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of 6
pro vyhledávání: '"Elias W Krumholz"'
Autor:
Hong Yang, Elias W Krumholz, Evan D Brutinel, Nagendra P Palani, Michael J Sadowsky, Andrew M Odlyzko, Jeffrey A Gralnick, Igor G L Libourel
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003848 (2014)
Transposon mutagenesis, in combination with parallel sequencing, is becoming a powerful tool for en-masse mutant analysis. A probability generating function was used to explain observed miniHimar transposon insertion patterns, and gene essentiality c
Externí odkaz:
https://doaj.org/article/07abc409acf04af58d95ec660176f4de
Sequence-based Network Completion Reveals the Integrality of Missing Reactions in Metabolic Networks
Autor:
Igor G. L. Libourel, Elias W. Krumholz
Publikováno v:
Journal of Biological Chemistry. 290:19197-19207
Genome-scale metabolic models are central in connecting genotypes to metabolic phenotypes. However, even for well studied organisms, such as Escherichia coli, draft networks do not contain a complete biochemical network. Missing reactions are referre
Autor:
Igor G. L. Libourel, Elias W. Krumholz
Publikováno v:
Biophysical journal. 113(3)
In pursuit of establishing a realistic metabolic phenotypic space, the reversibility of reactions is thermodynamically constrained in modern metabolic networks. The reversibility constraints follow from heuristic thermodynamic poise approximations th
Publikováno v:
Journal of experimental botany. 63(6)
The green picoalga Ostreococcus is emerging as a simple plant model organism, and two species, O. lucimarinus and O. tauri, have now been sequenced and annotated manually. To evaluate the completeness of the metabolic annotation of both species, meta
Autor:
Igor G. L. Libourel, Michael J. Sadowsky, Elias W. Krumholz, Evan D. Brutinel, Nagendra P. Palani, Andrew Odlyzko, Jeffrey A. Gralnick, Hong Yang
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 10, Iss 9, p e1003848 (2014)
PLoS Computational Biology, Vol 10, Iss 9, p e1003848 (2014)
Transposon mutagenesis, in combination with parallel sequencing, is becoming a powerful tool for en-masse mutant analysis. A probability generating function was used to explain observed miniHimar transposon insertion patterns, and gene essentiality c
Autor:
Chad L. Myers, Amy A. Caudy, Corey Nislow, Balázs Papp, Elias W. Krumholz, Colin Pesyna, Balázs Szappanos, David C. Hess, Tahin Syed, Benjamin VanderSluis, Olga G. Troyanskaya
Publikováno v:
Genome Biology
Background: Genome-wide sensitivity screens in yeast have been immensely popular following the construction of a collection of deletion mutants of non-essential genes. However, the auxotrophic markers in this collection preclude experiments on minima