The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

Autor: Elie J. Diner, Dara L. Burdette, Stephen C. Wilson, Kathryn M. Monroe, Colleen A. Kellenberger, Mamoru Hyodo, Yoshihiro Hayakawa, Ming C. Hammond, Russell E. Vance

Publikováno v: Cell Reports, Vol 3, Iss 5, Pp 1355-1361 (2013)

The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS

Externí odkaz: https://doaj.org/article/2a539847a7d542709f20c5ca08f20165

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

Autor: Yoshihiro Hayakawa, Mamoru Hyodo, Elie J. Diner, Stephen C. Wilson, Kathryn M. Monroe, Ming C. Hammond, Colleen A. Kellenberger, Russell E. Vance, Dara Burdette

Publikováno v: Cell reports, vol 3, iss 5
Cell Reports, Vol 3, Iss 5, Pp 1355-1361 (2013)
Diner, EJ; Burdette, DL; Wilson, SC; Monroe, KM; Kellenberger, CA; Hyodo, M; et al.(2013). The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING. Cell Reports, 3(5), 1355-1361. doi: 10.1016/j.celrep.2013.05.009. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/25w00962

The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e864eda99b763ee725603c9a96aa9640
https://doi.org/10.1016/j.celrep.2013.05.009

Identification of a target cell permissive factor required for contact-dependent growth inhibition (CDI)

Autor: Julia S. Webb, Elie J. Diner, Christopher S. Hayes, David A. Low, Christina M. Beck

Publikováno v: Genes & Development. 26:515-525

Bacterial contact-dependent growth inhibition (CDI) is mediated by the CdiB/CdiA family of two-partner secretion proteins. CdiA effector proteins are exported onto the surface of CDI+ inhibitor cells, where they interact with susceptible bacteria and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae8e06d95dc31053fd335427a4f66db
https://doi.org/10.1101/gad.182345.111

Recombineering Reveals a Diverse Collection of Ribosomal Proteins L4 and L22 that Confer Resistance to Macrolide Antibiotics

Autor: Elie J. Diner, Christopher S. Hayes

Publikováno v: Journal of Molecular Biology. 386:300-315

Mutations in ribosomal proteins L4 and L22 confer resistance to erythromycin and other macrolide antibiotics in a variety of bacteria. L4 and L22 have elongated loops whose tips converge in the peptide exit tunnel near the macrolide-binding site, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566cfa27f799bcc6110f1efdeea1f971
https://doi.org/10.1016/j.jmb.2008.12.064

The toxin/immunity network of Burkholderia pseudomallei contact-dependent growth inhibition (CDI) systems

Autor: Kiel, Nikolakakis, Saba, Amber, J Scott, Wilbur, Elie J, Diner, Stephanie K, Aoki, Stephen J, Poole, Apichai, Tuanyok, Paul S, Keim, Sharon, Peacock, Christopher S, Hayes, David A, Low

Publikováno v: Molecular microbiology. 84(3)

Burkholderia pseudomallei is a Category B pathogen and the causative agent of melioidosis – a serious infectious disease that is typically acquired directly from environmental reservoirs. Nearly all B. pseudomallei strains sequenced to date (>85 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4677e09d87c89c171a79352dda58035a
https://pubmed.ncbi.nlm.nih.gov/22435733