b26d410ee4cac
https://kclpure.kcl.ac.uk/en/publications/ea923c6f-1249-465d-927a-47b0644bbdce

MRI Elastography Identifies Regions of Extracellular Matrix Reorganization Associated with Shorter Survival in Glioblastoma Patients

Autor: Siri Fløgstad Svensson, Skarphéðinn Halldórsson, Anna Latysheva, Elies Fuster-Garcia, Trine Hjørnevik, Jorunn Fraser-Green, Robin Anthony Birkeland Bugge, Jack Grinband, Sverre Holm, Ralph Sinkus, Einar Osland Vik-Mo, Kyrre Eeg Emblem

BackgroundThe biomechanical tissue properties of glioblastoma tumors are heterogeneous, but the molecular mechanisms involved and the biological implications are poorly understood. Here, we combine magnetic resonance elastography (MRE) measurement of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1605764979fbef018f10d15f5bafc297
https://doi.org/10.1101/2022.11.07.22282021

Quantification of Tissue Compression Identifies High-Grade Glioma Patients with Reduced Survival

Autor: Elies Fuster-Garcia, Ivar Thokle Hovden, Siri Fløgstad Svensson, Christopher Larsson, Jonas Vardal, Atle Bjørnerud, Kyrre E. Emblem

Publikováno v: Cancers; Volume 14; Issue 7; Pages: 1725

The compression of peritumoral healthy tissue in brain tumor patients is considered a major cause of the life-threatening neurologic symptoms. Although significant deformations caused by the tumor growth can be observed radiologically, the quantifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c53492e1a78484159484dead3631aa2

Lack of benefit of temozolomide for MGMT methylated patients with high vascular glioblastoma: a confirmatory study

Autor: Josep Puig, Juan M. García-Gómez, Carmen Balana, María del Mar Álvarez-Torres, Elies Fuster-Garcia

In this study we evaluated the benefit on survival of the combination of MGMT methylation and moderate vascularity in glioblastoma using a retrospective dataset of 123 patients from a multicenter cohort. MRI processing and calculation of relative cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e5d98afb2df80feb6c3dbe592eeefed
https://doi.org/10.1101/2021.09.01.21262673