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pro vyhledávání: '"Elie Farhat"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described tissue-specific contributions of membrane lipid composition remodeling and mitochondrial function to metabolic suppression across different goldfish tissu
Externí odkaz:
https://doaj.org/article/ce21628329d6492cb5a9ca49223e062d
Autor:
Elie Farhat, Jean-Michel Weber
Publikováno v:
Metabolites, Vol 11, Iss 8, p 503 (2021)
Metabolic suppression is an essential strategy to cope with chronic hypoxia. This review examines the physiological processes used to survive in low oxygen environments. It proposes a novel mechanism–the remodeling of membrane lipids–to suppress
Externí odkaz:
https://doaj.org/article/9c39630bb2e14ed9bde073c78ef5d461
Publikováno v:
Metabolites, Vol 11, Iss 3, p 187 (2021)
Hypometabolism is a hallmark strategy of hypoxia tolerance. To identify potential mechanisms of metabolic suppression, we have used the goldfish to quantify the effects of chronically low oxygen (4 weeks; 10% air saturation) on mitochondrial respirat
Externí odkaz:
https://doaj.org/article/f472a1d9a4bd4d2f846ce10a8cbfae72
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Naked mole-rats (NMRs) are mammalian champions of hypoxia tolerance that enter metabolic suppression to survive in low oxygen environments. Common physiological mechanisms used by animals to suppress metabolic rate include downregulating energy metab
Autor:
Elisa Thoral, Elie Farhat, Damien Roussel, Hang Cheng, Ludovic Guillard, Matthew E. Pamenter, Jean-Michel Weber, Loïc Teulier
Publikováno v:
Journal of Experimental Biology. 225
Some hypoxia-tolerant species, such as goldfish, experience intermittent and severe hypoxia in their natural habitat, causing them to develop multiple physiological adaptations. However, in fish, the metabolic impact of regular hypoxic exposure on sw
Autor:
Jean-Michel Weber, Elie Farhat
Publikováno v:
Metabolites, Vol 11, Iss 503, p 503 (2021)
Metabolites
Metabolites
Metabolic suppression is an essential strategy to cope with chronic hypoxia. This review examines the physiological processes used to survive in low oxygen environments. It proposes a novel mechanism–the remodeling of membrane lipids–to suppress
Publikováno v:
Neuroscience letters. 764
Matching ATP supply and demand is key to neuronal hypoxia-tolerance and failure to achieve this balance leads to excitotoxic cell death in most adult mammalian brains. Ion pumping is the most energy-demanding process in the brain and some hypoxia-tol
Publikováno v:
Metabolites
Metabolites, MDPI, 2021, 11 (3), pp.187. ⟨10.3390/metabo11030187⟩
Metabolites, Vol 11, Iss 187, p 187 (2021)
Metabolites; Volume 11; Issue 3; Pages: 187
Metabolites, MDPI, 2021, 11 (3), pp.187. ⟨10.3390/metabo11030187⟩
Metabolites, Vol 11, Iss 187, p 187 (2021)
Metabolites; Volume 11; Issue 3; Pages: 187
Hypometabolism is a hallmark strategy of hypoxia tolerance. To identify potential mechanisms of metabolic suppression, we have used the goldfish to quantify the effects of chronically low oxygen (4 weeks; 10% air saturation) on mitochondrial respirat
Publikováno v:
Neuroscience Letters. 764:136244
Matching ATP supply and demand is key to neuronal hypoxia-tolerance and failure to achieve this balance leads to excitotoxic cell death in most adult mammalian brains. Ion pumping is the most energy-demanding process in the brain and some hypoxia-tol
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 237:110326
Hypoxia-tolerant animals use metabolic suppression as an essential strategy to survive low oxygen. Ectotherms can alter membrane lipid composition in response to changes in environmental temperature, but it is currently unknown whether chronic hypoxi