Výsledky vyhledávání - "Elien M Doorduijn"

Akademický článek

Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase.

Autor: Xiao-Lin Li, Marjolein Sluijter, Elien M Doorduijn, Shubha P Kale, Harris McFerrin, Yong-Yu Liu, Yan Li, Madhusoodanan Mottamal, Xin Yao, Fengkun Du, Baihan Gu, Kim Hoang, Yen H Nguyen, Nichelle Taylor, Chelsea R Stephens, Thorbald van Hall, Qian-Jin Zhang

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e108192 (2014)

The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the induction phase. Many reports indicate that tumor cells transfected with B7-1 induced augment

Externí odkaz: https://doaj.org/article/f19ef3458ca444f3bfe66781882d6c97

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Data from CD4+ T Cell and NK Cell Interplay Key to Regression of MHC Class Ilow Tumors upon TLR7/8 Agonist Therapy

Autor: Thorbald van Hall, Sjoerd H. van der Burg, Ferry Ossendorp, Ramon Arens, Saskia Maas, Serenella Silvestri, Daniela C. Salvatori, Marjolein Sluijter, Elien M. Doorduijn

One of the next challenges in cancer immunotherapy is the resistance of tumors to T-cell–based treatments through loss of MHC class I. Here, we show that under these circumstances, the Toll-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef1d8a3fb684b57b044f7641b1508fc6
https://doi.org/10.1158/2326-6066.c.6549049.v1

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Akademický článek

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes

Autor: Elien M. Doorduijn, Marjolein Sluijter, Bianca J. Querido, Ursula J. E. Seidel, Claudia C. Oliveira, Sjoerd H. van der Burg, Thorbald van Hall

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

The HLA-E homolog in the mouse (Qa-1b) is a conserved MHC class Ib molecule presenting monomorphic peptides to germline-encoded natural killer receptor CD94/NKG2A. Previously, we demonstrated the replacement of this canonical peptide by a diverse pep

Externí odkaz: https://doaj.org/article/ebc3efef40334db0ab6665b07b3054ce

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The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability

Autor: Adnane Achour, Renhua Sun, T. van Hall, Tatyana Sandalova, Marjolein Sluijter, Elien M. Doorduijn, A. Talyzina, I. Hafstrand, Sara Pellegrino, Adil Doganay Duru

Publikováno v: The Journal of Immunology. 200:2860-2868

Human cancers frequently display defects in Ag processing and presentation allowing for immune evasion, and they therefore constitute a significant challenge for T cell–based immunotherapy. We have previously demonstrated that the antigenicity of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df46dc6828378468a08e164dac244a0c
https://doi.org/10.4049/jimmunol.1700228

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TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I-low cancers

Autor: Thorbald van Hall, Koen A. Marijt, Elien M. Doorduijn

Publikováno v: Molecular Immunology, 113, 43-49

T-cell based immunotherapies through checkpoint blockade or adoptive transfer are effective treatments for a wide range of cancers like melanomas and lung carcinomas that harbor a high mutational load. The HLA class I and class II (HLA-I and HLA-II)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18883092ff25cdfce8744025ce3c5451
https://doi.org/10.1016/j.molimm.2018.03.029

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T cells specific for a TAP-independent self-peptide remain naive in tumor-bearing mice and are fully exploitable for therapy

Autor: Bianca Querido, Marjolein Sluijter, Elien M. Doorduijn, Koen A. Marijt, Sjoerd H. van der Burg, Thorbald van Hall

Publikováno v: OncoImmunology
OncoImmunology, Vol 7, Iss 3 (2018)
OncoImmunology, 7(3)
Oncoimmunology

Cancers frequently evade immune-recognition by lowering peptide:MHC-I complexes on their cell surface. Limited peptide supply due to TAP-deficiency results in such MHC-Ilow immune-escape variants. Previously, we reported on a category of TAP-independ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf44fb1c1984dc49c2a0c034c086f1e
https://doi.org/10.1080/2162402x.2017.1382793

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T cells engaging the conserved Mhc class ib Molecule Qa-1(b) with TaP-independent Peptides are semi-invariant lymphocytes

Autor: Ursula J. E. Seidel, Elien M. Doorduijn, Marjolein Sluijter, Thorbald van Hall, Bianca Querido, Cláudia C. Oliveira, Sjoerd H. van der Burg

Publikováno v: Frontiers in Immunology, 9
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e6b3863f20f8d67900b4fd9decf26d
https://www.frontiersin.org/articles/10.3389/fimmu.2018.00060/full

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