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pro vyhledávání: '"Elias Zavaro"'
c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth
Autor:
Jean M. Francis, Razie Amraei, Elias Zavaro, Nader Rahimi, Marc A Napoleon, Jonathan D. Ravid, Uma R. Phatak, Nkiruka Arinze, Vipul C. Chitalia, Wenqing Yin, Chimera Lyle, Joshua Walker, Irva Vellard, Ian R. Rifkin, Sean Richards, Mostafa Belghasem, Kei Yasuda
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect of c-Cbl on the tumor microenvironment remains poorly understood. Here we demonstrate th